Candide

Candid has a local antifungal and antibacterial effect, and also has a trichomonacidal and antiprotozoal effect.

Indications Candida

It is used to treat the following symptoms or diseases:

• lichen, which has a multi-colored or pityriasis-like form;
• mycoses that occur in skin folds or on the feet;
• erythrasma;
• superficial candidiasis caused by the activity of mold, yeast and other fungi, dermatophytes and other pathogenic microbes that are sensitive to clotrimazole;
• mycoses complicated by the development of secondary pyoderma;
• candidal form of vulvitis or balanitis;
• epidermal candidiasis;
• paronychia of candidal nature;
• candidiasis in the area of the external genitalia or anus;
• diaper dermatitis of fungal origin.

The oral solution is used in the treatment of stomatitis of candidal etiology.

Vaginal tablets are prescribed for the treatment of infections and superinfections in the genital area caused by the activity of bacteria sensitive to clotrimazole.

In addition, Candid can be used as a sanitation in the birth canal area in preparation for childbirth.

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Release form

The drug is available in the form of a 2% gel, 1% cream for external use (in a 20 g tube), 1% powder for external use (in a 30 g plastic bottle), 1% solution for local use (in a 15 g bottle), and in addition in vaginal suppositories.

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Pharmacodynamics

The antifungal effect of clotrimazole (the active ingredient of the drug, which is an imidazole derivative) develops by destroying the processes of binding ergosterol, which is contained in the cell walls of the fungus. As a result, the degree of permeability of the fungal walls changes, which entails cell lysis.

There is an interaction of fungicidal indicators of the drug with mitochondrial and peroxidase enzymes, which provokes an increase in hydrogen peroxide values to a toxic level. This causes the destruction of fungal cells.

The drug has a fungicidal and fungistatic effect on dermatomycetes (red trichophyton, interdigital trichophyton, flocculent epidermophyton and downy microsporum), yeast-like and mold fungi (from the genus Candida, Candida glabrata, Pityrosporum orbiculare and the genus Rhodotorula).

In addition, clotrimazole has activity against the bacterium that causes lichen versicolor.

Candid effectively affects gram-negative and -positive microbes. In high concentrations, the drug demonstrates activity against vaginal trichomonas.

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Pharmacokinetics

The drug is poorly absorbed through the epidermis and mucous membranes, which is why there is no systemic effect when the drug is used locally. After external use, a higher concentration of the drug component is observed inside the epidermis than inside the dermis and subcutaneous layers.

After intravaginal administration, the absorption of the drug is 3-10% of the administered dosage. For 2-3 days, low levels of the drug are observed in the blood; the level of the drug in the vaginal secretion is quite high.

The exchange processes of clotrimazole take place inside the liver.

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Dosing and administration

Method of using the cream.

The cream should be applied externally, after washing and drying the affected areas of the epidermis. The skin should be cleaned with soap that has a neutral pH. The medicine should be applied in a thin layer, after which it is gently rubbed into the epidermis; this procedure should be carried out 2-3 times per day. The duration of the treatment cycle is determined by the doctor; the duration of this period depends on the severity of the pathology and the localization of the lesion, and along with this on the therapeutic effectiveness of the drug.

For the treatment of dermatomycosis, a minimum of a 1-month course is required, and with the versicolor form of lichen, the cream must be used within 1-3 weeks. Patients with fungal infections affecting the epidermis on the feet must constantly use the cream for at least 14 days after the disappearance of signs of the disease.

The use of the medication depends on the characteristic features of the course of the pathology and its intensity. Usually, the cream is rubbed into the affected area 2-3 times a day. It is also recommended to use it for 3-4 weeks additionally to completely eliminate the possibility of relapse.

Method of using the medicinal solution.

The solution is usually used for extensive lesions of the epidermis, and also for diseases developing in the scalp. When prescribing drops, you must strictly follow the instructions and recommendations of the doctor.

In case of treatment of lesions inside the oral cavity, it is necessary to wet a cotton swab in the solution (10-20 drops of the substance) and treat the affected areas with it; it is recommended to perform this procedure 3-4 times a day, doing the treatment as thoroughly as possible. The medicine is used until the clinical signs of the disease completely disappear.

Powder usage diagram.

The powder should be applied externally to the affected areas of the epidermis, 3-4 times a day. It is important that the treatment is regular - the treatment procedure should be carried out constantly.

The duration of the therapeutic cycle is determined by the severity of the pathology and the location of the lesion. For a complete cure of the disease, it is sometimes necessary to continue therapy even after the elimination of pronounced manifestations.

The therapy usually lasts for 1 month. People with pityriasis versicolor should use the medicine for 1-3 weeks, and people with erythrasma need to continue therapy for 0.5-1 month.

Use of vaginal suppositories.

The tablets must be administered intravaginally. The procedure is performed from a lying position, with the legs also bent. The suppositories should be used once a day, administered in the evening, before going to bed.

For sanitation before childbirth, it is necessary to administer 1 tablet of the medicine (0.5 g of therapeutic substance).

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Use Candida during pregnancy

There is no clinically reliable information regarding the fact that local use of Candida during pregnancy, as well as breastfeeding, negatively affects the body of a woman, fetus or infant. But the advisability of using the drug in the 2nd and 3rd trimesters, as well as during breastfeeding, should be determined exclusively by a doctor.

It is prohibited to treat the mammary glands with the medicine during breastfeeding.

Contraindications

Main contraindications:

• the presence of intolerance to clotrimazole or other components of the drug;
• use during menstruation.

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Side effects Candida

The use of the medication may cause the occurrence of certain side effects:

• itching, hives and a tingling or burning sensation in the area where the cream is applied;
• swelling, irritation and peeling of the epidermis, as well as blisters and erythema.

If the above symptoms occur, stop using the ointment.

After intravaginal administration of the drug, local irritation occasionally occurs, often disappearing on its own without stopping therapy. In addition, with this method of using Candida, the following negative symptoms may occur:

• burning sensation and itching;
• vaginal discharge or swelling of the vaginal mucosa;
• headaches;
• increased frequency of urination and development of intercurrent cystitis;
• the appearance of pain during sexual intercourse;
• burning sensation in the genital area in men.

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Overdose

Using the cream in large portions does not cause negative symptoms or the development of life-threatening conditions.

When taking the medicine orally, vomiting, signs of allergy, nausea, anorexia, gastralgia or pollakiuria may occur. Occasionally, a feeling of drowsiness or hallucinations may occur.

The drug has no antidote. When taken orally, the patient must be given activated charcoal and symptomatic measures must be taken.

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Interactions with other drugs

The effect of clotrimazole is weakened when combined with natamycin, nystatin, and amphotericin B. Therefore, Candid is not recommended for use in combination with the above medications.

There is no data on the development of negative effects of other drugs when the drug is combined with them. This is due to the fact that clotrimazole has weak resorption properties.

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Storage conditions

Candida must be kept in a place closed to small children. Temperature values are within the range of 2-25°C.

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Shelf life

Candid in cream form can be used within 4 years from the date of release of the drug. The therapeutic solution has a shelf life of 36 months.

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Application for children

The solution is used to treat stomatitis in children. It must be used strictly according to the instructions and as prescribed by a doctor. In addition, it is prescribed to treat some fungal diseases in young children - for example, thrush (only a doctor can prescribe the drug in these cases).

Newborns with candidiasis can also be prescribed a solution of the drug. The therapy procedure is performed after feeding the baby. It is necessary to moisten a cotton swab or stick in the solution (3-4 drops), and then carefully treat the diseased areas inside the oral cavity with it. Such a procedure should be carried out 3 times a day. After 2-3 days, noticeable signs of improvement in the condition should appear.

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Analogues

The analogs of the drug are Imidil, Antifungol, Candibene, Imidil cream, as well as Amiklon with Clotrimazole, Candizol with Canesten and Candid-B6.

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Reviews

Candid receives mostly positive comments from patients. Many of them note the high effectiveness of the cream in treating disorders caused by pathologies of fungal origin.

The solution is often used for therapy in children, because the drops are more convenient to use, and also almost from the first procedure they weaken the negative signs of diseases.

Reviews from adults also contain information that the use of gel or cream allowed them to completely cure fungal diseases and eliminate all negative symptoms. This allows us to conclude that Candid in all therapeutic forms has high medicinal effectiveness.