Brucellosis vaccine

Brucellosis is a zoonotic infectious disease of humans through contact with a sick animal or its excrements, as well as through consumption of infected unpasteurized milk or dairy products. A brucellosis vaccine is required for professional groups (people over 18 years of age). The purpose of vaccination is to prevent goat-sheep brucellosis.

Brucellosis vaccine live dry - lyophilized culture of live microbes of the vaccine strain of Brucella Brucella abortus 19 BA, has the appearance of a homogeneous mass of white or yellowish color. Release form: 1 ml (4-10 cutaneous doses) in an ampoule. Packaging - 5 ampoules. Shelf life is 3 years. Store and transport at a temperature of up to 8 °.

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Method of administration and dosage of the vaccine against brucellosis

Vaccination against brucellosis is carried out no later than 3-4 weeks before the start of work associated with the risk of infection (time of immunity development), the maximum intensity lasts 5-6 months, duration - 10-12 months. Before vaccination, specific immunity of one of the serological or skin-allergic reactions is determined. Only persons with a negative reaction are subject to vaccination.

Vaccination is carried out in the area of the outer surface of the shoulder on the border between the upper and middle thirds, once cutaneously or subcutaneously. One dose for cutaneous administration is 2 drops and contains 1-10 ¹⁰ microbial cells, for subcutaneous administration - 0.5 ml and contains 4-10 ⁸ microbial cells. Revaccination is carried out after 10-12 months cutaneously, using half the dose (5-10 ⁹ ). The diluted vaccine, stored in compliance with aseptic rules, can be used within 2 hours.

Simultaneous cutaneous vaccination against brucellosis with vaccinations against one of the following infections is permitted: rickettsiosis, tularemia and plague.

Cutaneous vaccination is carried out using 2 drops of the vaccine applied at a distance of 30-40 mm from each other; the vaccine is diluted at the rate of 0.1 ml of saline per 1 vaccination dose. Make 6 cuts (3 longitudinal and 3 transverse) of 10 mm each with a distance of 3 mm between them, rub the vaccine in for 30 seconds and let it dry for 5 minutes. For revaccination, make 6 cuts after 1 drop.

Subcutaneous vaccination: the vaccination dose is 25 times less; the vaccine is diluted at the rate of 12.5 ml of saline per 1 dose of the vaccine for cutaneous application. The brucellosis vaccine is administered in a volume of 0.5 ml.

Reactions to the introduction and contraindications to the administration of the brucellosis vaccine

Reactions to the introduction of the brucellosis vaccine are usually minor. A local reaction to cutaneous vaccination may appear after 24-48 hours in the form of hyperemia, infiltrate, or pink-red nodules along the incisions. With subcutaneous administration, hyperemia, an infiltrate up to 25 mm in diameter, and mild pain may appear at the injection site after 12-24 hours. A general reaction occurs in the first day in 1-2% of those vaccinated and is expressed by malaise, headache, and an increase in body temperature to 37.5-38°.

In addition to the general vaccinations, the contraindications are:

• Brucellosis and brucellosis in children in the anamnesis, positive serological or skin-allergic reaction to brucellosis.
• Systemic connective tissue diseases.
• Common recurrent skin diseases.
• Allergic diseases (bronchial asthma, anaphylactic shock, Quincke's edema) in the anamnesis.