Cefophyde

Cefobide has antibacterial effect.

Indications Cefobida

It is used to eliminate infectious lesions affecting the following areas:

• urethra ducts;
• respiratory system;
• joints with bones;
• epidermis and subcutaneous tissues;
• gonorrhea ;
• peritonitis with cholecystitis, as well as other lesions of the abdominal zone;
• septicemia or meningitis;
• salpingitis or endometritis;
• as prevention of complications after surgical procedures of orthopedic, gynecological or abdominal nature.

[1], [2], [3], [4]

Release form

The release is realized in a lyophilizate for injection liquid, in flakonchikah capacity of 1 g.

[5], [6], [7]

Pharmacodynamics

Cefoperazone is a semi-artificial antibiotic from the category of cephalosporins. Enter it is allowed exclusively parenteral method. The bactericidal effect develops after the inhibition of binding within the cell membranes of microbial pathogens.

Demonstrates activity against most clinically important bacteria. Affects the action of streptococci with staphylococci, Klebsiella with Salmonella, Escherichia and Clostridia, and in addition to this proteus, meningococci, shigella, gonococci, β-hemolytic streptococci and so on.

[8], [9]

Pharmacokinetics

After the injection of the drug, it is found in large concentrations inside the bile with blood and urine. Therapeutic values are recorded inside all tissues with liquids, atria, sputum, cord blood, and also the sinuses of the appendages, palatine tonsils, prostate with kidneys and in women in pelvic organs. Peak indices inside bile are 100 times higher than serum values and are observed after 1-3 hours.

Excretion occurs with bile, but also urine. The half-life is 2 hours and does not change depending on the methods of administration. Together with urine after 12 hours, 20-30% of drugs are excreted (with healthy renal activity). With a second injection in a healthy person, the cumulation of the substance does not develop.

Disturbance in the work of the liver prolongs the half-life of the drug from the blood, as well as excretion along with the urine. If kidney / liver failure is noted, cumulation within the blood develops.

[10], [11]

Dosing and administration

Intramuscular injections are carried in the thigh or muscle buttocks.

The adult daily portion is 2-4 g, administered at intervals of 12 hours. When treating severe stages of infection, the portion is increased to 8 g / day. For children it is required to prescribe 50-200 mg / kg per day. Enter this portion should be divided into 2-3 equal applications.

The therapy continues until the indications regarding the sensitivity of the bacteria are obtained.

In the case of urethritis, which has gonococcal nature, once injected 0.5 g intramuscularly.

With IV injection, a single dose is 2000 mg, which is administered for 3-5 minutes. If an injection is administered through a dropper, the procedure should last 20-60 minutes.

To prevent complications after surgical procedures, intravenous administration should be started 1 hour before the operation, and then repeated at intervals of 12 hours for the first day. This period can be extended to 72 hours if procedures with a high probability of infection, open heart surgery or joint prosthesis are performed.

Dosage portions can be changed in case of serious illnesses, but it is necessary to take into account that a maximum of 2000 mg is allowed per day.

With intramuscular injections, the drug is diluted in 2% lidocaine solution and injection liquid. First, a liquid is used to dissolve the lyophilizate, and then lidocaine is added to the mixture.

[17]

Use Cefobida during pregnancy

Tests on the effect of drugs on the work of reproductive organs were performed on rabbits, as well as monkeys and rats. At the same time, the dosages were 10 times higher for humans. Weakened fertility and teratogenic effects were not found. However, there were no controlled appropriate tests involving pregnant women. Therefore, in this period, it is recommended to prescribe Cefobide only if there are life indications in the patient.

Small amounts of the drug element pass into the mother's milk, because of which the drug should be carefully administered to nursing mothers.

Contraindications

Contraindicated to use in the presence of symptoms of allergy or high sensitivity to cephalosporins with penicillins.

[12], [13]

Side effects Cefobida

The use of medication can trigger the emergence of adverse symptoms:

• rashes that have a maculopapular shape, drug fever, pruritus and urticaria;
• a decrease in the values of hemoglobin or neutrophils, and in addition the development of eosinophilia, bleeding, hypoprothrombinemia or curable neutropenia;
• moderate increase in ALT, APF or ACT;
• pseudomembranous form of colitis, vomiting, and also loose stool, which stops after the end of therapy;
• Intravenous injections can cause phlebitis, and intramuscular injections can cause pain.

[14], [15], [16]

Overdose

Because of intoxication, potentiation of negative manifestations is noted. High values of drugs inside the CSF can cause seizures and development of neurological signs.

To eliminate violations appoint sedatives, as well as diazepam (with convulsions). The active element is removed from the circulatory system by hemodialysis.

[18], [19], [20], [21]

Interactions with other drugs

When drinking alcohol, even after the end of Cefobed therapy, disulfiramoid-like symptoms developed (headaches, hyperhidrosis, tachycardia and hot flashes). Because of this drink alcohol is prohibited for another 5 days from the completion of therapy.

Cefoperazone and aminiklikozidy have no compatibility, so their solutions are forbidden to mix. If complex treatment is required, sequential infusions are carried out by the drip method, in which separate catheters are used. Enter Cefobide before aminoglycosides.

There may be a false-positive response to the glucose values inside the urine when a solution of Felling or Benedict is administered.

[22], [23], [24],

Storage conditions

The cepobide must be kept at temperatures not exceeding 30 ° C.

[25]

Shelf life

Cefobide is allowed to be used within 24 months of the release of the therapeutic drug.

Application for children

Cefoperazone is allowed to be administered to babies from birth.

Since large-scale tests regarding the effect of drugs on newborns and premature babies have not been performed, the use and risk of such treatment should be carefully assessed before the medication is prescribed.

[26], [27], [28], [29]

Analogues

The analogues of the medication are Cefoperus, Medotsef and Tsefpar, and in addition, Dardum, Cefoperabol, Movoperiz and Cephoperazone.

[30], [31], [32]

Reviews

Cefobed, being a third-generation cephalosporin, has a wide range of bactericidal effects, which is why it is effective in treating many pathologies. Its feature is the ability of the active element to excrete both in urine and in bile. It is because of this that it demonstrates efficacy in the treatment of infections affecting the VLT and peritoneal organs, as well as inflammation in the kidneys. But at the same time, this particular excretion has a negative effect on the intestinal biocenosis.

In this regard, the use of drugs containing cefoperazone, often causes severe negative manifestations in the form of diarrhea. Complications of bowel function are noted with a frequency of about 6-10%. Many patients complain about this deficiency of the drug in their reviews.