B-mox

B-mox (international name - Amoxicillin) is a drug of the penicillin group and belongs to the pharmacological group of systemic antibacterial drugs.

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Indications B-moxa

Indications for the use of the antibacterial drug B-mox include diseases caused by infectious agents: tonsillitis, bacterial pharyngitis, acute otitis, sinusitis, bronchitis, pneumonia, acute and chronic infectious diseases of the urinary tract (urethritis, pyelonephritis, etc.), infectious lesions of the skin and soft tissues, pathologies of the biliary tract and gastrointestinal tract of a microbial nature, as well as acute gonorrhea. B-mox is recommended for use in the complex therapy of chronic gastritis, gastric ulcer and duodenal ulcer, etiologically associated with the gram-negative bacterium Helicobacter pylori.

Release form

The release form of this drug: hard gelatin capsules of yellow color with a gray cap; 1 capsule contains 250 mg of amoxicillin and excipients (starch and talc).

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Pharmacodynamics

The active substance of the drug B-mox is a semi-synthetic antibiotic of the penicillin group amoxicillin. It has an active antimicrobial effect against gram-positive microorganisms (Staphylococcus spp. and strains that do not produce penicillinase, Streptococcus spp., etc.), gram-negative aerobes (Neisseria meningitidis, Neisseria gonorrhoeae, Proteus mirabilis, Escherichia coli), Helicobacter pylori, as well as Salmonella spp. and Shigella spp.

The drug slows down the production of the enzyme transpeptidase, which is a catalyst for the synthesis of the bacterial cell wall. Thus, the process of synthesis of the protein of the cell wall of microorganisms is disrupted, which leads to the cessation of their development and the destruction of the cells of pathogenic microbes.

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Pharmacokinetics

After internal administration of the drug B-mox, more than 90% of the active substance is quickly absorbed in the gastrointestinal tract and distributed throughout the tissues and body fluids. After 1-2 hours, the maximum concentration of amoxicillin in the blood plasma is reached; 20% of the antibiotic binds to plasma proteins.

The half-life of the drug is 60-70 minutes. Almost 60% of the dose taken, mostly unchanged, is excreted from the body in the urine (within 8 hours); some is excreted through the gastrointestinal tract and lungs. In case of kidney dysfunction, the rate of purification of the body from metabolites decreases, which increases the concentration of the drug in the blood plasma.

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Dosing and administration

The dosage of the drug and the duration of the course of treatment with B-mox are determined by the doctor individually, depending on the severity of the disease and the sensitivity of its pathogen to penicillins.

Adults and children over 10 years of age are prescribed 500 mg of amoxicillin every 8 hours, the daily dose is 1.5 g. In severe infections, the dose can be increased: 1 g three times a day - at 8-hour intervals. Treatment with B-mox involves taking the drug for 48-72 hours after the symptoms of the disease disappear. Special instructions apply to the appointment of B-mox in patients with severe renal failure. In such a situation, either the single dose of this drug is reduced, or the interval between its doses is increased (from 8 to 12 hours).

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Use B-moxa during pregnancy

B-mox penetrates the blood-brain barrier. The US Food and Drug Administration (FDA) fetal impact category is B (i.e. animal studies have not shown a risk to the fetus, and no human studies have been conducted).

The use of B-mox during pregnancy and breastfeeding is possible provided that the expected benefit to the pregnant woman and nursing mother outweighs the potential risk to the fetus or child.

Contraindications

Contraindications for the use of B-mox include individual sensitivity to the drug or its components and a history of allergy to cephalosporin and penicillin antibiotics. This drug is contraindicated in severe liver failure; in the treatment of infections caused by microorganisms insensitive to the drug (especially pseudomonads and staphylococci). B-mox is not prescribed for bronchial asthma, secondary infections in infectious mononucleosis, and lymphocytic leukemia. It is not recommended to prescribe the drug in capsule form to children under 10 years of age.

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Side effects B-moxa

During the administration of the drug B-mox, allergic reactions in the form of exanthema, urticaria and itching, as well as immediate systemic allergic reactions may occur. From the digestive system, such manifestations as nausea, vomiting and diarrhea are possible.

In rare cases, in patients with reduced body resistance and chronic diseases, superinfection may develop during treatment with B-mox.

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Overdose

B-mox does not cause specific symptoms, although more intense manifestation of side effects of this drug is possible. In case of exceeding the recommended doses, gastric lavage is performed and oral administration of activated carbon is prescribed.

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Interactions with other drugs

B-mox, like other drugs containing amoxicillin, is not prescribed together with antimicrobial drugs that act bacteriostatically (macrolides, lincosamides, tetracyclines, sulfonamides). The simultaneous use of B-mox and the antipodagric drug allopurinol increases the likelihood of skin rash. And simultaneous use with antacids (drugs that neutralize hydrochloric acid in gastric juice) reduces the absorption of amoxicillin and its therapeutic effect.

The interaction of B-mox with indirect anticoagulants (with such antithrombotic drugs as warfarin, dicoumarol, phenylin) increases their effectiveness - by suppressing intestinal microflora and reducing the production of vitamin K. B-mox is also capable of significantly reducing the effect of hormonal oral contraceptives.

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Storage conditions

Storage conditions: dry, dark place, optimal storage temperature: +18-25°С.

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Shelf life

The shelf life of the drug is 24 months.