Capicor

Kapikor is a complex medicine with cardiac effect.

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Indications Capicoras

It is used for combined treatment in such cases:

• IHD (eg, ischemic cardiomyopathy, angina pectoris, post-myocardial cardiosclerosis and myocardial infarction);
• SWF;
• cardiomyopathy of climacteric nature;
• disorders of circulatory processes inside the brain in acute or chronic stage ( cerebral stroke, cerebrovascular insufficiency and dyscirculatory form of encephalopathy);
• ICD;
• violation of vegetative activity.

Release form

The release of the substance is realized in capsules, in an amount of 10 pieces inside the blister pack. The box contains 2 or 6 such packages.

Pharmacodynamics

Kapikor is a combined medicine, medicamental activity of which is provided by a combination of two active elements: mordonium dihydrate and γ-butyrobetaine dihydrate.

This combination contributes to the development of rapid and strong cerebro- and cardioprotective effects, which ensures the independence of the rate of development of drug exposure from the degree of depletion of the organism under ischemia or stressful conditions of various origins (this includes oxidative genesis).

The γ-butyrobetaine dihydrate potentiates the activity of the drug, influencing the stimulation of NO biosynthesis processes, and also prevents the development of a toxic effect on free radicals against cells. Along with this, this element stabilizes the process of oxidative homeostasis inside cells and positively influences the activity of the endothelium.

Melodonium dihydrate slows down the movement of long chain fatty acids, as well as their metabolic products, into the mitochondria (by reducing the biosynthesis of carnitine), so that the aerobic metabolic pathway persists even with tissue hypoxia.

The drug prevents the depletion of cellular stocks of creatine phosphate and ATP, and in addition to cumulation of lactic acid, the development of acidosis inside cells, the disruption of enzyme processes and the disruption of the ion channels. In addition, the drug in a certain way affects the increase in the indices of γ-butyrobetaine dihydrate inside the body.

All these combined mechanisms help to establish optimal parameters of γ-butyrobetaine dihydrate, so that NO-dependent reactions become more pronounced and quick (among them antiplatelet, antioxidant, vasodilating, anticoagulant and other effects). Also, the drug helps to regulate the processes of proliferation and apoptosis, and at the same time it supports the vascular homeostasis and so on.

The drug has immunomodulating, cardio- and cerebroprotective, as well as anti-ischemic effects.

In case of insufficient cardiac function, the drug improves myocardial contractility and increases exercise tolerance. In people with a stable form of angina pectoris of the 2nd and 3rd functional type, Kapikor reduces the number of heart attacks, promotes the development of moderate antihypertensive effects, and also stabilizes heart rate.

In case of defeat of cerebrospinal vessels, the medication improves the functioning of cerebral hemodynamics, stabilizes metabolic processes inside nerve cells, and at the same time optimizes the amount of oxygen consumed by the brain tissues, which allows to achieve improvement in physical, mental and cognitive activity, to stabilize the psychoemotional background and reduce the feeling of overwork.

Pharmacokinetics

The drug used at high speed is absorbed from the digestive tract. Bioavailability indicators reach 78%. Peak plasma values are recorded after 1-2 hours after application.

In the process of metabolism, two main metabolic products are formed, which are excreted through the kidneys. The half-life of the drug element is about 3-6 hours.

Dosing and administration

You can use Kapikor without being tied to eating. When combined treatment - 2 capsules LS 1-3 times a day. The entire treatment course lasts 2-6 weeks. For a day allowed to consume no more than 6 capsules.

Carrying out repeated treatment cycles is allowed after consultation with the doctor (often within a year is allowed no more than 2-3 such courses).

Since the medication can have a stimulating effect, the latter should be taken at least 3-4 hours before bedtime.

Use Capicoras during pregnancy

There is no information on whether it is safe to use Capicor during pregnancy. To avoid possible negative effects on the fetus, it is recommended to abandon its use in this period.

Also, there is no evidence of whether the drug is excreted with human milk. If you need to use drugs during lactation, you should stop breastfeeding for the period of therapy.

Contraindications

The main contraindications:

• presence of strong sensitivity in relation to the medicament and its constituent elements;
• an increase in ICP rates (with the development of neoplasms within the skull or a disorder of venous outflow);
• problems with the work of the kidneys or liver in a severe degree;
• insufficiency of hepatic or renal activity.

Side effects Capicoras

The use of a drug can provoke the development of various side effects:

• Immune disorders: often allergy symptoms develop. Occasionally, there are manifestations of intolerance, among which hives, anaphylaxis, allergic form of dermatitis and edema Quincke;
• mental disorders: occasionally there is a feeling of excitement or fear, there are disorders of sleep and obsessive thoughts;
• lesions affecting the work of the National Assembly: headaches often develop. Occasionally there is tremor, ear noise, dizziness, paresthesia with vertigo and hypoesthesia, and in addition, a pre-fainting condition with a subsequent fainting and a gait disorder;
• problems with cardiac activity: heart rhythm rhythm changes occasionally, tachycardia (sometimes sinus), ciliary arrhythmia, palpitation, and pain and discomfort in the sternum;
• disorders of blood processes: occasionally the pallor of the skin, hyperemia, increase / decrease in blood pressure values and hypertensive crisis are noted;
• disruption of the respiratory organs, mediastinum and sternum: often there is a development of infections in the respiratory ducts. Occasionally there is a cough, inflammation inside the throat, apnea or dyspnea;
• symptoms that affect the functioning of the digestive tract: often there is indigestion. Occasionally, nausea, dysgeusia, swelling, pain in the abdominal region, vomiting, loss of appetite, diarrhea, hypersalivation or dryness of the oral mucosa;
• damage to the subcutaneous layers and epidermis: occasionally there are rashes, itching, as well as a systemic rash of maculopapular nature;
• disorders in the work of the musculoskeletal structure: occasionally there is weakness or spasms in the muscles, as well as pain in the back;
• disturbances of the urinary and renal functions: occasionally there is a pollakiuria;
• systemic lesions: occasionally there is chills, swelling in the legs or face, a feeling of general weakness, cold sweat, asthenia and a feeling of cold or heat;
• laboratory test data: often there is dyslipidemia or an increase in C-reactive protein. Occasionally there is eosinophilia, acceleration of the heart rhythm or deviation of the values on the ECG.

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Overdose

The drug has a low level of toxicity, so it does not cause life-threatening adverse reactions. There is also no information on cases of poisoning by milling.

Among the signs of overdose: increased heart rate, decrease in blood pressure (develops in the form of dizziness and headaches), as well as CNS excitation.

Symptomatic procedures are performed to eliminate these symptoms. With severe intoxication, it is necessary to monitor the functioning of the liver and kidneys.

Since in meldonia high levels of synthesis with blood protein, hemodialysis during an overdose of this substance can not have a significant result.

Interactions with other drugs

Kapikor is allowed to combine with nitrates that have a prolonged type of influence, and in addition to other antianginal drugs (stable form of angina pectoris), SG and diuretics (insufficiency of cardiac function). In addition, it can be used together with antiplatelet agents, anticoagulants, as well as antiarrhythmic drugs and other drugs that improve the microcirculation process.

Medication is able to potentiate the effectiveness of drugs that contain nifedipine or glyceryl trinitrate, and in addition, β-adrenoblockers, peripheral-type vasodilators and other antihypertensive drugs.

When combining meldoniya with iron drugs in people with iron deficiency anemia, there was an improvement in the structure of the acids inside the erythrocytes.

The combination of mellonium with vitamin B13 for the treatment of injuries caused by reperfusion or ischemia leads to the development of additional therapeutic effects.

Meldonium contributes to the elimination of pathological changes in the cardiac function developing under the influence of the AZT component, and also indirectly affects oxidative stress processes due to the same AZT, which results in the dysfunction of metophrenia. Combination meldonia and azidothymidine or other drugs for AIDS therapy leads to the development of a positive effect in the treatment of this disease.

During the testing of the loss of the equilibrium reflex due to the use of ethyl alcohol, meldonia shortened the duration of sleep.

With convulsions provoked by pentylenetetrazole, a powerful anticonvulsant effect of meldonia develops. At the same time, when using yoghimbine α2-adrenergic receptors in a dose of 2 mg / kg before treatment, as well as an agent that slows down the synthase of NO (COA) of N- (G) -nitro-L-arginine in a dose of 10 mg / kg, anticonvulsive effect of meldonia is completely blocked.

Mistonium intoxication can potentiate the cardiotoxic properties that develop with cyclophosphamide.

The lack of carnitine, formed when using meldonia, can lead to an increase in the cardiotoxic effect provoked by ifosfamide.

In the case of cardiotoxic effect, which occurs when indinavir is used, as well as the neurotoxic effect provoked by the activity of efavirenz, meldonia contributes to the development of protective effects.

It is forbidden to combine the medicine with other means, in which there is meldonia, because this potentiates the likelihood of developing negative symptoms.

[3], [4]

Storage conditions

Kapikor must be kept in a dark and dry place, closed from penetration of children. Temperature values - no more than 25 ° С.

Shelf life

Kapikor can be used within 36 months from the date of release of the drug.

Application for children

It is forbidden to prescribe a medication in pediatrics.

Analogues

The analogues of the medication are Ranex, Riboxin and Preductal, and in addition Durallan, Validol with glucose, Mildronate, Hawthorn tincture and Karmetadin with Magneter.