Benzohexonium

Benzohexonium is a ganglion-blocking drug.

[1], [2], [3]

Indications Benzohexonium

Among the indications for his appointment: a sharp and rapid increase in blood pressure (hypertensive crisis), as well as an artificial lowering of the level of blood pressure under control (controlled hypotension).

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Release form

Produced in tablet form, as well as in the form of a solution. Tablets of 0.1 g contain 20 pieces per 1 pack. Ampoules with a volume of 1 ml (a solution of 2.5%) can be contained in 1 package in an amount of 6 or 10 pieces.

[5], [6], [7]

Pharmacodynamics

The drug is a ganglion blocker that blocks n-cholinergic receptors located in the vegetative nodes, and in addition it slows the process of carrying out the nerve impulse (from preganglionic to postganglionic endings). Together with this suppresses the carotid bodies and adrenal chromaffin tissue, as a result of which the resulting reflex pressor effect decreases. It provokes a decrease in intestinal motility, blood pressure level, urea tone, external secretion, and also accommodation paresis. In addition, it speeds up heart rate and enlarges the bronchi.

Pharmacokinetics

The medicine is slowly and not completely absorbed in the intestine, therefore, it is usually injected parenterally. The active substance does not pass through the placenta and the BBB.

After IV introduction, the plasma concentration level decreases very rapidly. Immediately for the first day, together with urine, up to 90% of the drug is excreted. The rate of excretion in the first few hours after the injection is maximal.

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Dosing and administration

When taking orally, the dosage is 2-3 times a use of 0.1-0.2 grams of LS (the frequency of reception may be higher).

To eliminate the hypertensive crisis, you need to inject a solution in / m and / or in a dosage of 0.5-1.0 ml. A single dosage can not exceed 0.3 g, and a daily dosage does not exceed 0.9 g. With a subcutaneous method of administration, a single dosage is not more than 0.075 g, and a daily dosage is no more than 0.3 g.

With controlled hypotension, the drug is administered IV (for 2 minutes) at a dosage of 1-1.5 ml. The drug begins 12-15 minutes later. If necessary, you can add the solution.

[13], [14], [15],

Use Benzohexonium during pregnancy

Benzohexonium can not be administered during lactation, and pregnancy.

Contraindications

Among the contraindications:

• severe intolerance to drug components;
• low blood pressure;
• hypovolemia, and also shock;
• acute form of myocardial infarction;
• pheochromocytoma;
• ischemic stroke (no more than 2 months);
• presence of thromboses (also inside the arteries of the brain);
• glaucoma of the closed type;
• kidney or liver failure;
• The presence of degenerative changes in the central nervous system.

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Side effects Benzohexonium

As a result of using the medicine, there are possible side reactions:

• organs of the central nervous system: the appearance of dizziness or weakness, the development of mydriasis or dysarthria, short-term memory impairment, and respiratory depression;
• organs of the cardiovascular system: the development of tachycardia, pain in the heart, acceleration of the pulse, orthostatic hypotension (can go to collapse), and in addition, the injection of vessels of the eye sclera;
• Gastrointestinal organs: constipation, dryness in the oral cavity, difficulty in swallowing. With prolonged use, intestinal atony can develop, as well as paresis of the gallbladder;
• organs of the urination system: after prolonged use - atony of the urethra or a disorder of the urinary function, in which there is a stagnation of urine, which contributes to the occurrence of cystitis.

[10], [11], [12]

Overdose

As a result of an overdose, orthostatic collapse may develop.

To eliminate the disturbance, the patient should be given the following position - to lower his head and raise his legs. Then, low doses of fetanol, mezaton or ephedrine, as well as caffeine and cordiamine are administered.

Interactions with other drugs

Antagonists of the drug are drugs that provoke vomiting, cholinesterase inhibitors, and in addition n-cholinostimulators.

Benzohexonium increases the effect of antihistamines and adrenomimetic drugs, and in addition to sleeping pills and sedatives, as well as antipsychotics and opiates. In addition to these drugs increases the effectiveness of tricyclics, local anesthetics, vasodilating and other antihypertensive drugs.

Intensifies insulin intolerance in patients with diabetes mellitus.

[16], [17], [18], [19], [20]

Storage conditions

Keep the medicine in the original, tightly sealed package. The temperature in the room should not exceed 25 ^o C.

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Shelf life

Benzohexonium is suitable for use within 4 (solution) and 5 (tablet) years from the date of manufacture.