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Candesar
Last reviewed: 23.04.2024
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Release form
The release is made in tablets, in an amount of 10 pieces inside the blister pack. In the box - 1 such blister.
Pharmacokinetics
Absorption and distribution processes.
After using the drug, the candesartan cilexetil component is converted to the active element candesartan. The indicator of its bioavailability with the oral solution of cilexetil candesartan is approximately 40%. The level of relative bioavailability of the tablet form of LS in comparison with the solution is approximately 34%, and its variability is extremely low. The level of calculated bioavailability of the drug in the form of tablets is 14%.
Peak serum medication values are noted after 3-4 hours after ingestion. The values of candesartan within the serum increase linearly - with the increase in dosages in the therapeutic spectrum.
Candidartan pharmacokinetic parameters are not dependent on the sex of the patient.
The values of the AUC of the drug inside the serum after a joint application with food vary insignificantly.
There is a high binding of candesartan to plasma protein (above 99%). The distribution volume of the substance is 0.1 l / kg.
Values of Candesare's bioavailability do not change when taken with food.
Metabolic processes and excretion.
Excretion of unchanged candesartan occurs with bile and urine. Only a small part of the substance passes the metabolism inside the liver (component CYP2C9). Existing information, taken from the interaction tests, does not show that the medication affects the elements of CYP2C9, as well as CYPZA4. In vitro tests have shown that the drug does not interact in vivo with medicaments whose metabolic processes depend on the isoenzymes of the hemoprotein P450-CYP1A1 and CYP2A6, as well as CYP2C9 with CYP2C19 and CYP2D6, and in addition CYP2E and CYP3A4. The terminal half-life of the substance is approximately 9 hours. With multiple use of drugs, accumulation of the drug component is not noted.
The parameters of the total clearance of the drug are approximately 0.37 ml / minute / kg; renal - approximately 19 ml / minute / kg. The clearance of the substance inside the kidneys is carried out through the filtration of the glomeruli, as well as the active secretion of the tubules.
When a 14 C-labeled component of cilexetil candesartan is used, about 26% of the portion is excreted along with the urine under the guise of a candesartan element, and another 7% is disguised as an inactive metabolic product. Another 56% candesartan is excreted with feces (as an inactive decay product - 10%).
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Dosing and administration
Selection of the sizes of portions of Candesar is carried out for each patient individually. The recommended initial dosage is 4-8 g per day.
Use of the candesaar during pregnancy
It is not recommended to use antagonists of the endings of angiotensin-2 (such is the component of candesartan) in the 1st trimester. The drug is contraindicated for use in the 2nd and 3rd trimesters.
Because there is no information on the use of drugs during breastfeeding, it is not recommended to appoint it in this period. It is necessary to use alternative drugs, the safety of which, when taken by lactating women, is established more reliably (in particular, it concerns the feeding of premature and newborn babies).
Side effects of the candesaar
The use of the drug can trigger the occurrence of side effects: headaches, pain in the back, arthralgia, diarrhea, myalgia, dizziness, dyspeptic symptoms and loss of strength.
Interactions with other drugs
Clinical tests of drug interaction were conducted using drugs such as warfarin with glibenclamide, hydrochlorothiazide with nifedipine and digoxin, and oral contraception (such as ethinylestradiol with levonorgestrel) and enalapril. At the same time, there was no clinically significant therapeutic effect on the body.
Combined use with potassium-sparing diuretics, potassium-containing substitutes for edible salt, and, in addition, potassium supplements or other drugs (such as heparin) can lead to an increase in potassium. With such combinations of drugs, you need to closely monitor potassium levels.
When combined with an ACE inhibitor and lithium drugs, a reverse increase in serum lithium values and also its toxicity was observed. Such an effect can develop with the use of APA-II. Therefore, the combination of Candesar and lithium is prohibited. If such a combination is necessary, during the therapy you need to closely monitor the values of lithium inside the blood serum.
The use of the drug along with NSAIDs (such as selective inhibitors of the COX-2 element) and non-selective NSAIDs, as well as aspirin (in a dose> 3 g / day), its antihypertensive effect may be reduced.
As with the use of ACE inhibitors, the combination of the drug with NSAIDs may lead to an increased likelihood of weakening renal function (renal insufficiency in acute form may develop, and serum potassium may increase, especially in those with initially weak kidney function). This combination must be used very carefully, especially the elderly. Patients should consume enough fluid, and the kidneys should be monitored after the start of the complex therapy and periodically thereafter.
Storage conditions
Kandesar must be kept in a dry place away from children. Temperatures are not higher than 25 ° C.
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Shelf life
Candesar can be used for 2 years from the date of release of the drug.
Application for children
The effectiveness and safety of taking medication is not established in persons younger than 18 years of age. For this reason, you can not assign it to this category of patients.
Analogues
Analogues of the medicine are such medications as Atakand and Cantab with Advant, Casark, Kandekor and Khizart.
Reviews
Candesar receives a large number of positive reviews about his therapeutic effectiveness.
Attention!
To simplify the perception of information, this instruction for use of the drug "Candesar" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.