Beviplex

Beviplex is a medicine for the treatment and prevention of vitamin B deficiency. Let's consider the main indications for its use, dosage, and possible side effects. The drug affects tissue metabolism processes at the cellular level. Its pharmacological group is multivitamins.

Beviplex is a vitamin complex of group B. These substances are part of the enzymes responsible for regulating the metabolism of proteins, fats and carbohydrates in the body.

Indications Beviplex

Vitamin B is involved in many vital processes in the body. Since Beviplex is a multivitamin of this group of substances, let us consider the indications for its use.

• Hypovitaminosis (stomatitis, pellagra, cheilitis, glossitis).
• Complex therapy of neurological pathologies (neuritis, radiculitis, neuralgia, peripheral paralysis, diabetic polyneuropathy, disorders caused by chronic alcoholism).
• Primary vitamin B deficiency caused by an unbalanced diet.
• Secondary deficiency of vitamin B, which occurs due to disturbances in absorption in the intestine and gastrointestinal tract function.
• During or after prolonged use of antibiotics and drugs that impede the absorption of or release vitamin B from the body (oral contraceptives, Hydralazine, Isoniazid, Cycloserine).
• Pregnancy and breastfeeding (vitamin deficiency can provoke uncontrollable vomiting in women and cause severe toxicosis).
• Treatment and prevention of dermatological diseases (dermatoses, photodermatoses, itching of various etiologies, eczema, neurodermatitis, psoriasis).
• Ophthalmological pathologies (corneal opacity, conjunctivitis, keratitis).
• Complex treatment of endarteritis.
• For spasms of peripheral vessels.
• After X-ray irradiation.
• As a general tonic for liver diseases, asthenia, neurasthenia, and nutritional disorders.

The medication can be used as a preventive measure during long-term reduction diets (uremia, diabetes mellitus), with a carbohydrate-rich diet, increased mental or physical stress, in the pre- and postoperative period.

Release form

The drug has several forms of release, which allows it to be used for patients of all ages and for different indications. Beviplex is released in the form of tablets for oral administration and in the form of lyophilized powder for the preparation of an injection solution.

• Pills

The package contains 2 blisters with 15 enteric-coated dragees. One capsule contains: 4 mg thiamine hydrochloride (B1), 5 mg riboflavin sodium phosphate (B2), 2 mg pyridoxine hydrochloride (B6), 0.001 mg cyanocobalamin (B12), 5 mg calcium pantothenate, 20 mg p-aminobenzoic acid and 25 mg nicotinamide (vitamin PP).

• Powder for injection

The package contains 5 ampoules and a solvent (water for injection 2 ml). One ampoule contains: 10 mg calcium pantothenate, 100 mg nicotinamide, 4 mg cyanocobalamin, 8 mg pyridoxine hydrochloride, 40 mg thiamine hydrochloride and 4 mg riboflavin sodium phosphate.

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Pharmacodynamics

The physiological effect of the drug is observed immediately after its entry into the body. The pharmacodynamics of the enzymes included in Beviplex regulates the metabolic processes of fats, proteins and carbohydrates. The vitamin complex controls the transport of Na+ through neuronal membranes. The active components participate in the oxidative decarboxylation of pyruvic and a-ketoglutaric keto acids.

B vitamins participate in the transfer of glycolaldehyde radical to aldosacarbamates. They restore nitrogen balance and keto acid levels. This improves the functioning of the nervous, digestive and cardiovascular systems. The active substances are destroyed by the enzyme thiaminase (found in raw fish), contact with carbon disulfide accelerates the elimination process.

Pharmacokinetics

Since Beviplex contains a complex of B vitamins, each component undergoes its own transformations. Pharmacokinetics for oral administration indicate that the drug is absorbed in the initial sections of the small intestine, usually in the duodenum. 10-15 minutes after administration, the active components are found in the blood plasma, and 30 minutes later - in the body tissues. The vitamin accumulates in skeletal muscles, adrenal glands, liver, brain, kidneys and heart. About 50% of the dose taken is contained in muscle tissue.

After entering the liver, the vitamin is transformed into active metabolites: diphospho- and triphosphotiamine. It is excreted at an average rate of up to 1 mg/day due to metabolism in the liver. The half-life is 9-18 days.

Dosing and administration

To achieve a stable therapeutic effect, the method of administration and doses of Beviplex are selected by the attending physician. For therapeutic purposes, adults are prescribed 3-4 pills per day, and for prevention, 1-2 pcs. For elderly patients, 1-2 tablets per day. For children, 1-3 capsules per day (the dosage depends on the child's age). During pregnancy and lactation - 1-2 tablets per day.

Injections are administered intravenously, intramuscularly, and drip. For adults, 1-2 ampoules per day, for children and pregnant women, according to medical indications. The duration of treatment depends on the results obtained and the doctor's recommendations.

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Use Beviplex during pregnancy

Beviplex is approved for use during pregnancy and lactation. This vitamin complex is recommended to be taken even at the stage of planning a child. The drug nourishes the tissues and cells of the fetus, preventing delayed development and pathologies of the nervous system.

The medication is allowed throughout pregnancy, as it ensures the exchange of amino acids that create protein. This substance is involved in the construction of organs and tissues of the future child, improves the functioning of many systems of the mother and fetus. B vitamins reduce stress, which helps a woman to endure pregnancy more easily, preventing the development of psychoses and nervousness.

The use of the drug in the last months of pregnancy alleviates the woman's condition, as the fetus begins to press heavily on the uterus. Vitamin B deficiency can lead to the development of neurological disorders and other pathologies.

Contraindications

Since Beviplex contains several active components, it has certain contraindications for use, which apply to both tablets and injections. The drug is not used in case of hypersensitivity to B vitamins and other components of the drug. The vitamin preparation is not used during Levodopa therapy.

Side effects Beviplex

Long-term use of the drug or failure to comply with the dosage recommended by the doctor causes side effects. Most often, these are allergic reactions: skin itching, rashes, hyperemia.
Injections can cause pain at the injection site, the formation of post-injection abscesses, severe anaphylactic reactions.

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Overdose

The use of increased doses of the drug may cause adverse reactions. Overdose most often manifests itself in the gastrointestinal tract, causing bouts of nausea and vomiting. Sleep problems, skin allergic reactions, and even anaphylactic shock are possible.

Treatment is symptomatic; there is no specific antidote.

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Interactions with other drugs

The simultaneous use of several drugs in the treatment of a certain disease accelerates the recovery process. The interaction of Beviplex with other drugs is possible with appropriate medical indications.

• Medicines containing antacids can be taken 2 hours after Beviplex, as it slows down absorption.
• Multivitamins reduce the antiparkinsonian effect of Levodopa, the level of Pyridoxine, Penicillin, Cycloserine and anticonvulsants (Phenytoin, Phenobarbital).
• Oral contraceptives reduce drug levels, and tricyclic antidepressants (Dexorubicin, Chlorpromazine) inhibit the transformation of vitamin B2 into flavin adenine dinucleotide and flavin mononucleotide.
• General anesthetics, anti-tuberculosis, anti-epileptic, anti-hyperlipidemic drugs and alcohol reduce the level of vitamin B in the blood.

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Storage conditions

The drug must be kept in its original packaging, protected from moisture, sunlight and out of reach of children. Storage conditions require maintaining a temperature regime of - 25º C. Failure to comply with these recommendations leads to deterioration of the drug and loss of its pharmacological properties.