Bivalos

Bivalos contributes to the adjustment of metabolic processes occurring within the bone, and in addition to this cartilage tissue.

[1]

Indications Bivalosa

It is used for the following conditions:

• osteoporosis, developing in women at the postmenopausal stage - to prevent the appearance of fractures;
• osteoporosis in the area of the knee or hip joint;
• osteoporosis that occurs in men.

At the same time, the medication can be prescribed for the combined treatment of various fractures - for example, in the femoral neck.

Release form

The release of the drug is implemented in the form of powder for the manufacture of suspensions. Inside the box usually contains 7, 14 or 28, as well as 56, 84 or 100 sachets, which have a volume of 2 g of the therapeutic component.

Pharmacodynamics

In vitro test data demonstrated that strontium ranelate is a substance that helps to form bone tissue. At the same time, this element is a participant in the binding of collagen and activates the production of components that precede osteoblasts.

The drug reduces the rate of bone tissue resorption, which prevents the differentiation of osteoclasts. The effect of this therapeutic compound leads to the fact that instead of destroying the bone tissue, their formation begins. Consequently, Bivalos activates the restoration of bone tissue in people with osteoporosis.

A long therapeutic cycle (more than 3 years) leads to an increase in patients' values of biochemical markers that help form bone tissues (type I C-terminal propeptide procollagen form), and at the same time reduce the level of markers causing their resorption (N -terminal as well as C-terminal form of telopeptide).

The drug helps with osteoporosis in women at the postmenopausal stage - when the likelihood of fractures increases. Also demonstrates high efficacy in osteoarthritis. The active component of the drug is a participant in the processes of cartilage matrix production, and with it affects the human chondrocytes, which slows down tissue destruction. Slowing the resorption of subchondral tissues has a positive effect on the pathophysiological processes of osteoarthritis.

Dosing and administration

The drug must be taken orally. Before use, it is required to make a suspension from therapeutic sachets. It is necessary to drink this mixture in the evening, before going to bed. Doctors recommend immediately after taking the drug to lie down horizontally - this will help to achieve the maximum therapeutic effect.

For the day should be consumed 2 g of the drug (corresponding to the 1st sachet). To prevent an overdose, consult a doctor before increasing the portion size. The entire therapeutic cycle has a longer duration. To make a suspension, you need to dissolve 1 sachet inside a glass filled with at least a third of water.

Due to the fact that many food additives and nutritious foods contain calcium, it is necessary to stop taking them at least 120 minutes before using the medicine (because this combination lowers the absorption of strontium ranelate and decreases its drug efficacy). When using drugs in people with a deficiency of calciferol and calcium, it is required to use additional medications that saturate the patient's body with the required components.

[3]

Use Bivalosa during pregnancy

This medication cannot be used during pregnancy or lactation. When breastfeeding it is not prescribed, because strontium ranelate is excreted in the mother's milk.

Contraindications

Main contraindications:

• the presence of intolerance in relation to the components of the drug;
• venous thrombosis;
• WD;
• TOMAS;
• ischemic disease;
• immobilization;
• pathologies with cerebrovascular and arterial character;
• increased blood pressure.

Extremely carefully and exclusively under medical supervision, the medicine is used in people with renal insufficiency.

Side effects Bivalosa

The use of a drug may cause the following side effects:

• disorders in the work of the cardiovascular system and NS: convulsions or headaches, and disorders of consciousness and memory;
• disorders affecting the function of the gastrointestinal tract: vomiting, stomatitis, diarrhea, diarrhea, and with it nausea and lesions that occur in the mucous membranes (for example, mouth ulcers);
• allergy symptoms: itching, eczema, rashes, urticaria and various dermatitis;
• Other manifestations: VTE.

[2]

Interactions with other drugs

To avoid a decrease in the therapeutic effect of Bivalos, one should not use this drug for at least 120 minutes after taking dairy products or milk. The same rule should be followed when combining the drug with antacids.

It should also be borne in mind that the therapeutic effect of tetracyclines and quinolines is significantly weakened in the case of their combination with medication.

[4], [5]

Storage conditions

Bivalos is required to keep in a dry place, closed from the penetration of small children.

Shelf life

Bivalos can be used within 36 months from the date of manufacture of the drug.

Application for children

Bivalos is not prescribed in pediatrics.

Analogs

Analogues of the medication are such drugs as Strontium ranelat, Ixjeva, Prolia and Stromos with Osteogenon.

Reviews

Bivalos for the most part receives positive feedback, but negative comments can still be found in some comments on the forums. Basically, they indicate that the medication has a large number of adverse symptoms, and in addition has many contraindications.