Bekotid Evohaler

Bekotid Evohaler is an anti-asthmatic preparation for inhalations. Consider the conditions for its use: indications, dosage, side effects, storage conditions.

The inhaler is the best way to stop asthmatic attacks, as it delivers medicinal substances directly to the bronchial system. An asthmatic attack is a dangerous condition, for which urgent help is needed. Tablets, syrups, injections and other forms of medication do not have an instant effect unlike inhalations.

Another advantage of the inhaler is its ease of use and safety. It is suitable for the treatment of asthmatic attacks in patients of any age. Bekotid Evohaler is included in the category of hormonal drugs, since its active ingredient is a glucocorticosteroid. It reduces the inflammatory process in the body and removes the swelling from the mucous membranes, making breathing easier.

[1], [2]

Indications Bekotid Evohaler

The main indication for the use of Beckotid is the basic treatment of bronchial asthma in adults and children. The drug is prescribed for:

• Recurrent attacks of asthma
• Treatment and prevention of bronchospasm
• Asthma of a chronic nature

The inhaler is suitable for relieving asthma attacks of mild, moderate and severe severity. 

[3], [4], [5], [6]

Release form

Bekotid Evohaler has a release form - an inhaler. Each dose of aerosol contains - beclomethasone dipropionate 50 μg. Auxiliary components are: HFA 134a, ethanol and glycerol. One cylinder is enough for 100 doses-injections.

[7]

Pharmacodynamics

The active substance of the drug - beclomethasone dipropionate, is a precursor of the active component, similar to glucocorticosteroid receptors. Pharmacodynamics is indicated for hydrolysis with esterases with the formation of a metabolite - beclomethasone-17-monopropionate. The obtained substance has local anti-inflammatory activity.

[8], [9], [10], [11]

Pharmacokinetics

Bekotid is used for inhalation. Pharmacokinetics indicates a low systemic absorption of the dose passing through the lungs and trapped in the digestive tract. During the absorption process, the active ingredient is converted to an active metabolite. Its systemic absorption consists of absorption in the digestive tract and lungs. Bioavailability of inhalation application - 60%.

Beclomethasone dipropionate is rapidly excreted from the systemic blood stream. The volume of distribution and binding to plasma proteins is moderately high. The drug has a high clearance, half-life of 30 to 90 minutes. 60% of the accepted dose is excreted with feces, 12% with urine. Kidney clearance is insignificant.

[12], [13]

Dosing and administration

This anti-asthmatic drug means an inhalation route of administration. Doses of Becotid depend on the severity of pathological symptoms and the individual reaction to the medication. With mild asthma, 200-600 mcg, with an average of 600-1000 mcg and with a heavy dose of 1000-2000 mcg per day in proportional doses.

If the medicine is used to prevent asthma attacks, then it should be used on a regular basis, even in the absence of seizures. In the treatment of children, a spacer nozzle can be used to facilitate the inhalation of the inhalation agent. To stop the use of the drug is necessary gradually, this will avoid the side effects of glucocorticosteroids.

[20], [21], [22]

Use Bekotid Evohaler during pregnancy

Safety of use of becotide during pregnancy is not established. The possibility of application is determined by the expected benefit for the mother, taking into account the potential risks to the fetus. The active substance in small amounts is excreted in breast milk, therefore the inhaler is not recommended for breastfeeding. 

Contraindications

Inhaler Bekotid is contraindicated for use in cases of intolerance of the components of its composition. The drug is not prescribed for bleeding in the lungs, hemoptysis, diseases of the cardiovascular system, hypertension severe, with violations of hematopoiesis and emphysema.

Inhalation is not recommended in post-stroke or post-infarction period, as well as at elevated temperature. With special care, the drug is prescribed for patients with latent or active pulmonary tuberculosis.

[14], [15], [16]

Side effects Bekotid Evohaler

Incorrect use of the drug causes side effects. Bekotid can cause such reactions:

• Candidiasis of the oral cavity and pharynx.
• Skin allergic reactions (burning, itching, hyperemia).
• Edema of the oropharynx, eye, face.
• Respiratory and anaphylactic reactions.
• Oppression of adrenal function.
• Glaucoma and cataract.
• Growth retardation in patients of childhood and adolescence.
• Sleep disturbances and increased anxiety.
• Stimulation of the throat and hoarseness of the voice.
• Paradoxical bronchospasm (occurs very rarely).

Symptomatic therapy is indicated to eliminate the above reactions.

[17], [18], [19]

Overdose

The use of elevated dosages causes adverse symptoms. Overdose Becotid manifests itself as a temporary oppression of the function of the adrenal cortex. This condition does not require emergency care, since the body recover within a few days, which is confirmed by the level of cortisol in the blood plasma.

[23], [24], [25]

Interactions with other drugs

The composition Bekotid Evohaler includes ethanol, therefore, when interacting with other drugs, it is necessary to take into account the possibility of developing hypersensitivity reactions. The drug is not recommended to be used simultaneously with Metronidazole or Disulfiram.

[26], [27], [28]

Storage conditions

Aerosol can for inhalation should be kept away from direct sunlight and out of reach of children. Storage conditions assume compliance with the temperature regime of no higher than 30 ° C. The drug should not be frozen and kept near an open flame.

To prevent premature spoilage, after each inhalation, the can should be tightly closed with a lid and stored in its original packaging.

[29], [30], [31], [32], [33], [34], [35]

Shelf life

Bekotid Evohaler must be used within 24 months from the production date. Shelf life is indicated on the package and spray can. At its expiration, the medicine must be disposed of. The inhaler used is contraindicated to be thrown into a fire or smashed.

[36], [37]