Bivalos

Bivalos helps to correct metabolic processes occurring within bone and cartilage tissues.

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Indications Bivalosa

It is used for the following painful conditions:

• osteoporosis, which develops in women in the postmenopausal stage - to prevent the occurrence of fractures;
• osteoporosis in the knee or hip joint;
• osteoporosis that occurs in men.

Along with this, the medication can be prescribed for the combined treatment of various fractures - for example, in the femoral neck area.

Release form

The release of the medicine is realized in the form of powder for the production of suspension. Inside the box usually contains 7, 14 or 28, as well as 56, 84 or 100 sachets, which have a volume of 2 g of the therapeutic component.

Pharmacodynamics

In vitro tests have shown that strontium ranelate helps form bone tissue. In addition, this element is involved in collagen binding and activates the production of components that precede osteoblasts.

The drug reduces the rate of bone tissue resorption processes, thereby preventing osteoclast differentiation. The effect of this therapeutic compound leads to the fact that instead of bone tissue destruction, its formation begins. Consequently, Bivalos activates bone tissue restoration in people with osteoporosis.

A long treatment cycle (more than 3 years) leads to an increase in the patients' biochemical markers that help form bone tissue (type I C-terminal form of propeptide procollagen), and at the same time reduces the level of markers that cause their resorption (N-terminal, as well as C-terminal form of telopeptide).

The medicine helps with osteoporosis in women at the postmenopausal stage - when the likelihood of fractures increases. It also demonstrates high efficiency in osteoarthrosis. The active component of the drug is a participant in the processes of producing cartilage matrix, and at the same time affects human chondrocytes, which slows down tissue destruction. Slowing down the resorption of subchondral tissues has a positive effect on the pathophysiological processes of osteoarthrosis.

Dosing and administration

The medicine must be taken orally. Before use, a suspension must be made from the therapeutic sachets. This mixture must be drunk in the evening, before going to bed. Doctors recommend lying down horizontally immediately after taking the medicine - this will help achieve maximum therapeutic effect.

You should take 2 g of the drug per day (corresponds to 1 sachet). To avoid overdose, you should consult a doctor before increasing the portion size. The entire treatment cycle is long. To make a suspension, you need to dissolve 1 sachet in a glass filled with water at least one third.

Since many food supplements and nutritional products contain calcium, it is necessary to stop taking them at least 120 minutes before using the medicine (because such a combination reduces the absorption of strontium ranelate and worsens its medicinal effectiveness). When using the drug in people with a deficiency of calciferol and calcium, it is necessary to use additional medications that saturate the patient's body with the required components.

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Use Bivalosa during pregnancy

This medication should not be used during pregnancy or lactation. It is not prescribed during breastfeeding because strontium ranelate is excreted in breast milk.

Contraindications

Main contraindications:

• the presence of intolerance to the components of the drug;
• thrombosis in the veins;
• VTE;
• pulmonary embolism;
• ischemic heart disease;
• immobilization;
• pathologies of cerebrovascular and arterial nature;
• increased blood pressure readings.

The drug should be used with extreme caution and only under medical supervision in people with renal insufficiency.

Side effects Bivalosa

The use of the drug may provoke the occurrence of such side effects:

• disorders in the functioning of the cardiovascular system and nervous system: convulsions or headaches and disturbances of consciousness and memory;
• disorders affecting the function of the gastrointestinal tract: vomiting, stomatitis, diarrhea, loose stools, and along with this nausea and lesions that occur in the mucous membranes (for example, mouth ulcers);
• signs of allergy: itching, eczema, rashes, hives and various dermatitis;
• other manifestations: VTE.

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Interactions with other drugs

To avoid reducing the therapeutic effect of Bivalos, you should not take this drug for at least 120 minutes after taking dairy products or milk. The same rule should be followed when combining the drug with antacids.

It should also be taken into account that the therapeutic effect of tetracyclines and quinolines is significantly weakened when combined with the drug.

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Storage conditions

Bivalos should be kept in a dry place, out of the reach of small children.

Shelf life

Bivalos can be used within 36 months from the date of manufacture of the drug.

Application for children

Bivalos is not indicated in pediatrics.

Analogues

Analogues of the drug include such drugs as Strontium ranelate, Xgeva, Prolia and Stromos with Osteogenon.

Reviews

Bivalos receives mostly positive reviews, but in some comments on forums you can still find negative opinions. They mainly indicate that the drug has a large number of side effects, and in addition, has many contraindications.