Cefecon

Cefekon has analgesic, anti-inflammatory and antipyretic properties.

Indications Cefecon

Cefekon N is used as a pain reliever for pain sensations of varying intensity that develop against the background of the following disorders:

• toothache, and in addition neuralgia and sciatica with lumbago;
• headaches and migraine attacks;
• pathologies of a degenerative-dystrophic nature and affecting the function of the musculoskeletal system (such as osteochondrosis, Bechterew's disease or osteoarthritis);
• myalgia;
• algomenorrhea of a primary nature.

As an antipyretic, it is prescribed for the treatment of fever that occurs in diseases of inflammatory, infectious or catarrhal etiology.

Cefekon D is used for children:

• as an antipyretic for acute respiratory viral infections with influenza, complications after vaccination, childhood infections and other conditions that cause an increase in temperature;
• as an analgesic for pain of various origins (myalgia with neuralgia, pain caused by burns or injuries, as well as toothaches or headaches).

Release form

The product is produced in the form of rectal suppositories, 5 pieces inside a blister pack. The box contains 2 such blisters.

Pharmacodynamics

Cefekon N is a complex drug from the category of drugs that have an analgesic and antipyretic effect. The substances naproxen with salicylamide have an anti-inflammatory effect and are non-steroidal. Caffeine stabilizes and potentiates the excitatory processes carried out inside the cerebral cortex.

The medicine helps metabolic processes within various organs and tissues (for example, in muscles, as well as the central nervous system).

The children's analogue of the drug (Tsefekon D) stimulates the blockade of the COX element inside the central nervous system, thereby affecting the thermoregulatory system and pain centers. Inside the inflamed area, the effect of paracetamol on COX is neutralized by cellular peroxidase, due to which its anti-inflammatory effect is significantly weakened.

The medication does not have a negative effect on the gastrointestinal mucosa and water-salt balance, due to which sodium and water are not retained in the body.

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Pharmacokinetics

Cefekon D is intensively absorbed through the intestinal mucosa. Its peak values in the blood are recorded 10-60 minutes after the suppository is administered.

The drug easily passes through the BBB. It has pronounced bioavailability indicators, and its distribution occurs mainly within liquids. Protein synthesis is quite weak - less than 10%. The substance is metabolized within the liver.

Excretion occurs through the kidneys – inactive breakdown products of the substance (glucuronides with sulfates) are excreted.

Dosing and administration

The use of Cefekon N suppositories is permitted only after bowel movement or a cleansing enema.

1 suppository of the drug is administered 1-3 times a day. After the drug is administered into the rectum, the patient should lie in bed for about 40 minutes.

If suppositories are used as an analgesic, the course should last a maximum of 5 days, and if they are used as an antipyretic, a maximum of 3 days.

Use of Cefekon D.

Suppositories should be administered rectally. The procedure should be performed after a cleansing enema. The drug is administered 2-3 times a day. A single dose of the drug should average up to 15 mg/kg, and the maximum permissible daily dosage is 60 mg.

Infants aged 1-3 months require 1 suppository (contains 0.05 g paracetamol) once a day. Other dosage sizes:

• for a child aged 3-12 months (weighing 6-10 kg), 1-2 suppositories of 0.1 g are administered;
• for children aged 1-3 years (weight 10-15 kg) – 1-2 suppositories of 0.1 g;
• age group 3-10 years (weight indicators – 16-32 kg) – introduction of 1 suppository with a volume of 0.25 g;
• A child aged 10-12 years (weight 33-36 kg) requires the administration of 2 suppositories with a volume of 0.25 g.

The medication is prohibited to be used for a long time. To reduce high temperature, it is used for no more than 3 days, and to eliminate pain - a maximum of 5 days.

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Use Cefecon during pregnancy

Cefekon D may be prescribed to pregnant or breastfeeding women only after assessing the risks and benefits of the medication. Tests have not revealed any embryotoxic, mutagenic or teratogenic effects in paracetamol.

Cefekon N is prohibited during lactation or pregnancy.

Contraindications

Among the contraindications:

• tendency to develop bleeding;
• closed-angle glaucoma;
• elderly people;
• stomach or intestinal ulcer;
• liver or kidney failure;
• the presence of intolerance to the medication;
• elevated blood pressure;
• severe excitability or insomnia;
• diseases affecting the function of the cardiovascular system;
• bronchial obstruction;
• CHF.

Cefekon D is not prescribed in the presence of severe sensitivity to paracetamol or chronic alcoholism.

It should be used with caution in diseases affecting the blood system, enzymatic absence of the G6PD element (hereditary) and problems with the liver or kidneys to a significant degree.

Side effects Cefecon

The use of Cefekon N may result in the following adverse symptoms:

• gastritis with stomatitis (sometimes ulcerative form), heartburn, melena and vomiting (sometimes bloody) with constipation, as well as esophagitis. In addition, ulcers, bleeding or perforations in the gastrointestinal tract, pancreatitis, bloating and exacerbation of ulcerative colitis or transmural ileitis are noted;
• development of neutro- or leukopenia, agranulocytosis, eosinophilia or hemolytic anemia;
• bronchospasms, allergic reactions, anaphylaxis and Quincke's edema;
• hyperglycemia or -kalemia;
• feeling confused, sleep disturbances, hallucinations, depression or insomnia;
• vasculitis;
• a feeling of anxiety or restlessness, tremors, convulsions and cognitive impairment, as well as dizziness or headaches. Also noted is potentiation of reflexes, problems with concentration, aseptic meningitis, paresthesia and neuritis affecting the optic nerve;
• visual disturbances, corneal opacity, papillitis and swelling in the area of the optic disc;
• hearing impairment;
• cardiac insufficiency, swelling, arrhythmia and a feeling of pressure in the chest;
• pulmonary edema, dyspnea, nasal congestion and eosinophilic pneumonia;
• jaundice or hepatitis, as well as increased liver enzymes;
• rashes, erythema multiforme, pustular manifestations, pruritus, Stevens-Johnson syndrome, photophobia, alopecia, lichen planus and SLE. In addition, purpura, ecchymosis, urticaria, erythema nodosum, TEN and hyperhidrosis occur;
• pain or weakness in the muscles;
• increased urination, hematuria, necrotizing papillitis, nephrotic syndrome, and in addition glomerulonephritis, renal failure, tubulointerstitial nephritis and increased creatinine levels;
• infertility in women;
• feeling thirsty or unwell, severe fatigue and fever.

The children's analogue can cause the following symptoms:

• vomiting with nausea;
• leukopenia or thrombocytopenia, agranulocytosis, and anemia;
• signs of allergy (rashes or itching in the epidermis and mucous membranes, as well as urticaria);
• hemolytic anemia, necrotic papillitis or tubulointerstitial nephritis.

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Overdose

Poisoning with Cefekon N can provoke or increase the severity of negative manifestations: tachycardia, dizziness, bronchial spasms, cardiac insufficiency, itching and pain inside the rectum, and increase the level of blood pressure. In addition, hyperthermia, arrhythmia, tremor, diarrhea and tinnitus can develop. Along with this, a feeling of anxiety, irritability, agitation, confusion, disorientation or drowsiness sometimes appears. Also, seizures, bleeding inside the gastrointestinal tract, headaches and dehydration appear, the process of urination becomes more frequent, tactile hypersensitivity and delirium develop.

If such symptoms appear, it is necessary to stop using the drug and perform symptomatic measures to support the work of the heart and reduce blood pressure.

There may also be discomfort or itching inside the rectum – in these cases, an enema with sunflower oil is recommended.

Interactions with other drugs

Combinations with Cefekon N.

When combined with the drug, a decrease in the antihypertensive effect of ACE inhibitors and β-blockers is noted.

Combination with sulfonylurea derivatives (including anticoagulants or antidiabetic drugs for oral administration) leads to potentiation of their medicinal properties.

Combination with Cefekon D.

Combination with salicylates significantly increases the likelihood of a nephrotoxic effect.

Use together with paracetamol potentiates the toxic properties of chloramphenicol, weakens the medicinal effectiveness of drugs that slow down the binding and accelerate the excretion of uric acid, and also enhances the effect of indirect anticoagulants.

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Storage conditions

Cefekon must be kept at temperatures not exceeding 25°C.

Shelf life

Cefekon N is allowed to be used within 24 months from the date of release of the drug. The children's form of the drug has a shelf life of 36 months.

Application for children

Cefekon N is not prescribed to persons under 16 years of age. The children's form is not used in infants under 1 month.

Analogues

Analogues of Cefekon N are the drugs Asafen and Acelizin, as well as Aspeter with Kopatsil and Citramon.

The children's analogues of the drug are children's Panadol, Tylenol and Paracetamol, as well as Bindard and Volpan powders, Dafalgan, Danafred Junior and Dynafed EX. Also on the list are Paracetamol MS, Deminofen, Efferalgan and Calpol 6 plus.

Reviews

Cefekon N receives many good reviews from patients - it is reported to be effective in relieving pain and reducing high temperature. After 30 minutes, a significant improvement in the condition is noted, the pain disappears, and the fever is reduced. In addition to high medicinal effectiveness, the drug has a low cost, which is why it is used very often.

The high therapeutic effectiveness of Cefekon D suppositories is also noted. This medicine is especially popular because it can be used in children who often categorically do not want to take syrups or tablets of analgesics or antipyretics, or in cases where syrup causes vomiting in children. Therefore, suppositories with antipyretic action are considered the best option.