Benzonal

Benzonal is an anticonvulsant, which increases the slowing GABAergicheskoe impact inside the central nervous system.

[1], [2], [3], [4], [5], [6]

Indications Benzonal

Among the indications of the medicine:

• epilepsy in convulsive forms, having a different nature (especially if the focus of the pathology is localized in the cerebral cortex);
• seizures of polymorphic or non-convulsive type (taken in combination with other antiepileptic drugs);
• functional forms of hyperbilirubinemia (among them and developing after hepatitis);
• Gilbert's syndrome;
• chronic stage of hepatitis in a cholestatic form;
• a benign form of recurrent cholestasis;
• superhepatic jaundice.

[7], [8], [9]

Release form

Produced in tablet form. The volume of tablets for adults is 0,1 g, and for children's tablets - 0,05 g. One blister contains 10 tablets, in the package - 5 blister plates.

[10]

Pharmacodynamics

The drug helps reduce the frequency of epileptic seizures. In addition, it enhances the activity of the microsomal system of hepatic enzymes and the processes of glucoronization with acetylation. Also, the medicine accelerates the process of biotransformation of external and internal compounds, among which bilirubin.

[11]

Pharmacokinetics

In the process of metabolism, the substance phenobarbital is formed, which possesses anti-epileptic properties. Synthesis with proteins inside the plasma is rather weak.

The drug in high concentrations is determined in the kidneys with the liver and brain. Passes through gistogematicheskie barriers, but also penetrates into the mother's milk. The half-life is 3-4 hours.

Excretion is carried out through the kidneys, the substance goes unchanged, as well as in the form of decay products.

[12], [13], [14], [15]

Dosing and administration

Use the medicine after eating, orally. Dosages are selected depending on the regularity and nature of seizures occurring, as well as the age of the patient.

Adults - 0.1 g three times a day (the maximum daily dosage is 0.8 g), children (also three times a day): in the age category 3-6 years - to 0.025-0.05 g, in the period of 7 -10 years - to 0.05-0.1 g, at the age of 11-14 years - 0.1 g (for a day not more than 0.45 g).

The treatment course begins with a single dose of a single dose, and then, after 2-3 days, the amount of the daily dose begins to gradually increase to the optimal level. The duration of drug use in the maintenance dosage is individual, and depends on the therapeutic effectiveness of the drug. It is recommended to take the pill for at least 2 years (even if the seizures have already stopped).

To eliminate hyperbilirubinemia, you should drink tablets for 2-3 weeks at the same dosages that are prescribed for the treatment of epilepsy.

Use Benzonal during pregnancy

In pregnancy, the use of Benzonal is contraindicated.

Contraindications

Among the contraindications:

• disorders in the work of the liver or kidneys in severe form;
• 2-3 stage of heart failure in chronic form;
• presence of bronchial asthma, anemia, diabetes, porphyria, and in addition to adrenal or respiratory failure;
• development of depression (with suicide attempts), hyperkinesis;
• intolerance to the benzobarbital component.

[16]

Side effects Benzonal

As a result of the use of drugs can develop such side effects: sleep disorders, feelings of drowsiness or lethargy, speech problems, inhibition of mental reactions, worsening appetite, development of ataxia or nystagmus.

[17], [18], [19], [20]

Overdose

An indication of a drug overdose is an increase in its side effects.

To eliminate the violations you need to perform a gastric lavage, give the patient activated charcoal, and then conduct a treatment aimed at getting rid of the symptoms.

[21],

Interactions with other drugs

The medicine increases the effect of antipsychotics, tricyclics, hypnotic drugs, narcotic analgesics, anesthetics, and in addition to ethyl alcohol and tranquilizers.

As a result of combined use with Benzonal, the effectiveness of tetracycline drugs, paracetamol, GCS, xanthines, anticoagulants, mineralocorticosteroids, griseofulvin, quinidine, and cardiac glycosides and calciferol decreases.

Combination with drugs with mielodepressivnyh properties, causes an increase in the hematotoxic effect.

[22],

Storage conditions

The medicine is required to be kept in a place that is standard in terms of its conditions for medicines. Temperature - not more than 25 ° C.

[23],

Shelf life

Benzonal is allowed to be used within 4 years from the date of release of the drug.

[24], [25], [26]