Batrafen

Batrafen - a drug for the treatment of fungal skin lesions. Let us consider in more detail his instructions, indications for use, side effects, dosage. The drug refers to antimicrobial and antiparasitic drugs. Clinico-pharmacological group - antifungal agents for the treatment of fungal diseases.

Batrafen contains an active substance - cyclopyrox with a wide range of action against fungal microorganisms. It is sensitive to fungi of the genus Candida, histoplasm, pathogens of mycetoma, trichophytosis, epidermophytia. Antibacterial activity is manifested in the form of sensitivity to mycoplasma, Trichomonas and Gram-negative flora.

[1], [2], [3]

Indications Batrafen

The drug is effective in the treatment of fungal infections of the skin and nails, onychomycosis. Indications for use are due to the activity of its constituents. It can be used in complex therapy of various severity of skin diseases, yeast dermatoses, epidermophytosis. It is used for medical purposes.

[4]

Release form

Batrafen has two forms of release:

• Nail polish (bottles of 3, 6 g) - 1 g of lacquer contains 8 mg of cyclopyrox. As auxiliary components are: ethyl acetate, butylhydromaleate copolymer, isopropanol and others.
• Cream for application to the skin (tubes of 15, 20 g) - in 1 g of cream contains 10 mg of cyclopyrox olamine. Additional substances: octadecyl and myristyl alcohol, phenylcarbinol, α-hydroxypropionic acid, sorbitan isostearate, liquid paraffin.

[5],

Pharmacodynamics

An antifungal topical agent has a wide range of action against harmful microorganisms. Pharmacodynamics indicates activity in relation to:

• Trichophyton (rubrum, mentagrophytes, verrucosum, tonsurans, quinckeanum, equinum, oncentricum, epilans, ferrugineum, gallnae, Schoenleinii, soudanense, terrestre, violaceum)
• Microsporum (canis, gypseum, audouinii, langeroni, nanum)
• Epidermophyton floccosum
• Candida (albicans, tropicals, krusei, parapsilosis, pseudotropicalis, lipolytica, quiliermondii, brumpti, utilis, viswanathii)
• Torulopsis glabrata
• Aspergillus (flavus, niger)
• Penicillium (chrysogenum, fumigalus, notatum)
• Absidia corymbifera
• Madurella (grisca, mycetomi)
• Allescheria boydii
• Cladosporium (carrionii, trichoides)
• Philophora (jeanselmei, pedrosoi, gougeroti)
• Leptosphacria senegalensis and many other microorganisms.

The therapeutic effect is based on inhibiting the entry of fungus into the cells and inducing the removal from its cells of vital components and growth components. Antibacterial action is manifested in relation to the majority of gram-negative and gram-positive pathogens. Cyclopyrox inhibits the growth of trichomonads and mycoplasma.

[6], [7], [8]

Pharmacokinetics

The drug is intended for the treatment of fungal lesions of different etiology and severity. These pharmacokinetics indicate the suppression of significant fungal concentrations in a single application. The maximum plasma concentration is observed in fungi of the genus Candida, dermatophytes, yeast-like and mold fungi.

[9], [10]

Dosing and administration

Batrafen is used externally. The method of administration and dose depend on the medical purpose and indications. Ointment is applied to the affected areas of the skin 1 time per day until complete recovery.

Before applying the lacquer, you must remove the maximum amount of the affected nail, and treat the remaining nail plate with a nail file, creating an uneven surface. During the first month of treatment, the varnish is applied every second day, for the second month 2 times a week and for the third month - 1 time in 7 days. That is, the duration of treatment on average takes 3 months, but should not exceed six months.

Use Batrafen during pregnancy

Treatment of fungal diseases in expectant mothers presents difficulties, since many drugs are prohibited. Batrafen is contraindicated in pregnancy and lactation. To date, there is no clinical experience and reliable data on the safety of ointment use. The medication is not prescribed for patients under 10 years of age.

Contraindications

As a rule, antifungal drugs are prescribed by the attending physician, which takes into account the individual characteristics of the patient's body and the severity of the fungal lesion. Batrafen has a number of contraindications for use:

• Individual intolerance of active components
• Pregnancy and lactemia
• Age of the patient under 10 years of age

If the drug is used by patients with contraindications, then there are undesirable reactions that complicate the treatment process.

[11], [12], [13]

Side effects Batrafen

If the doctor does not comply with the recommendations, the antifungal agent causes side effects. As a rule, these are local allergic reactions:

• Itching
• Burning
• Skin irritation
• Peeling
• Hyperemia of the skin
• Peeling nails (when using a varnish)

To eliminate side effects, it is necessary to stop using the drug and seek medical help for the appointment of a suitable medication.

[14], [15]

Overdose

In spite of the fact that Batrafen belongs to antifungal drugs and has contraindications to the use, the facts of overdose have not been fixed. In rare cases, prolonged use of the ointment can cause skin allergic reactions. 

[16]

Interactions with other drugs

The medication is used topically, that is, it is applied to the affected areas of the skin and nails. Interaction with other topical preparations is contraindicated, since it can provoke allergic reactions.

Batrafen is allowed to be used with systemic antifungal agents. This interaction increases the effectiveness of both forms of the drug.

[17], [18], [19]

Storage conditions

To maintain the pharmacological properties of the drug must comply with storage conditions. Both forms of release Batrafen (varnish, ointment) should be kept in a place protected from sunlight and inaccessible to children. The recommended storage temperature should not be above 25 ° C.

If the above recommendations are not followed, the medicament loses its medicinal properties and is prohibited for use.

[20]

Shelf life

Batrafen can be used for 36 months from the date it was manufactured. Shelf life is indicated on the package, tuba with ointment and on the bottom of the vial with a varnish. At the end of this period, the medicine must not be used and must be disposed of.