Cefixim

Cefixime has antibacterial properties.

[1], [2], [3], [4], [5], [6]

Indications Cefix

It is used for therapy in diseases that are of an infectious and inflammatory nature: bronchitis with tonsillitis, and also sinusitis, pharyngitis and otitis media. In addition, it is used for infections that affect the urogenital system, and have an uncomplicated form, as well as with gonorrhea without complications.

[7], [8]

Release form

The release of the substance is realized in a suspension, in flakonchikah volume of 26 g. Inside the box - 1 such a bottle, equipped with a measuring device.

Also produced in a tablet form, 10 pieces each having a volume of 0.2 or 0.4 g, inside the blister pack. In pack 1 such a package.

[9], [10]

Pharmacodynamics

The drug is an antibiotic from the category of cephalosporins of the 3rd generation and has a wide range of activity. You need to consume medicines orally. The drug depresses the binding in the region of the cell membranes of the bacterium pathogen. Has resistance to the influence of β-lactamases, which are produced by a large number of gram-positive and-negative microbes.

Demonstrates activity relative to:

• Gram-positive microorganisms - streptococcus agalactia, pneumococci and pyogenic streptococci;
• Gram-negative microbes - salmonella, providences, vulgar proteium, shigella, pasteurella multicida, marcecens serrice, Klebsiella pneumonia, and also oxytoca. Also on the list are Citrobacter amalonaticus, proteus mirabilis, E. Coli, Citrobacter diversus, moraxella catarrhis, hemophilic rod, gonococcus and Haemophilus parainfluenzae.

Resistance to drugs are shown by clostridia, enterobacteria, pseudomonas, staphylococci, bacteriguids frugilis, streptococcus subgroup D, and also listeria monocytogenes.

[11], [12], [13], [14], [15]

Pharmacokinetics

After ingestion, the level of bioavailability of the substance is 50% regardless of the intake of food. But while the peak values inside the blood, the active element is faster when consumed with food (for 50 minutes). Plasma synthesis with protein is approximately 65%.

About 50% of the portion is excreted unchanged with urine in 24 hours; with bile, about 10% of the substance is excreted. The half-life is approximately 4 hours (the exact figure depends on the portion size).

[16], [17], [18], [19], [20]

Dosing and administration

Mode of use of tablets.

The use of pills is required for persons who have reached the age of 12 years. The daily dosage is 0.4 g, which is taken once per day or divided into two equal doses. The duration of the treatment cycle is within 7-10 days. For therapy with gonorrhea, taking place without complications, one-time intake of 0.4 g of drugs is required.

Children under 12 years of age are prescribed medicine in portions that are calculated in a ratio of 8 mg / kg (once per day) or 4 mg / kg (at intervals of 12 hours).

To treat infections that were caused by the activity of pyogenic streptococcus, a 10-day therapeutic cycle is required.

Scheme of application of the suspension.

To dissolve the powder for the suspension, use simple boiled water (volume approximately 30-35 ml). It is required to open the bottle and pour water into it to half, then close and shake the container. Then the bottle is opened again and water is added to the indicated level. After that, the container is closed again and shaken. Shake is necessary before each intake. Use the medication before or after eating.

Persons from the age group of 0.5-12 years should take 4 mg / kg of medication (use at intervals of 12 hours) or 8 mg / kg (once per day). The duration of therapy is chosen in accordance with the clinical situation to each person individually. Often such a cycle lasts 3-14 days.

The measuring device is necessary for obtaining dosages prescribed for children weighing less than 25 kg (0.1 g / 5 ml).

Patients from special groups.

If there are problems with renal function (CC level within 20-60 ml / minute) or in people who undergo hemodialysis sessions, the size of the daily portion should be reduced by a quarter.

With QC values below 20 ml / minute or in people undergoing peritoneal dialysis procedures, the daily dose is reduced by half.

[25], [26], [27]

Use Cefix during pregnancy

Prescribe Cefixime during pregnancy is allowed exclusively under the supervision of a doctor for life indications.

Use of the medication while breast-feeding is completely prohibited.

Contraindications

It is contraindicated to use the medicine in the presence of intolerance with regard to medicinal elements or penicillins with cephalosporins.

[21], [22]

Side effects Cefix

Taking medication can provoke the appearance of various negative manifestations:

• disorders of digestive activity: bloating, nausea, anorexia, abdominal pain, dry mouth mucosa, vomiting and diarrhea. In addition, there is a transient increase in the transaminase level of the liver or AF, hyperbilirubinemia, jaundice, dysbacteriosis with glossitis and stomatitis, as well as candidiasis in the digestive organs and pseudomembranous form of enterocolitis;
• disorders of hematopoiesis: leuko-, thrombocyto- or neutropenia, as well as hemolytic form of anemia;
• problems with the work of the National Assembly: the occurrence of headaches or dizziness;
• disorders of the urogenital character: tubulointerstitial nephritis;
• allergy symptoms: itching, febrile condition, eosinophilia, urticaria and cutaneous hyperemia.

[23], [24]

Overdose

Among the signs of poisoning: potentiation of negative symptoms.

To eliminate the disorders requires the procedure of gastric lavage, symptomatic measures, oxygen therapy (this includes the use of GCS and antihistamines), as well as IVL. The drug has no antidote and it is not practically excreted in peritoneal dialysis or hemodialysis.

[28], [29], [30], [31]

Interactions with other drugs

Drugs that slow the secretion of the tubules inhibit the excretion of the drug through the kidneys, which is why its toxic properties are intensified.

Cefixim reduces the values of PTI, and also activates the medicinal effect of indirect anticoagulants.

Magnesium or aluminum-containing antacids slow the absorption of the therapeutic drug.

[32], [33], [34], [35], [36], [37]

Storage conditions

Cefixime should be kept in a dark place inaccessible to children. The temperature level is not higher than 25 ° C.

The finished suspension can be contained at the above temperature for not more than 10 days. Do not freeze or cool the medicine.

[38]

Shelf life

Cefixime is allowed to be used within 24 months of the release of the therapeutic drug.

Application for children

It is forbidden to prescribe medication to infants less than 6 months of age.

[39], [40], [41], [42], [43],

Analogues

The analogues of the medication are Cefoperazone, Ceftazidime with Cefotaxime, and in addition Ceftibutene with Ceftriaxone.

[44], [45], [46], [47]

Reviews

Cefixim receives good enough reviews from the people treated with it. They note the high drug efficiency, low cost and the presence of dosage forms that can be given to children. Also a plus is the rarity of the development of signs of allergy or dysbiosis.