Celederm

Various means are used to treat complicated dermatoses. Tselederm has proven itself as an effective and safe drug. Let's consider its main characteristics and properties.

Tselederm is a combination product for topical use. It contains antimicrobial and corticosteroid components.

• Betamethasone (topical glucocorticosteroid) has anti-inflammatory, vasoconstrictive and long-lasting antipruritic effects.
• Gentamicin is an antibiotic (aminoglycoside) with a pronounced bactericidal effect against many microorganisms.

Pharmacological group of the drug – corticosteroids in combination with antibiotics for use in dermatology.

Indications Celederm

Corticosteroids are prescribed to treat inflammatory and autoimmune diseases. Tselederm is used in dermatology, let's consider the main indications for its use:

• Treatment and prevention of dermatoses
• Dermatoses complicated by secondary infection
• Various forms of eczema
• Dermatitis (solar, contact, seborrheic, intertriginous, exfoliative)
• Neurodermatitis
• Psoriasis
• Senile and anogenital pruritus

During the use of the ointment, it is necessary to avoid immunization and vaccination. Celederm is contraindicated for long-term application to damaged skin areas. The ointment cannot be used with occlusive dressings or diapers. The drug should be discontinued gradually to prevent adverse reactions and dermatitis with burning and intense redness of the skin.

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Release form

Tselederm is prescribed for topical use. The drug is available in cream form. Tselederm is available in aluminum tubes of 15 g, each tube in a cardboard box.

1 g of cream contains the following substances: betamethasone 1 mg and gentamicin 1 mg. The following are additional: sodium phosphate dodecahydrate, anionic emulsified wax, cetostearyl alcohol, chlorocresol, sodium hydroxide, sodium dihydrogen phosphate, propylene glycol, mineral oil and other components.

Pharmacodynamics

The mechanism of action of the product is determined by the effectiveness of its components. The pharmacodynamics of Tselederm are represented by the following substances:

• Betamethasone – reduces the release of anti-inflammatory cytokines, stimulates the synthesis of endogenous substances with anti-edematous activity (lipocortins) and inhibits the metabolism of arachidonic acid. The component reduces the permeability of the vascular walls and has an anti-allergic effect.
• Gentamicin – has bactericidal activity against many gram-negative and gram-positive aerobic microorganisms. Does not affect anaerobic bacteria, fungi and viruses.

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Pharmacokinetics

After applying the drug to the skin, the active ingredients begin to be absorbed and have a systemic effect. The pharmacokinetics and absorption of gentamicin are higher than that of betamethasone. The ointment does not penetrate into the systemic bloodstream, so it does not affect the functioning of the body. Celederm is not recommended for application to damaged skin surfaces and use with occlusive dressings or compresses.

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Dosing and administration

Since the product is indicated for many skin diseases, the method of application and doses of Tselederm are selected for each patient individually. The cream is not recommended for application to areas with damaged skin integrity and mucous membranes. If it is applied to large areas of skin, this increases the risk of developing systemic side effects. The cream is not recommended for rubbing or using with occlusive dressings. It is not used in ophthalmology; if the product accidentally gets into the eyes, they must be thoroughly rinsed with running water.

If the dermatosis or any other skin disease is mild, the ointment is applied once a day. In more severe forms of skin lesions, the product is applied two or more times a day. If there is no improvement after two weeks of treatment, you should consult a doctor. Withdrawal should be gradual. Long-term use of the ointment can lead to irritation, growth of resistant microflora, sensitization or superinfection.

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Use Celederm during pregnancy

Treatment of dermatoses and any other skin lesions during pregnancy is a complex process. Since it is necessary to select the safest but most effective drug for the expectant mother. The use of Tselederm during pregnancy is contraindicated. If there is a need to use this medication during lactation, it is recommended to consult with your doctor and stop breastfeeding. The cream is not prescribed for the treatment of patients under two years of age.

Contraindications

The main contraindication to the use of external agents for the treatment of various skin diseases is hypersensitivity to its active components. Tselederm is contraindicated for use in case of individual intolerance to betamethasone, gentamicin and antibiotics of the aminoglycoside group.

• The drug is not prescribed to patients with tuberculosis of the skin, rosacea, varicose veins, chickenpox and herpes simplex.
• Skin manifestations of syphilis, diseases of fungal or bacterial etiology are also contraindications for the use of the ointment.
• The drug is not recommended for use in patients with various skin lesions, perioral dermatitis, burns, skin reactions after vaccination, and complex forms of plaque psoriasis.
• The medication is not recommended for pregnant and lactating women. It is used with special caution in pediatrics, since the absorption of corticosteroids in children is higher than in adults. The ointment is not prescribed to patients under two years of age.

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Side effects Celederm

Using the drug without a doctor's prescription can cause various adverse reactions. Side effects of Tselederm are manifested as:

• Systemic reactions – arterial hypertension, edema, weight change, ulcerative lesions of the gastrointestinal mucosa, menstrual irregularities, drowsiness, increased fatigue, insomnia, changes in blood plasma glucose levels. In children, growth retardation, increased intracranial pressure and the development of Cushing's syndrome are possible.
• Local reactions – irritation, dryness, itching, peeling of the skin. Rash, pigmentation disorder, folliculitis, hypertrichosis, contact and perioral dermatitis. If Tselederm is used with an occlusive dressing, skin atrophy, secondary infection, maceration, prickly heat, and stretch marks may occur.

The risk of developing adverse reactions increases significantly when applying the product to large areas of skin. If the ointment has caused the symptoms described above, you should seek medical help.

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Overdose

If the medicine is used over a long period of time or on a large surface area of the body, it can cause a number of adverse reactions. Overdose manifests itself as increased allergic reactions, skin itching, burning, redness. As a rule, all these symptoms are mild. Acute overdose with local application is not observed.

Chronic corticosteroid intoxication is possible with long-term therapy, which causes a disruption of the pituitary-adrenal function. This pathology is accompanied by the development of Cushing's disease, hypercorticism and secondary adrenal insufficiency. Long-term treatment provokes the growth of resistant microflora due to the action of gentamicin.

Symptomatic therapy is used to eliminate symptoms of overdose and chronic intoxication. The drug should be discontinued gradually to minimize the side effects of corticosteroids.

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Interactions with other drugs

Treatment of skin diseases is a complex and lengthy process, so for its effectiveness, several products are used simultaneously. Interaction with other drugs is possible with complex therapy, which is prescribed by a doctor. In this case, the cream cannot be applied to one affected area of the skin at the same time as other medications.

When used with antibiotic creams and ointments from the aminoglycoside group, allergic reactions are possible. Tselederm is contraindicated in the treatment of ophthalmological diseases. If no positive reactions are observed within 14 days after the start of therapy, the drug is discontinued and another regimen is prescribed.

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Storage conditions

The cream should be kept in its original packaging, protected from sunlight and out of reach of children. Storage conditions allow preserving the medicinal properties of the medicine throughout the entire shelf life. The storage temperature should not exceed 25 °C.

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Shelf life

Celederm is a corticosteroid drug used to treat inflammatory and infectious skin diseases. The shelf life of the cream is 24 months from the date of manufacture, which is indicated on the aluminum tube or cardboard packaging. After this period, the medicine must be disposed of.