Candibens

Kandibene is a medicine with antibacterial, antimycotic and fungicidal properties.

Indications Candibens

The cream is used to treat such disorders:

• mycoses;
• candidiasis in the nail and epidermis;
• mycoses on the folds of skin;
• deprive of an otrigious character;
• eritrism in the footsteps;
• accompanying mycosis pyoderma.

Use of vaginal tablets:

• superinfections that occur in the genital area;
• trichomoniasis ;
• vulvovaginal candidiasis;
• procedure of sanitation in pregnant women before childbirth.

Release form

The drug is released in vaginal tablets with a volume of 0.1 and 0.2 grams, and in addition in the form of an external treatment cream (30 g tube) and 1% solution for external treatment (40 ml bottle).

[1]

Pharmacodynamics

Clotrimazole is an antifungal agent, an imidazole compound. Its therapeutic effect is based on the destruction of the processes of ergosterol binding inside the cell walls of the fungus. This leads to a change in the permeability of such a wall, provoking the lysis of the fungal cell. Along with this, clotrimazole provokes an increase in the hydrogen peroxide indices inside fungal cells to toxic values. The component has a large range of medicamentous effects.

At low concentrations, the drug has fungistatic properties, and in case of increasing the dose, it acquires a fungicidal effect.

It has an effect on yeast-like fungi, dermatophytes, microbes that provoke the development of a pityrious form of lichen, as well as erythrasms. It also has antimicrobial properties - sensitivity to the drug is demonstrated by streptococci, trichomonads and staphylococci with a gardnerella vaginalis.

Pharmacokinetics

The active element of the cream when absorbed locally is poorly absorbed, because of which the drug does not have a systemic effect. The indices inside the deep cutaneous layers significantly exceed the values of LS within the subcutaneous tissues.

After intravaginal administration of the tablet, only 3-10% of the dosage is absorbed. High rates of medication within the vaginal secretion continue to persist for the next 50-70 hours.

Exchange processes of the drug substance take place inside the liver.

Dosing and administration

Diagram of the use of the cream.

Treatment with cream is made exclusively externally; Apply it should be 2-3 times a day, on the previously cleaned and dried areas of the epidermis, while slightly rubbing it.

The duration of the therapeutic cycle is determined by the location of the lesion, as well as by the severity of the disease. With dermatomycosis, the course lasts 1 month, with pityriasis, within 1-3 weeks. With skin fungi on the legs, it is necessary to continue therapy for another 14 days after the elimination of the manifestations of the disease.

Do not use cream near the eyes. Also, you can not continue therapy if irritation occurs. People with liver failure need to monitor the liver during treatment.

When treating onychomycosis, it is recommended to use the solution, because it has higher penetrating properties.

Mode of use of tablets.

Tablets are used exclusively intravaginally - they need to be administered in the evening, before going to bed, staying in a horizontal position on the back, and using a special applicator.

The medicine is allowed to be used during pregnancy, and during this period it is allowed to inject it without using an applicator.

To enter tablets it is necessary daily, during 6 days (at use of tablets in volume of 0,1 g). Also, a 3-day course can be conducted (in this case, tablets having a volume of 0.2 g are used). On the appointment of a doctor, a second course can be conducted.

For sanation in the field of the birth canal, a 1-fold tablet is required.

When menstruation therapy is not carried out, because menstrual flow weaken the effectiveness of the drug.

Together with therapy, a woman is treated and treated by her partner - to avoid reinfection after recovery.

[3]

Use Candibens during pregnancy

Kandibene in the form of a cream is forbidden to use on the 1st trimester of pregnancy.

Contraindications

Contraindicated use in people with intolerance to the elements of the drug.

Side effects Candibens

The use of the cream can cause such side effects: itching and burning sensation, tingling in the treatment zone, swelling, erythema, as well as blisters, ecdysis and irritation of the epidermis, and development of urticaria.

The introduction of tablets can provoke itching and burning sensation inside the vagina.

[2]

Overdose

After the local use of drugs in excessively high portions, the overdose does not develop. Unintentional oral medication can cause anorexia, vomiting, allergy symptoms, a feeling of drowsiness, nausea and stomach pain.

To eliminate the disturbances, the patient should take sorbents. Kandibene does not have an antidote.

Interactions with other drugs

Natamycin, nystatin, and amphotericin B weaken the drug effect of clotrimazole.

Storage conditions

Kandibene should be kept at a temperature of 25 ° C maximum.

[4]

Shelf life

Kandibene in the form of a cream can be used within 4 years of the release of the therapeutic drug. The shelf life of vaginal tablets is 5 years.

Application for children

It is forbidden to use the medicine in pediatrics (for persons who have not reached the age of 18).

Analogues

Analogues of the drug are medicines Amicon, Kandizol, Kanison and Klotrisal with Kanesten, and in addition Funginal, Clotrimazole-Acry, Imidil and Candide.

Reviews

Kandibene gets quite conflicting reviews - some he helps to cure thrush, but there are also such women for whom the drug was useless.

Excellent results in the therapy of mycosis in the region of the feet (there are no nail lesions at the same time), and besides, with diarrhea of fungal origin in children, the cream demonstrates.