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Calcium chloride
Last reviewed: 23.04.2024
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Indications of the calcium chloride
It is used for the following diseases:
- functional deficiency of parathyroid glands (such pathologies as tetany or spasmophilia);
- increased calcium excretion (also due to a prolonged period of time in a stationary state);
- allergic pathologies (urticaria with edema Quincke, pollinosis and serum sickness, this list includes diseases caused by taking medication);
- strengthening of the walls of blood vessels (weakened due to vasculitis of hemorrhagic nature or radiation sickness);
- with the development of exudative lesions or inflammations (such as pneumonia or salpingo-oophoritis, as well as pleurisy or endometritis);
- lesions of the skin surface (eczema or psoriasis);
- hepatic intoxication, eclampsia, as well as nephritis or hepatitis of the parenchymal type;
- myoplegia of paroxysmal type (hyperkaliemic form);
- endogenous or external bleeding;
The drug is used in the form of an antidote to eliminate intoxication with ethanedioic acid, as well as its salts, magnesium salts and soluble salts of hydrofluoric acid. They use it and as a stimulant of labor.
Release form
The release is carried out in the form of a solution in ampoules with a volume of 5 ml. Inside the package there are 10 such ampoules.
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Pharmacodynamics
The medicine helps to fill the lack of the substance Ca2 +, without the participation of which the normal transmission of impulses by means of nerve endings is impossible. In addition, the deficiency of the substance prevents normal muscle contraction (skeletal, as well as smooth), disrupts the myocardium, as well as the processes of blood circulation and formation of bone tissue.
Calcium chloride helps to prevent the development of an inflammatory response to the pathogen, strengthen vascular cells and walls, and in addition to strengthen the body's immune response to infection. Along with this, the drug significantly enhances the process of phagocytosis (for example, when it decreases due to the use of sodium chloride).
Injection of the drug in / in a way stimulates the activity of the sympathetic department of the VNS, and besides it has a moderate diuretic effect and increases the amount of adrenaline secreted by the adrenals.
Pharmacokinetics
About 20-30% of the oral solution is absorbed through the small intestine. The rate of absorption depends on the pH of the stomach, dietary characteristics, as well as the presence of calciferol and certain factors that can synthesize Ca2 +.
The increase in absorption occurs if there is a lack of the body element Ca inside, and in addition, when applying a diet that includes a reduced intake of Ca2 +.
Inside the plasma, about half of the applied dosage (about 45%) is synthesized with the protein.
Approximately 20% of the drug is excreted with urine, and 80% is excreted with intestinal contents.
Dosing and administration
The solution is administered by the intravenous method, struino (extremely slowly), and in addition to this it is drip (also rather slowly). There is also a method of administration by electrophoresis.
Drip Injection: 5-10 ml of the drug (10%) should be diluted in an isotonic solvent of sodium chloride (use approximately 100-200 ml) or in glucose solution (5%), then injected at a rate of 6 drops per minute.
Inkjet injections: you need to enter no more than 3-5 minutes 10% solution of the drug (a dose of 5 ml).
Duration of treatment is determined by taking into account the severity and nature of the disease, as well as the effectiveness of the drug.
Dimensions of daily doses:
- adults: 0.5-1 g (about 5-10 ml of 10% solution);
- infants up to half a year: 50 mg (about 0.5 ml);
- infants within 7-12 months: 50-100 mg (about 0.5-1 ml);
- children within 1-3 years: 100-200 mg (approximately 1-2 ml);
- children 4-6 years of age: 200-300 mg (approximately 2-3 ml);
- children in the period of 7-12 years: 300-500 mg (about 3-4 ml).
The medicine is required to be administered 3-4 times a day.
After IV injection of the solution, a standard reaction arises - a feeling of heat in the mouth, which then spreads throughout the body.
Orally, the solution is consumed in 5-10% form, 2-3 times per day. For adults, the size of the portion is 10-15 ml, and for the child - 5-10 ml.
Use of the calcium chloride during pregnancy
Appropriate and carefully monitored tests regarding the safety and efficacy of taking pregnant women Calcium chloride has not been performed. Because of this, during pregnancy, it is allowed to use it only in situations where the benefits for women exceed the risk of complications in the fetus.
During lactation, the drug is allowed to be taken.
Side effects of the calcium chloride
As a result, intravenous injection of the therapeutic solution may develop a bradycardia, and in case of too rapid injection, ventricular fibrillation can be expected. Local manifestations - hyperemia or pain along the vein.
Side effects when using the solution orally: the appearance of heartburn, vomiting or nausea and epigastric pain, and in addition, the development of gastritis.
Interactions with other drugs
Calcium chloride can be prescribed in combination with antiallergic drugs.
On the contrary, it is forbidden to take the drug with tetracyclines.
In the case of combined use with drug blockers of Ca channels, their properties are weakened. The combination with quinidine can inhibit intraventricular conduction and increase the toxic effect of quinidine.
In therapy with cardiac glycosides, it is forbidden to apply the solution parenterally - because this can potentiate the cardiotoxic effect.
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Storage conditions
Calcium chloride should be kept under standard conditions at temperatures of 15-25 ° C.
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Special instructions
Calcium chloride is very often used as a facial cleanser. Many women consider this solution to be the best peeling agent used at home - it is very cheap, but it effectively eliminates black spots from the face, and also has a rejuvenating effect on the skin.
When using the solution for medical purposes, there are also no negative reviews about it. Filling the lack of the element Ca2 +, it helps to stabilize many important for life functions.
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Attention!
To simplify the perception of information, this instruction for use of the drug "Calcium chloride" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.