Cardioarginine

Cardioarginine is a metabolic drug with endothelium and cardioprotective effects, as well as adaptogenic and hypotensive effects.

The drug helps to reduce myocardial ischemia, improves coronary blood flow, stabilizes the endothelium of peripheral and coronary vessels, and also demonstrates membrane stabilizing, antiradical, antihypoxic and antioxidant activity. [1]

In the case of increased blood pressure values, the drug helps to stabilize the pressure and weakens the systemic resistance exerted by the peripheral vessels. [2]

Indications Cardioarginine

It is used for the combined treatment of CHF and IHD (a stable type of angina pectoris associated with vascular spasm or dysfunction, as well as pain-free myocardial ischemia), as well as atherosclerosis in the brain and cardiac vessels, hypercholesterolemia , diabetic angiopathy and low blood pressure.

In addition, it is prescribed at an early stage of the recovery period after a previous myocardial infarction and other somatic pathologies.

It can be used in the case of heart rhythm disorders associated with a lack of Mg and K inside the body (mainly in the case of ventricular arrhythmias), as well as when using SG and with obliterating endarteritis.

Release form

The drug is released in the form of an injection liquid - inside ampoules with a capacity of 5 ml. The pack contains 5 or 10 such ampoules.

Pharmacodynamics

The antihypertensive effect of drugs develops with the participation of arginine, which, being a donor of nitrous oxide, can potentiate endothelium-dependent vasodilation, and in addition, it regulates blood pressure and maintains the osmolarity of fluids inside the body and blood volume, joining the binding of arginine vasopressin (peptidergic hormone).

The cardioprotective metabolic effect of the drug is due to the fact that arginine, succinate and asparaginate are able to activate the energy supply of the heart muscle, restore the potential of cellular energy and stabilize intermediate metabolism with acid-base indicators; in addition, these substances stabilize protein metabolism within the myocardium and stimulate the binding of amino saccharin to amino acids and nucleotides. [3]

Asparaginate is an intracellular transporter of K + and Mg2 + ions. Its activity allows you to eliminate salt imbalance and improve coronary blood flow. Ions of the Mg2 + element help to activate the activity of Na + -K + -ATPase, which lowers the level of Na + ions inside cells and increases the severity of the passage of K + ions into them. A decrease in the intracellular values of Na + ions leads to a slowdown in the metabolism of these elements with the formation of Ca2 + ions inside the smooth vascular muscles, due to which it relaxes. K + ions help activate the binding of glycogen to acetylcholine, ATP and proteins.

Cardioarginine has adaptogenic-actoprotective activity, inducing cellular metabolism through substrates. Succinate with arginine and aspartate stimulates the enzymatic processes of the TCA and the cellular destruction of glucose with fatty acids during physical exertion. In addition, they have a positive effect on aerobic cellular energy supply and weaken lactic acidosis.

The effects described above help to increase the rate of adaptation during hypoxia, reduce severe fatigue and increase work capacity.

Dosing and administration

The medication is injected by the intravenous method - jet or through a dropper.

When using a dropper, intravenous administration of 5 ml of the substance, which is diluted in 5% glucose or 0.9% NaCl (0.1-0.2 l), is performed 1-2 times per day. The rate of administration is 20-30 drops / minute.

The drug is injected by the jet method in a dosage of 5 ml at a low speed (maximum 5 ml per minute) 1-2 times a day.

The therapy lasts within 5-10 days. It is allowed to inject no more than 10 ml of the drug per day.

After the end of the IV injection cycle, the patient, if necessary, can be transferred to the use of Cardioarginin in the form of a syrup for oral administration.

• Application for children

There is no information regarding the therapeutic efficacy and safety of the use of drugs in pediatrics.

Use Cardioarginine during pregnancy

There is no information regarding the drug safety of the drug during pregnancy, therefore it is not used during the specified period.

Do not breastfeed while using the medication.

Contraindications

The main contraindications:

• pronounced personal sensitivity to the elements of the medication;
• hyperkalemia;
• Stage 1-2 AV block.

Side effects Cardioarginine

Among the side effects:

• problems with digestive function: occasionally there is nausea, stomach pain and slight discomfort inside the gastrointestinal tract, diarrhea, vomiting, bloating, bleeding and ulcers inside the gastrointestinal tract, dyspeptic symptoms and thirst immediately after taking drugs, passing by themselves;
• disturbances in the work of the CVS: disturbance of conduction inside the heart ventricles and a decrease in blood pressure;
• disorders of the activity of the National Assembly: fever, dizziness, convulsions, muscle weakness, disorientation and facial hyperemia, and in addition, hyporeflexia, paresthesia, hyperhidrosis and respiratory depression;
• epidermal lesions: signs of allergy reaction (itching) may appear;
• others: asthenia, dyspnea, venous thrombosis, myasthenia gravis and phlebitis.

In the case of a high speed of intravenous injection, muscle hypotonia, arrhythmias, hyperkalemia or -magnesaemia, paresthesia in the extremities, inhibition of AV conduction and cardiac arrest may occur.

Overdose

In case of poisoning, stomach pain, paresthesia, hyperkalemia or -magnesaemia, metal taste and muscle stiffness appear, and blood pressure also decreases. In addition, the ECG shows an increase in the amplitude of the T-wave and a decrease in the amplitude of the P-wave, as well as an increase in the size of the QRS complex.

Symptomatic measures are taken to support the work of organs important for life, as well as parenteral Ca substances are administered.

Interactions with other drugs

It must be borne in mind that in the case of a combination of arginine and aminophylline, an increase in the blood insulin level is noted; when using the substance together with spironolactone, the blood potassium index increases.

The drug increases the tolerance of SG, and also potentiates the activity of drugs that stimulate myocardial trophism.

Cardioarginine prevents the occurrence of hypokalemia associated with the introduction of SG, saluretics and corticosteroids.

Combination with an ACE inhibitor or potassium-sparing diuretic substances increases the likelihood of hyperkalemia (you need to monitor the plasma potassium values).

The drug weakens the body's sensitivity to SG.

Storage conditions

Cardioarginin needs to be stored in a place that is closed from the penetration of small children. Do not freeze solution ampoules. Temperature level - maximum 25 ° C.

Shelf life

Cardioarginin can be used within 3 years from the date of manufacture of the pharmaceutical component.

Analogs

The analogs of the drug are the substances Cardiolin, Thiodarone and Advocaard with A-dystone, Korargin and Distonin with Alvisan, and in addition Cardiophyte and Validazol. In addition, the list includes Kratal with Zelenina drops, Khomviokorin and Validol with Cor compositum, Tricardin and Corvalment.