Bagotiroks

Bagotyrox is a drug that belongs to the clinical and pharmacological group of thyroid hormone drugs. Let's consider the instruction on the use of the drug, in what cases are prescribed Bagotiroks, contraindications, dosage and possible side effects.

Indications Bagotiroks

Indications for use Bagotiroks based on the action of the active substance of the drug. Bagotiroks appoint at:

• Hypothyroidism
• Euthyroid goiter
• Diffuse toxic goiter
• After surgery
• For substitution therapy
• For the treatment of oncological lesions.

The drug is effective in combination therapy, as it interacts with many drugs. With the help of the drug, a test of the functions of the thyroid gland, that is, thyroid suppression, is performed. When hypothyroidism and lesions of the pituitary gland, diagnose the work of the adrenal cortex. With insufficient adrenal cortex, Bagotirox is not prescribed.

Release form

Form release Bagotyrox - tablets. One package contains one blister of the preparation for 10 tablets. Tablets have a rectangular shape with notches on each side and embossing. The drug is released at 50, 100 and 150 mcg. Dosage indicates the volume of the active substance - levothyroxine sodium.

One tablet Bagotyrox contains - levothyroxine sodium, dye, lactose monohydrate, quinoline yellow, powdered cellulose, sodium croscarmellose. Manufacturers produce Bagotiroks in carton packs, in one container 1000 pcs. Packings of the preparation.

Pharmacodynamics

Pharmacodynamics Bagotiroks are biochemical effects and physiological actions that occur with the substances of the drug when ingested. The active substance is partially converted to triiodothyronine and is metabolized in the kidney and liver. The rest of levothyroxine sodium passes into the cells of the body and affects the metabolism, growth and development of tissues.

If the drug is taken in small doses, it has an effect on protein metabolism, because of anabolic action. Bagotyrox stimulates the growth of tissues, so the body experiences a constant need for oxygen. Levotiroksin sodium increases the work of the cardiovascular system, the nervous system, accelerates metabolism. Increased dosage Bagotiroks depresses the hormones of the hypothalamus and the pituitary gland. After 7-14 days of regular use of the drug, one can observe a positive therapeutic effect, which will remain after the abolition of Bagotiroks.

Pharmacokinetics

Pharmacokinetics Bagotiroks are the processes that occur with the drug after its application. That is, it is absorption, distribution, metabolism and elimination period. After oral administration, about 80% of levothyroxine sodium is absorbed. Bagotirox should be taken before meals, as eating reduces absorption. The maximum concentration of the drug in the blood serum is observed after 5-6 hours after its administration. About 90% of the drug binds to blood proteins.

Monodeiodination occurs in different tissues of the body and is more than 80%. The drug is metabolized in the kidneys, liver, brain and muscle system. BAGOTYROX is excreted with bile and urine. The half-life and elimination period depends on the dose taken.

Dosing and administration

Dosing and Administration Bagotiroks are prescribed individually for each patient and depend on the symptomatology of the disease and the age of the patient. According to the instructions, the drug should be taken one tablet, before meals. Tablets can not be chewed and washed down with a copious amount of liquid. The daily dose of the drug depends on the indications for the use of Bagotiroks.

• If the drug is prescribed for patients younger than 50 years who do not have cardiovascular disease, the dose of Bagotiroks is 1.5-1.8 μg / kg.
• Breasts are given a daily dose of the drug before feeding. The dosage is selected by the doctor, and it depends on the weight and results of the baby's tests.
• For patients with chronic hypothyroidism, 12-12.5 μg of drug per day are prescribed. The dosage gradually increases and depends on the patient's condition during the application of Bagotiroks. Note that with hypothyroidism, treatment and prevention with Bagotiroks are quite lengthy.
• If Bagotiroks are taken with thyrotoxicosis, then a complex therapy is prescribed using thyreostatics. The duration of such treatment is determined by the physician, relying on the results of the patient's analyzes.

Use Bagotiroks during pregnancy

Use of Bagotirox during pregnancy is possible only by medical authorization and in the case when the therapeutic benefit of the drug for the mother is much more important than the potential risk to the baby. If a woman took Bagotiroks before pregnancy with hypothyroidism, then the drug should continue to be taken during the period of the child's birth and lactation. During pregnancy, the doctor increases the dosage.

If during pregnancy a combined treatment with thyreostatics is prescribed, then taking Bagotiroks is contraindicated. Since unlike levothyroxine sodium, thyrostatics penetrate the placental barrier and can cause hypothyroidism in the child.

Contraindications

Contraindications to the use of Bagotiroks sensitivity of the body to the active substance of the drug. The drug should not be taken with thyrotoxicosis and myocarditis. Bagothyrox is replaced with a safer drug with a similar therapeutic effect and pharmacodynamics. The drug is contraindicated in the failure of the adrenal cortex.

With diabetes, arrhythmia, stenocardia and prolonged hypothyroidism, Bagotiroks is appointed with extreme caution and only on medical clearance with individual selection of dosage.

Side effects Bagotiroks

Side effects of Bagotirox occur when an overdose of the drug or improper application. Very often, side effects occur in patients who take Bagotiroks, but have contraindications to its use. The main side effects are manifested as skin dermatitis, that is, an allergic reaction.

Proper use of the drug, which is under medical supervision with the observance and adjustment of dosage will prevent the occurrence of side effects. Side effects are treated symptomatically and require adjustment of the dose of the drug.

[1], [2]

Overdose

Overdose of Bagotirox occurs when the dosage of the drug is not complied with or long-term treatment. The main symptoms of an overdose are similar to the symptoms of thyrotoxicosis, it is a violation of the rhythm of the heart, increased sweating and appetite, diarrhea, flatulence, heart pain, weight loss and others.

Treatment of overdose depends on the severity of the symptoms. With minor symptoms, the doctor adjusts the daily dose of Bagotirox, reducing it. Sometimes, the drug is recommended to be discontinued for a few days so that the symptoms of an overdose go away. After the disappearance of side effects and symptoms of an overdose, the reception of Bagotiroks is restored, but with a lower daily dose.

Interactions with other drugs

Interaction of Bagotirox with other drugs is possible only for medical reasons and in the case when the drug is used in combination therapy. Let's look at how Bagotirox interacts with other drugs.

• Levotiroksin sodium enhances the therapeutic effect of indirect anticoagulants. Therefore, with this interaction, the dosage of the latter should be reduced.
• When interacting with tricyclic antidepressants, Bagotirox enhances their action, so the doctor must adjust the dose of medicines.
• Bagotyrox significantly reduces the effectiveness of cardiac glycosides. And when used with colestyramine and colestipol, the concentration of levothyroxine sodium in the blood plasma decreases. This is due to a decrease in the level of absorption of the drug in the intestine.
• With estrogen-containing drugs, it is necessary to increase the dosage of levothyroxine sodium because of the increase in thyroxine-binding globulin. And when interacting with somatotropin, the closing of epiphyseal growth zones is accelerated.
• When used with phenobarbital or rifampicin, the rate of elimination of levothyroxine sodium is increased, so an increase in the dose of Bagotirox is required.

[3], [4], [5]

Storage conditions

The storage conditions of Bagotyrox are described in the drug's instructions and must be followed. The drug should be stored in a dry, protected from light and inaccessible to children. Storage temperature should not exceed 25 ° C.

Failure to comply with storage conditions leads to damage to the drug and the loss of its medicinal properties. In this case, the use of Bagotiroks should be discarded, since there may be symptoms of overdose and side effects.

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Special instructions

Bagothyrox is prescribed for patients with a decreased function of the thyroid gland and as a means for conducting substitution therapy for her diseases. The thyroid gland is an endocrine organ that accumulates and produces iodine-containing hormones. Diseases and lesions of the thyroid gland violate the regulation of the metabolism in the body. Bagotiroks allows to normalize hormone production and treats thyroid dysfunction.

Bagotyrox is a drug that helps cure thyroid diseases, and normalize the production of hormones. The drug is prescribed by a doctor with the choice of individual dosage and duration of treatment. Bagotiroks has a minimum of side effects, which makes it an effective drug for people with reduced functions and lesions of the thyroid.

Shelf life

The shelf life of Bagotirox is indicated on the package of the drug and is 24 months from the date of manufacture. After the expiry date, the drug must be disposed of. An overdue product should not be taken, as this will lead to uncontrolled side symptoms.

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