Beviplex

Beviplex is a medicinal product for the treatment and prevention of vitamin B deficiency. Consider the main indications for its use, dosage, possible side effects. The drug affects the processes of tissue metabolism at the cellular level. His pharmacological group is multivitamins.

Beviplex is a vitamin complex of group B. These substances are part of the enzymes responsible for regulating the metabolism of proteins, fats and carbohydrates in the body.

Indications Beviplex

Vitamin B is involved in many vital processes in the body. As Beviplex belongs to the multivitamins of this group of substances, we will consider the indications for its use.

• Hypovitaminosis (stomatitis, pellagra, cheilitis, glossitis).
• Complex therapy of neurological pathologies (neuritis, radiculitis, neuralgia, peripheral paralysis, diabetic polyneuropathy, disorders caused by chronic alcoholism).
• The primary disadvantage of vitamin B, caused by an unbalanced diet.
• Secondary deficiency of vitamin B, which occurs when violations of absorption in the intestine and the work of the digestive tract.
• During or after a prolonged use of antibiotics and drugs that hamper the absorption or excretion of vitamin B (oral contraceptives, hydralazine, isoniazid, cycloserine).
• Pregnancy and breastfeeding (vitamin deficiency can provoke uncontrolled vomiting in a woman and cause severe toxicosis).
• Treatment and prevention of dermatological diseases (dermatosis, photodermatosis, itching of various etiologies, eczema, neurodermatitis, psoriasis).
• Ophthalmic pathologies (corneal opacity, conjunctivitis, keratitis).
• Complex treatment of endarteritis.
• With spasms of peripheral vessels.
• After X-ray irradiation.
• As a restorative for diseases of the liver, asthenia, neurasthenia, malnutrition.

The medication can be used as a preventive agent for long-term adherence to reduction diets (uremia, diabetes mellitus), with a carbohydrate-rich diet, increased mental or physical stress, in the pre and postoperative period.

Release form

The drug has several forms of release, which allows it to be used for patients of all ages and with different indications. Beviplex is released in the form of tablets for oral administration and in the form of lyophilized powder for the preparation of a solution for injection.

• Pills

In the package there are 2 blisters of 15 pills with an enteric coating. The capsule contains 4 mg of thiamine hydrochloride (B1), 5 mg of riboflavin sodium phosphate (B2), 2 mg of pyridoxine hydrochloride (B6), 0.001 mg of cyanocobalamin (B12), 5 mg of calcium pantothenate, 20 mg of p-aminobenzoic acid and 25 mg of nicotinamide (vitamin PP).

• Powder for Injection

The package contains 5 ampoules and a solvent (water for injection 2 ml). One ampoule contains: 10 mg of calcium pantothenate, 100 mg of nicotinamide, 4 mg of cyanocobalamin, 8 mg of pyridoxine hydrochloride, 40 mg of thiamine hydrochloride and 4 mg of riboflavin sodium phosphate.

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Pharmacodynamics

The physiological effect of the drug is observed immediately after it enters the body. Pharmacodynamics of the enzymes that make up Beviplex regulates the metabolic processes of fats, proteins and carbohydrates. The vitamin complex controls the transport of Na + through neuronal membranes. The active components take part in the oxidative decarboxylation of pyruvic and a-ketoglutaric keto acids.

Vitamins of group B are involved in the transfer of the glycolaldehyde radical to aldosugars. Restore the nitrogen balance and the level of keto acids. This improves the functioning of the nervous, digestive and cardiovascular systems. The active substances are destroyed by enzyme thiaminase (included in raw fish), contact with carbon disulphide accelerates the excretion process.

Pharmacokinetics

Since Beviplex contains a complex of B vitamins, each component undergoes its own transformations. Pharmacokinetics for oral use indicates that the drug is absorbed in the initial parts of the small intestine, usually in the duodenum. After 10-15 minutes after taking the active components are found in the blood plasma, and after 30 minutes - in the tissues of the body. Vitamin is accumulated in skeletal muscles, adrenal glands, liver, brain, kidneys and heart. About 50% of the dose is contained in muscle tissue.

After entering the liver, the vitamin is transformed into active metabolites: diphospho- and triphosphothiamine. It is excreted at an average rate of up to 1 mg / day due to metabolism in the liver. The half-life is 9-18 days.

Dosing and administration

To achieve a stable therapeutic effect, the method of application and dose of Beviplex is chosen by the attending physician. For therapeutic purposes, adults are prescribed 3-4 tablets a day, and for prevention, 1-2 pills. For elderly patients, 1-2 tablets per day. For children, 1-3 capsules per day (dosage depends on the child's age). During pregnancy and lactation - 1-2 tablets a day.

Injections are administered intravenously, intramuscularly, and drip. For adults, 1-2 ampoules a day, for children and pregnant women for medical reasons. The duration of treatment depends on the results and recommendations of the doctor.

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Use Beviplex during pregnancy

Beviplex is approved for use during pregnancy and lactation. This vitamin complex is recommended to be taken at the planning stage of the child. The drug nourishes the tissues and cells of the fetus, preventing the slow development and pathology of the nervous system.

The medication is allowed during the entire pregnancy, as it ensures the exchange of amino acids that create the protein. This substance is involved in the construction of organs and tissues of the unborn child, improves the functioning of many systems of the mother and fetus. B group vitamins reduce stress, which helps a woman to bear bearing, preventing the development of psychosis, nervosa.

The use of the medicine in the last months of pregnancy facilitates the condition of the woman, since the fetus begins to put a heavy pressure on the uterus. Deficiency of vitamin B can lead to the development of neurological disorders and other pathologies.

Contraindications

Since Beviplex contains several active components, it has certain contraindications for use, which apply to both tablets and injections. The drug is not used for hypersensitivity to Group B vitamins and other components of the drug. With Levodopa therapy, a vitamin preparation is not used.

Side effects Beviplex

Prolonged use of the drug or non-compliance with the recommended dosage by the doctor causes side effects. Most often, allergic reactions: skin itching, rashes, hyperemia.
Injections can cause painful sensations at the injection site, the formation of post-injection abscesses, severe anaphylactic reactions. 

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Overdose

The use of elevated doses of the drug may cause unwanted reactions. Overdose is most often manifested from the gastrointestinal tract, causing attacks of nausea, vomiting. Possible problems with sleep, skin allergic reactions and even anaphylactic shock.

Treatment is symptomatic, there is no specific antidote. 

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Interactions with other drugs

The simultaneous use of several drugs in the therapy of a particular disease speeds up the process of recovery. Interaction Beviplex with other drugs is possible with appropriate medical indications.

• Drugs with antacids can be taken 2 hours after Beviplex, as it slows down absorption.
• Multivitamins reduce the anti-Parkinsonian action of Levodopa, the level of Pyridoxine, Penicillin, Cycloserin and anticonvulsants (Phenytoin, Phenobarbital).
• Oral contraceptives reduce the level of medication, and tricyclic antidepressants (Dexorubicin, Chlorpromazine) inhibit the transformation of vitamin B2 into flavinadenidine dinucleotide and flavin mononucleotide.
• General anesthetics, anti-tuberculosis, antiepileptic, antihyperlipidemic drugs and alcohol reduce the level of vitamin B in the blood.

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Storage conditions

The drug should be kept in its original packaging, protected from moisture, sunlight and inaccessible to children. Storage conditions assume compliance with the temperature regime - 25º C. Failure to comply with these recommendations leads to damage to the medicine and loss of its pharmacological properties.