Cardiket

Cardiket acts on the body by relaxing the smooth muscles in the area of the vascular walls, which leads to the expansion of peripheral arteries with veins - it causes the development of a vasodilating effect.

As a result, there is a decrease in the values of diastolic pressure, and in addition, a reduction in the processes of reverse flow of venous blood into the heart ventricle, and at the same time a decrease in the volume of its filling. [1]

Indications Cardiket

It is used in the treatment and prevention of anginal attacks, ischemic heart disease , as well as myocardial infarction .

In addition, it can be prescribed in the case of CHF - in combination with other medicinal substances.

Release form

The drug is released in the form of tablets with a prolonged type of activity - 10 pieces in cell packs, 1 or 5 of these packs inside a pack.

Pharmacodynamics

Cardiket demonstrates antianginal activity. Contains isosorbide dinitrate (the substance is an organic nitrate). The drug has a vasodilating effect on veins with arteries. Together with this, there is a deposit of blood vessels inside the peripheral system, which leads to a decrease in venous cardiac return, a decrease in the final level of diastolic blood pressure, and in addition to a decrease in the volume of left ventricular filling. [2]

After oral administration, the medication dissolves inside the stomach after a few minutes. The active ingredient is released from the tablet for a long time. The development of the therapeutic effect occurs quickly, with the preservation of the effect over a long time period. [3]

Pharmacokinetics

The development of the drug effect is noted after 15 minutes from the moment the tablet was used. Bioavailability values are 22%, and protein binding rates are 30%.

The main metabolic elements that form inside the liver are isosorbide-2-mononitrate with isosorbite-5-mononitrate, which is excreted by the kidneys. Complete excretion occurs within 24 hours.

Dosing and administration

The attending doctor should be involved in the selection of the treatment regimen and portion sizes. The tablet is swallowed whole, without chewing, and washed down with plain water.

The use of 60-80 mg of the medication is usually prescribed per day (the portion should be divided into 1-3 injections). In the case of a 20 mg portion, the medicine should be taken in 1 tablet 2 times a day. Therapy is usually started with a small dosage and gradually increased. It is forbidden to abruptly cancel the drug intake.

• Application for children

It is forbidden to use Cardiket in pediatrics.

Use Cardiket during pregnancy

The medicine is used in breastfeeding and pregnancy only in situations where it is believed that the expected benefit is more likely than the risks of negative consequences for the fetus / child.

Contraindications

Among the contraindications:

• drug allergy;
• shock or vascular collapse;
• stenosis;
• marked decrease in blood pressure;
• diseases and conditions in which there is an increase in the level of ICP or IOP (glaucoma);
• hemorrhagic stroke and active phase of myocardial infarction;
• head injuries;
• a decrease in the volume of circulating blood;
• complex administration with substances that slow down the action of PDE-5 (among them are sildenafil with tadalafil and vardenafil).

Caution in use and medical supervision are necessary for such disorders:

• cardiac tamponade;
• severe anemia;
• pulmonary edema of a toxic nature;
• obstructive type of cardiomyopathy (hypertrophic in nature);
• constrictive pericarditis;
• low blood pressure values that are chronic;
• thyrotoxicosis;
• severe stages of hepatic or renal pathologies.

Side effects Cardiket

The main side signs:

• decrease in blood pressure, bradycardia, weakness, headaches and angina pectoris;
• drowsiness, slowing reactions and ischemia;
• belching, stomach pain, dry mouth and nausea;
• redness of the skin on the face, epidermal rash of allergic origin and tolerance to other nitrate substances.

Overdose

With intoxication, collapse, respiration, reddening of the epidermis, loss of consciousness, nausea, anoxia, diarrhea and coma are noted.

It is necessary to apply intravenously 1% methylene blue - in a dose of 2 mg / kg.

Interactions with other drugs

It is necessary to very carefully combine Kardiket with tricyclics, antipsychotics, antihypertensive substances, agents blocking the influence of Ca channels, vasodilators, adrenergic blockers, and in addition with novocainamide, alcohol, tadalafil and quinidine, vardenafil, sildenafil and dihydramine.

When combined with α-blockers or sympathomimetics, the antianginal effect is weakened.

A direct effect on the therapeutic efficacy of drugs is exerted by agents that have an enveloping effect on the stomach, since they reduce the rate of passage of the active component from the stomach into the circulatory system.

Atropine, together with other m-anticholinergics, is able to potentiate the likelihood of an increase in IOP.

The drug is allowed to be used together with amiodarone, nifedipine, propranolol, as well as riboxin and panangin.

Storage conditions

The cardicet must be kept out of the reach of children and sunlight.

Shelf life

Cardiket can be used for a 5-year period from the date of manufacture of the medicinal product.

Analogs

Analogues of drugs are drugs Nitrogranulong, Nitrosorbide and Isoket with Dikor Long, Monosan and Izodinite with Nitro-mic, Erinit and Mononitrosid with Isomik, as well as Nitro and Nitromint. In addition, the list includes Nitrokontin and Nitrosprey with Olikard retard, Nitroglycerin with Efoks long and Monokontin od.

Reviews

Cardiket receives mostly good reviews - it is often used for disorders of cardiac function or its pathologies.

Of the minuses, the presence of side symptoms is noted - usually headaches (sometimes of a very pronounced character). But at the same time, the medication allows you to stabilize the function of the heart muscle, regardless of the personal negative reactions of the patient's body.