Calcium dobesylate

Calcium dobesilate is a capillary stabilizing drug. It belongs to the category of angioprotective agents.

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Indications Calcium dobesylate

It is used in the following cases:

• in cases of vascular lesions against the background of increased permeability and fragility of capillaries (diseases such as diabetic retinopathy, as well as various forms of microangiopathy);
• in other microangiopathies arising from pathological metabolic processes and diseases in the cardiovascular system (such as steroid vasculitis and hormone-related bronchial asthma);
• in case of venous insufficiency, as well as complications of this disease (this includes pre-varicose conditions with symptoms of tissue edema, paresthesia, pain), and in addition to this, in case of congestive dermatoses, superficial forms of phlebitis, trophic ulcers and varicose veins on the legs.

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Release form

The product is produced in tablets, 10 pieces inside a blister pack. In a separate pack - 5 blister plates. It can also be produced in jars - 50 pieces inside 1.

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Pharmacodynamics

The medicine has an antiplatelet effect and also protects veins and capillaries.

Reduces increased capillary and arteriole permeability, increases the elasticity of vessel walls and erythrocytes, and improves microcirculation processes, rheological parameters of blood and drainage properties of lymph vessels. At the same time, it reduces blood viscosity, slightly reduces platelet aggregation and potentiates the effect of platelets (also antioxidant).

The drug is able to reduce the activity of plasma kinins (such as bradykinin, etc.) and reduce tissue swelling, and in addition has antihemorrhagic properties.

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Pharmacokinetics

The drug is absorbed rather slowly inside the gastrointestinal tract. Only 20-25% is synthesized with protein inside the plasma. Peak values inside the body are noted after 5-6 hours. The drug almost does not pass through the BBB.

The half-life is 24 hours. Excretion occurs mainly through the kidneys within 24 hours.

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Dosing and administration

The drug is taken orally, with or after food. The dosage is 250 mg (the size of 1 tablet) taken three times a day, or 0.5 g (the size of 2 tablets) taken 1-2 times a day. This regimen lasts 2-3 weeks, after which the dose is reduced to 0.5 g per day. This regimen continues for at least 3-4 weeks and a maximum of several months (the duration depends on the effectiveness of the drug). If necessary, repeated courses are allowed.

During the treatment of diabetic retinopathy, as well as microangiopathy, it is necessary to drink 1 tablet 2-3 times a day for 4-6 months. The exact duration of treatment depends on the course of the pathology and the effectiveness of the therapy used.

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Use Calcium dobesylate during pregnancy

Calcium dobesilate is not prescribed to pregnant or breastfeeding mothers.

Contraindications

Main contraindications:

• intolerance to the drug;
• bleeding that was caused by the use of anticoagulants;
• aggravated ulcers in the duodenum or stomach;
• bleeding inside the gastrointestinal tract;
• liver or kidney pathologies;
• use for children.

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Side effects Calcium dobesylate

The drug is often very well tolerated. Occasionally, dyspepsia, headaches, allergic dermatitis, dizziness, vomiting, fever and nausea, as well as diarrhea and gastralgia, fever and increased liver transaminase activity may occur. If such symptoms develop, the dosage should be reduced or the drug should be discontinued.

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Interactions with other drugs

Calcium dobesilate potentiates the properties of heparin with indirect anticoagulants, as well as GCS. It also enhances the antidiabetic effect of sulfonylurea derivatives. It is prohibited to combine the drug with lithium drugs, as well as methotrexate.

When used in combination with ticlopidine, it enhances its antiplatelet properties.

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Storage conditions

Calcium dobesilate should be kept in a dry, dark place, out of the reach of small children.

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Special instructions

Reviews

Calcium dobesilate is recommended by neurosurgeons to eliminate specific migraine attacks because it can improve the function of blood vessels and blood circulation processes.

Reviews of the drug show that in addition to its high efficiency, the advantage of the drug is the rarity of side effects when using it.

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Shelf life

Calcium dobesilate is allowed to be used for 3 years from the date of manufacture of the drug.