Bisoprol

Bisoprol is a highly selective drug that blocks the activity of β1-adrenoreceptors. When used in medicinal doses, it does not exert an internal sympathomimetic effect and does not have strong membrane-stabilizing activity. [ 1 ]

The drug has antihypertensive and antianginal effects; reduces myocardial oxygen demand, decreasing heart rate and cardiac output. Due to the decrease in end-diastolic pressure and prolongation of diastole, the volume of oxygen entering the myocardium increases. [ 2 ]

Indications Bisoprol

It is used to treat coronary heart disease ( angina ), elevated blood pressure and CHF with systolic left ventricular dysfunction (in combination with diuretics and ACE inhibitors, and, if necessary, with SG).

Release form

The medication is produced in the form of tablets of 2.5, 5 and 10 mg (20, 30 or 50 pieces per pack).

Pharmacodynamics

The maximum therapeutic effect of bisoprolol develops after 3-4 hours from the moment of drug administration. The maximum hypotensive effect develops after 2 weeks of taking Bisoprolol. [ 3 ]

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Dosing and administration

The medicine is prescribed for oral administration, the tablet is not chewed, it is swallowed whole with water. The medicine should be taken in the morning on an empty stomach (or with breakfast). If necessary, the tablet can be divided into 2 equal portions.

The standard dosage for elevated blood pressure is 5 mg once a day; the maximum dose is 20 mg once a day. For moderate increases in blood pressure, a dosage of 2.5 mg can be used.

The portion size is selected and adjusted by the attending physician.

• Application for children

The medication is not prescribed in pediatrics.

Use Bisoprol during pregnancy

Use during pregnancy

The drug can be used during pregnancy only in cases where the potential benefit to the woman is more likely to outweigh the risks of negative consequences for the fetus.

It is prohibited to prescribe the drug during breastfeeding, since there is no confirmed information that it is safe for infants.

Contraindications

Main contraindications:

• active form of heart failure or decompensated heart failure requiring inotropic treatment;
• cardiogenic shock;
• SSSU;
• AV block 1st and 3rd degree;
• pronounced sinoatrial block;
• symptomatic bradycardia;
• symptomatic decrease in blood pressure;
• severe asthma;
• late stages of peripheral circulatory disorder or Raynaud's syndrome;
• psoriasis;
• untreated pheochromocytoma;
• metabolic form of acidosis;
• severe intolerance to bisoprolol or other components of the drug.

Side effects Bisoprol

Side effects include:

• sleep disorders, fatigue, depression, headache and dizziness. Hallucinations occasionally occur;
• conjunctivitis, visual disturbances and decreased lacrimation are occasionally observed;
• decompensation of heart failure with the appearance of peripheral edema, bradycardia, decreased peripheral blood flow, AV conduction disorder. Orthostatic collapse develops occasionally. Sometimes paresthesia and a feeling of cold in the extremities appear;
• dyspnea occasionally occurs in individuals with a tendency to develop bronchial spasms (for example, in the case of asthmatic bronchitis);
• constipation, abdominal pain, diarrhea, nausea and hepatitis;
• development of cramps and muscle weakness, as well as joint damage (mono- or polyarthritis and arthropathy) is possible;
• sometimes itching appears. Occasionally hyperhidrosis, rashes and redness of the epidermis may occur;
• erectile dysfunction.

Overdose

In case of poisoning with Bisoprolol, immediate medical attention is required. In case of overdose, bradycardia, 3rd degree AV block and dizziness may be observed.

Often, intoxication causes the following symptoms: active heart failure, hypoglycemia, decreased blood pressure, bronchial spasm and bradycardia.

The drug should be discontinued and symptomatic and supportive measures should be implemented.

Interactions with other drugs

The medication potentiates the activity of other antihypertensive drugs.

When used with verapamil, reserpine, amiodarone, SG, diltiazem, clonidine, quinidine substances and α-methyldopa, the risk of developing disorders of cardiac conduction, automaticity and contractility increases.

Administration together with dihydropyridine calcium antagonists (especially in people with latent heart failure) increases the likelihood of cardiac decompensation and hypotension, which is why intravenous administration of Ca antagonists and antiarrhythmic drugs is prohibited when using Bisoprolol.

Combination with sympathomimetics, xanthines and rifampicin leads to a decrease in the half-life.

Ergotamine derivatives increase peripheral blood flow disorders.

The drug is incompatible with MAOI substances.

The effect of insulin and orally administered antidiabetic drugs may be potentiated when administered together with the drug (increasing the likelihood of hypoglycemia).

Storage conditions

Bisoprolol should be stored in a place closed to small children. Temperature indicators - no more than 25 ° C.

Shelf life

Bisoprolol can be used for a period of 36 months from the date of manufacture of the medicinal substance.

Analogues

Analogues of the drug are Bicard, Dorez with Biprolol, Coronal and Bisoprolol with Cordinorm, as well as Concor.