Cefecon

Cefepon has analgesic, anti-inflammatory and antipyretic properties.

Indications Cefecona

Cefepon N is used as an analgesic for pains of varying intensity, developing against such violations:

• tooth pain, and in addition neuralgia and sciatica with lumbago;
• headaches and migraine attacks;
• pathologies that are degenerative-dystrophic in nature, and affect the function of ODA (such as osteochondrosis, Bechterew's disease or osteoarthritis);
• myalgia;
• algodismenorea, which has a primary character.

As an antipyretic is prescribed for the treatment of fever arising from diseases that have inflammatory, infectious or catarrhal etiology.

Cefexon D is used for children:

• as an antipyretic in ARVI with influenza, complications after vaccination, childhood infections and other conditions, against which there is an increase in temperature;
• as an analgesic for pain of different genesis (myalgia with neuralgia, painful sensations arising from burns or injuries, as well as dental or headaches).

Release form

The release is made in the form of rectal suppositories, 5 pieces inside a blister pack. The box contains 2 such blisters.

Pharmacodynamics

Cefekon N is a complex remedy from the category of drugs that have analgesic and antipyretic effects. The substances naproxen with salicylamide have an anti-inflammatory effect and are non-steroidal. Caffeine stabilizes and potentiates the excitatory processes in the cerebral cortex.

The drug helps exchange processes inside various organs with tissues (for example, in the muscle, as well as the central nervous system).

The child's analogue of the drug (Cefekon D) stimulates the blockade of the COX element inside the central nervous system, which affects the thermoregulatory system and pain centers. Inside the inflamed area, the effect of paracetamol on COX is neutralized by cellular peroxidase, and therefore its anti-inflammatory effect is significantly weakened.

The medication does not have a negative effect on the gastrointestinal mucosa and water-salt balance, so that sodium and water do not stay inside the body.

[1], [2], [3], [4]

Pharmacokinetics

Cefekon D is absorbed intensively through the intestinal mucosa. Its peak values within the blood are recorded 10-60 minutes after the administration of the suppository.

The drug easily passes through the BBB. It has pronounced bioavailability, and its distribution occurs mainly within liquids. Protein synthesis is rather weak - less than 10%. Metabolism of the substance occurs inside the liver.

Excretion is carried out through the kidneys - inactive substances decay products are derived (glucuronides with sulfates).

Dosing and administration

Use suppositories Cefecon H is allowed only after intestinal defecation or carrying out a cleansing enema.

For the day 1-3 times the first suppository is administered. After the introduction of the drug into the rectum, the patient needs to lie about 40 minutes in bed.

If the suppository is used as an analgesic, the course should last for a maximum of 5 days, and if used as an antipyretic, a maximum of 3 days.

Application of Cefekon D.

Suppositories should be administered rectally. It is necessary to carry out the procedure after performing a cleansing enema. Introduction of drugs is carried out 2-3 times a day. A single dose of drugs on average should be up to 15 mg / kg, and the maximum allowable dosage for a day is 60 mg.

Infants aged 1-3 months are required to administer 1 suppository once a day (contains 0.05 g of paracetamol). Dimensions of other dosages:

• a child within the age of 3-12 months (with a weight of 6-10 kg) is administered 1-2 suppositories with a volume of 0.1 g;
• for the age of 1-3 years (weight 10-15 kg) - 1-2 suppositories with a volume of 0.1 g;
• age group 3-10 years (weight indices - 16-32 kg) - introduction of the first suppository with a volume of 0.25 g;
• a child aged 10-12 years (weight values - 33-36 kg) requires the introduction of 2 suppositories with a volume of 0.25 g.

It is forbidden to apply the medication for a long time. To reduce the heat, it is used no more than 3 days, and to eliminate pain - a maximum of 5 days.

 

[6]

Use Cefecona during pregnancy

Cefekon D is allowed to be given to pregnant or lactating women only after assessing the risk and benefits of the medication. The tests did not reveal embryotoxic, mutagenic or teratogenic effects in paracetamol.

Cefekon N is not allowed for lactation or pregnancy.

Contraindications

Among the contraindications:

• tendency to develop bleeding;
• glaucoma, having a closed-angle shape;
• people in old age;
• gastric or intestinal ulcer;
• insufficiency of liver or kidney function;
• the presence of intolerance against the drug;
• increased blood pressure;
• strong excitability or insomnia;
• diseases affecting the function of SSS;
• bronchial obstruction;
• HOF.

Cefekon D is not prescribed if there is a strong sensitivity to paracetamol or alcoholism of a chronic nature.

It is used with caution in diseases affecting the blood system, the enzymatic absence of the element G6PD (hereditary nature) and the problems with the work of the liver or kidneys in an expressed degree.

Side effects Cefecona

The use of Cefekon H can lead to the appearance of the following negative symptoms:

• gastritis with stomatitis (sometimes ulcerative form), heartburn, melena and vomiting (sometimes bloody) with constipation, as well as esophagitis. In addition, there are ulcers, bleeding or perforations in the gastrointestinal tract, pancreatitis, bloating and exacerbation of ulcerative colitis or transmural ileitis;
• development of neutropenic or leukopenia, agranulocytosis, eosinophilia or hemolytic form of anemia;
• bronchial spasms, allergy manifestations, anaphylaxis and Quincke edema;
• hyperglycemia or -coliemia;
• feelings of confusion, sleep disorder, hallucinations, depression or insomnia;
• vasculitis;
• a feeling of anxiety or anxiety, tremors, cramps and cognitive impairment, and in addition dizziness or headaches. Potentiation of reflexes, problems with concentration of attention, aseptic form of meningitis, paresthesia and neuritis affecting the optic nerve are also noted;
• visual disorders, opacity of the eye cornea, papillitis and swelling in the visual disk;
• auditory disorders;
• insufficiency of cardiac activity, swelling, arrhythmia and a feeling of pressure in the chest;
• pulmonary edema, dyspnoea, nasal congestion and pneumonia of eosinophilic nature;
• jaundice or hepatitis, as well as an increase in the number of hepatic enzymes;
• rashes, erythema multiforme, pustular manifestations, itching, Stephen-Johnson syndrome, photophobia, alopecia, lichen planus and SLE. In addition, there is purpura, bruises, urticaria, erythema nodosum, TEN and hyperhidrosis;
• pain or weakness in the muscles;
• increased urination, hematuria, necrotic papillitis, nephrotic syndrome, and in addition glomerulonephritis, kidney failure, tubulointerstitial nephritis and increased creatinine values;
• infertility in women;
• feeling of thirst or malaise, severe fatigue and febrile state.

A child's analogue can cause such manifestations:

• vomiting with nausea;
• leuko- or thrombocytopenia, agranulocytosis, as well as anemia;
• signs of allergies (rashes or itching in the epidermis and mucous membranes, as well as urticaria);
• hemolytic form of anemia, necrotic papillitis or tubulointerstitial nephritis.

[5]

Overdose

Poisoning with Cefekton N can provoke or intensify the severity of negative manifestations: tachycardia, dizziness, bronchial spasms, heart failure, itching and pain inside the rectum, and increase blood pressure. In addition, hyperthermia, arrhythmia, tremor, diarrhea and ear ringing can develop. Along with this, there is sometimes a feeling of anxiety, irritability, agitation, confusion, disorientation or drowsiness. There are also seizures, bleeding inside the gastrointestinal tract, headaches and dehydration, the urination process becomes more frequent, hypersensitivity of the tactile character and delirium develops.

If such symptoms appear, you must abolish the use of drugs and perform symptomatic measures that support the work of the heart and lower blood pressure.

There may also appear uncomfortable sensations or itching inside the rectum - in these cases, an enema with sunflower oil is recommended.

Interactions with other drugs

Combinations with Cefekon N.

When combined with the drug, a decrease in the antihypertensive effect of ACE inhibitors and β-adrenoblockers is noted.

Combination with sulfonylurea derivatives (among them anticoagulants or antidiabetic medications for ingestion) leads to potentiation of their medicinal properties.

Combination with Cefekton D.

Combination with salicylates significantly increases the likelihood of a nephrotoxic effect.

Use together with paracetamol potentiates the toxic properties of chloramphenicol, weakens the drug efficacy of drugs that slow down binding and accelerate the excretion of uric acid, and also enhances the effect of indirect anticoagulants.

[7], [8]

Storage conditions

Cefekon should be kept at temperatures not exceeding 25 ° C.

Shelf life

Cefekon N is allowed to be used within 24 months from the date of manufacture of drugs. The pediatric form of the medicine has a shelf life of 36 months.

Application for children

Cefekon N is not prescribed for persons under the age of 16. Children's uniform is not used in infants until the 1st month.

Analogues

Analogues of Cefekon N are Asafen and Acelizin preparations, and in addition Asperer with Copacil and Citramon.

Analogues of the pediatric form of the drug are children's Panadol, Tylenol and Paracetamol, and besides this, Bindard and Volpan, Dafalgan, Danafrade Junior and Dainafed EX. Also in the list Paracetamol MS, Deminofen, Efferalgan and Kalpol 6 plus.

Reviews

Cefekon N receives many good reviews from patients - it is reported that it is effective in relieving pain and reducing fever. Already after 30 minutes, there is a significant improvement in the condition, the pain disappears, and the fever is weakened. In addition to high drug effectiveness, the drug has a low cost, which is why it is used very often.

They also note the high therapeutic effectiveness of Cefekon D. Suppositories. This medicine is especially popular, because it can be used in children who are often categorically unwilling to use syrups or tablets of analgesics or antipyretics, or in cases when the syrup in children causes the development of vomiting. Therefore, it is the suppositories with antipyretic effects that are considered to be the best option.