B-insulin S.S. Berlin-Chemie

B-insulin S.C. Berlin-Chemie is an insulin with an intermediate period of action.

There are several forms of insulin that are used to treat diabetes. B-insulin S.C. Berlin-Chemie is pork insulin. The medication normalizes blood glucose levels.

If you have been diagnosed with prediabetes, you can manage your condition by simply making lifestyle changes, increasing physical activity, eating a healthy diet, eating low-calorie foods, and focusing on fruits and vegetables.

Oral medications control glucose in people whose pancreas still produces the hormone.

However, if your doctor decides that hormone therapy is necessary, you will need to choose a treatment that suits your lifestyle, age, and other factors.

Medicine uses human and porcine hormones. Human hormones have been used in medicine for only 20 years. They have their drawbacks: patients experience weight gain and increased appetite. Human hormones are cheaper than porcine hormones. Injections are safe and painless. In 1978, scientists managed to “force” E. coli to produce human insulin. In 1982, Americans began selling it. Unfortunately, the domestic industry does not produce human hormones.

However, over the last 10 years, world pharmacology has been puzzled by the search for an analogue of human and porcine insulin. Such insulins are already appearing and are being introduced into medical practice. Their injections are painless and safe. Insulin analogues begin to “unfold” in the blood faster and do not cause allergies.

However, I would like to dwell on the medium-acting porcine insulin S.C. Berlin-Chemie.

B-insulin S.C. Berlin-Chemie is the drug of choice in the treatment of diabetes, both in combination with antidiabetic tablets and short insulins, and in isolation.

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Indications B-insulin S.S. Berlin-Chemie

Indications for use of the medication are as follows: diabetes mellitus type I, diabetes mellitus type II.

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Release form

The drug is available in the form of an injection solution of 40 U/m.

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Pharmacodynamics

The pharmacodynamics of the drug are as follows: the drug reduces blood glucose in those who suffer from diabetes. After binding to the cell membrane, B-insulin promotes glucose to enter the cell and be utilized. The liver increases glycogen synthesis as a result of taking the drug. The body stores glucose in the form of glycogen.

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Pharmacokinetics

B-insulin S.S. Berlin-Chemie is a prolonged insulin. Hormone crystals enter the body after injection in the form of amorphous particles. A reaction occurs between insulin particles placed in an environment with an acidic pH and a neutral environment of body tissues. It takes 3 to 8 hours for the drug to take effect. The effect of taking the drug is observed for 16 hours. The higher the dose of insulin administered, the longer it acts. A low dose is absorbed by the body quickly, but its duration of action is shorter than that of a high dose of the drug. Be careful: the drug is not administered intravenously!

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Dosing and administration

The drug is administered subcutaneously with a small insulin syringe, 45 minutes before meals. Doses are individual. The approximate dose for adults is 0.3–0.8 U/kg/day in 2 doses (2/3–3/4 doses before breakfast and the remainder before dinner) or 1 time (when combined with other antidiabetic drugs in tablet form), for juvenile diabetes (in combination with short insulins).

Lower doses may be used in children, but in general the dosage for them is not much different. When conducting combined therapy with prolonged-action insulin and short-acting insulin, the B-Insulin SC Berlin-Chemie portion is about 75-80%.

Use B-insulin S.S. Berlin-Chemie during pregnancy

Use of the drug during pregnancy is permitted. Patients on insulin during pregnancy need to monitor their metabolism more carefully than usual, and be sure to tell their doctor about their pregnancy. Pregnant diabetics need special pregnancy management tactics and may even be hospitalized.

If the need for the hormone decreases in the first trimester, then starting from the second trimester, the body's need for it is expected to increase. After the birth of the child, hypoglycemia may occur, the need for the hormone drops sharply.
During breastfeeding, the required insulin dose may change. There are no restrictions for taking B-insulin S.C. Berlin-Chemie during lactation.

Contraindications

Contraindications for the use of B-insulin: hypersensitivity, allergy to immediate-type insulin, which can develop into life-threatening conditions, anaphylactic shock, generalization.

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Side effects B-insulin S.S. Berlin-Chemie

Hypoglycemia is a decrease in blood glucose levels with profuse sweating. It is characterized by a decrease in blood sugar below 50 or 40 mg / dL (2.8 or 2.2 mmol / L), which can lead to loss of consciousness.

Causes of hypoglycemia:

1. Improved glucose tolerance (spontaneous, as a result of eating low-calorie foods).
2. Skipping meals, breaking your diet.
3. Muscle overload.
4. Hormone overdose.
5. Change of drug.
6. Interaction with alcohol.

Every patient should remember the symptoms of such a condition as hypoglycemia. Avoid risky situations.

Hyperglycemia. Diabetic coma occurs due to increased blood sugar levels (dietary errors, irregular insulin intake). Diabetic coma occurs slowly.

Symptoms of diabetic coma: thirst, loss of appetite, dry skin, rapid breathing, increased glucose and acetone in urine. Requires immediate medical attention.

Allergic reactions. Rarely, redness of the skin at the injection site may be observed. Severe redness with the formation of blisters, accompanied by itching and the formation of blisters are the first signs of an immediate type of allergy. If the drug is not changed, anaphylactic shock may begin. It requires hospitalization, emergency care.

Rarely, antibodies may form. Atrophy and necrosis may develop at the injection site.

Other side effects: Edema and obesity. These phenomena pass with time.

To choose the right insulin for diabetes therapy, you need to consult a therapist or endocrinologist. Usually, treatment always begins with prescribing human insulin before bedtime, the minimum dose of which is 10 IU.

However, if your blood sugar reaches 12 mmol or higher, you will be prescribed short-acting insulins.

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Overdose

Symptoms of insulin overdose: hunger, tachycardia, nervous excitability, pallor. The patient's forehead becomes covered in sweat. Headaches and behavioral disorders are possible. If hypoglycemia develops, you need to eat something sweet. If the condition is severe, you need to inject glucagon (0.5-1 mg) intravenously.

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Interactions with other drugs

Hypoglycemia is increased by alcohol, MAO inhibitors, tetracycline-based antibiotics, acetylsalicylic acid, and amphetamines. Hypoglycemia is alleviated by taking diuretics, hormonal contraceptives, heparin, lithium and nicotinic acid preparations, and glucocorticoids.

Some drugs, such as reserpine and salicylates, can either enhance or inhibit the action of insulin.

Some drugs can mask the symptoms of hypoglycemia, such as clonidine.

B-insulin is incompatible with alcohol intake.

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Storage conditions

Store at a temperature of 2 to 8 º C. Do not freeze the drug and keep it out of the reach of children. Insulin is best stored in the refrigerator, but it can also be stored indoors for a short time and so that it is not exposed to sunlight. When flying, keep insulin with you so that it does not freeze in the luggage compartment. Do not store the drug in places that are constantly heated.

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Special instructions

It is important to inject in a different place each time. Ask your doctor to teach you the injection technique.

Shelf life

The shelf life of the drug is 24 months.

After the first withdrawal from the bottle, the shelf life of the medicine is 3 weeks when stored in the refrigerator.

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