Bronholitin

Broncholitin is a combination drug that contains several active ingredients:

1. Glaucine hydrobromide: Glaucine is an alkaloid that has mucolytic (mucus thinning) and bronchodilator (bronchodilator) effects. It helps reduce the viscosity of mucus in the respiratory tract and facilitate its passage, and also improves the patency of the bronchial tubes.
2. Ephedrine hydrochloride: Ephedrine is a sympathomimetic amino substance that acts as an adrenergic agonist. It stimulates adrenergic receptors, which leads to dilation of the bronchial tubes and an increase in the volume of air entering the lungs. This component may also have a mucolytic effect and promote expectoration of mucus.
3. Basil oil: Basil oil has anti-inflammatory and antiseptic properties. It may help soothe irritation in the airways and reduce coughing.

Broncholitin is commonly used for the symptomatic treatment of respiratory diseases such as bronchitis, obstructive pulmonary disease (OPD), asthma and others. It helps relieve cough, difficulty breathing and other symptoms associated with respiratory diseases.

Before using Broncholitin or any other drug, it is important to consult your doctor or pharmacist for dosage and administration recommendations, especially if you have any underlying medical conditions or are taking medications.

Indications Broncholitina

1. Bronchitis: Inflammation of the bronchial tubes, accompanied by cough, difficulty breathing, mucus and other symptoms.
2. OBPD (obstructive pulmonary disease): A chronic lung disease characterized by difficulty breathing, coughing, shortness of breath and other symptoms.
3. Asthma: A chronic inflammatory disease of the respiratory tract, which is characterized by increased sensitivity of the bronchial tubes and a reduction in their lumen, which leads to shortness of breath, suffocation and cough.
4. Tracheobronchitis: Inflammation of the trachea and bronchial tubes, often accompanied by cough, sore throat and other symptoms.
5. Difficulty in clearing mucus: To facilitate the removal of mucus from the respiratory tract and reduce the accumulation of secretions in the throat and lungs.
6. Other respiratory infections: Broncholitin may be used to treat other respiratory infections, such as colds and influenza, that are accompanied by cough, nasal congestion and other symptoms.

Release form

Bronholitin is usually available in syrup form. The syrup provides a convenient method of administration for patients, especially children, and is easily dosed using a measuring cap or dosing syringe.

Pharmacodynamics

1. Glaucine hydrobromide:

   • Broncholytic effect: Glaucine is an alkaloid that has the ability to relax the smooth muscles of the bronchi and improve airway patency.
   • Exspectorant action: Glaucine helps to thin sputum and facilitate expectoration, which helps with respiratory diseases accompanied by the formation of sputum.

2. Ephedrine hydrochloride:

   • Bronchodilator effect: Ephedrine is a sympathomimetic amine that stimulates beta-adrenergic receptors and dilates the bronchi, improving ventilation.
   • Central nervous system stimulation: Ephedrine also has central stimulant effects, which may increase alertness and reduce fatigue.

3. Basil oil:

   • Anti-inflammatory: Basil oil has anti-inflammatory properties and may help reduce inflammation in the respiratory tract.
   • Mucolytic effect: Basil helps thin mucus and facilitate expectoration.

Pharmacokinetics

1. Glaucine Hydrobromide: Glaucine is an alkaloid that is commonly obtained from various plant species such as oregano and gooseberries. Its pharmacokinetics may depend on many factors, including pathways of metabolism, excretion, etc.
2. Ephedrine Hydrochloride: Ephedrine is a sympathomimetic amine that may have effects on adrenergic receptors. Its pharmacokinetics can also be varied and depend on many factors.
3. Basil Oil: Basil oil is typically metabolized and excreted through enzymatic pathways in the body, but the pharmacokinetics of its components can be complex and heterogeneous.

Dosing and administration

Dosage for adults:

• Adults and children over 10 years of age: Take 10 ml of syrup 3 times a day.

Dosage for children:

• Children from 3 to 10 years: Take 5 ml of syrup 3 times a day.
• Children under 3 years of age: Use of Broncholitin in children under 3 years of age is generally not recommended due to the presence of ephedrine, which can cause serious side effects in young children.

Instructions for use:

• Before use: Shake the bottle thoroughly before use to ensure the contents are homogeneous.
• After meals: It is best to take Broncholitin after meals to minimize stomach irritation.
• Duration of treatment: The duration of taking Broncholitin depends on the symptoms and recommendations of the doctor, but usually treatment should not last more than 5-7 days without consulting a doctor.

Use Broncholitina during pregnancy

The use of Broncholitin, which contains glaucine hydrobromide, ephedrine hydrochloride and basal oil, during pregnancy requires special attention and caution. Each of these ingredients has potential risks and side effects that may affect pregnancy and fetal development.

Consideration of components:

1. Glaucine hydrobromide:

   • Glaucine is used as an antitussive (antitussive) and is generally considered safe for use in adults. However, there is insufficient data on its safety and effectiveness during pregnancy.

2. Ephedrine hydrochloride:

   • Ephedrine is a stimulant and can cause blood vessels to constrict, which is potentially harmful to both mother and fetus. Ephedrine can lead to high blood pressure and other cardiovascular problems. Because of these risks, ephedrine is not generally recommended for use during pregnancy.

3. Basal oil:

   • Natural oils are often used for medicinal and relaxation purposes, but their safety during pregnancy may vary. In the case of basal oil, be aware that some essential oils may stimulate the uterus and increase the risk of premature birth or other complications.

General recommendations:

Due to the presence of ephedrine and the uncertainty of the effects of glaucine and basal oil on pregnancy, the use of Broncholithin during pregnancy should be very cautious or avoided altogether. Any treatment, especially one containing potentially risky components, should be discussed with a doctor, who can evaluate all possible risks and benefits and, if necessary, suggest safer alternatives.

Contraindications

1. Individual intolerance or allergic reaction: People with a known individual intolerance to glaucine, ephedrine, basil or any other component of the drug should avoid its use.
2. Pregnancy and breastfeeding: The safety of Broncholitin use during pregnancy and breastfeeding has not been fully established. Therefore, in order to avoid negative consequences, its use should be agreed with a doctor.
3. Children: Broncholitin may be less safe for use in young children, so it is recommended to consult a doctor before using it in children.
4. Heart and vascular diseases: Ephedrine, one of the components of Broncholitin, can increase blood pressure and increase heart rate, so the use of the drug may be contraindicated in patients with serious cardiovascular diseases.
5. Tachycardia and hypertension: The use of Broncholitin may be contraindicated in patients with tachycardia (fast heartbeat) or hypertension (high blood pressure).
6. Thyrotoxicosis: The use of Broncholitin may be contraindicated in patients with thyrotoxicosis (overactive thyroid) as ephedrine may increase the symptoms of this condition.
7. Diabetes mellitus: Broncholitin may increase blood glucose levels and its use may therefore be contraindicated in patients with diabetes mellitus.

Side effects Broncholitina

1. Nervous system:

   • Headache
   • Dizziness
   • Nervousness
   • Tremor

2. Cardiovascular system:

   • Rapid heartbeat (tachycardia)
   • High blood pressure (hypertension)
   • Arrhythmias

3. Gastrointestinal tract:

   • Tension or pain in the abdomen
   • Vomiting
   • Heartburn
   • Diarrhea or constipation

4. Skin reactions:

   • Skin rash
   • Itching
   • Hives

5. Others:

   • Insomnia
   • Dry mouth
   • Increased sweating
   • Appetite disorders

Overdose

1. Heart problems: Ephedrine can cause high blood pressure, tachycardia (fast heartbeat), arrhythmias, and even heart failure in severe overdose.
2. Central stimulant: Ephedrine has a central stimulant effect and can cause insomnia, anxiety, nervousness, dizziness, headache and even seizures.
3. Respiratory disorders: In case of overdose, dry mucous membranes, difficulty breathing and even respiratory arrest may occur due to severe narrowing of the airways.
4. Gastrointestinal disturbances: Nausea, vomiting, diarrhea and other gastrointestinal disturbances may occur.
5. Seizure syndrome: In case of severe overdose, seizures and convulsions may occur.
6. Toxic effects: Overdose of basil oil or other herbal components can also cause toxic reactions.

Interactions with other drugs

1. Sympathomimetics: Ephedrine contained in Broncholitin is a sympathomimetic amine. Interactions with other sympathomimetics, such as epinephrine, may result in increased symptoms of central nervous system and cardiovascular stimulation.
2. Monoamine oxidase inhibitors (MAOIs): Ephedrine may potentiate the effects of MAOIs, which may result in increased adrenergic activity and the risk of serious side effects.
3. Antidepressants: Interactions may occur with antidepressants such as norepinephrine and serotonin reuptake inhibitors, increasing adrenergic stimulation and increasing the risk of serious side effects.
4. Medicines that increase blood pressure: Ephedrine and glaucine may increase blood pressure. Combining them with other medications, such as decongestants or central nervous system stimulants, may increase blood pressure and cause serious complications.
5. Anticoagulants: Basil oil contained in Broncholitin may enhance the effects of anticoagulants such as warfarin and increase the risk of bleeding.