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Azogel
Last reviewed: 23.04.2024
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Indications of the azogel
It is used to eliminate various forms of common acne, and also in the treatment of rosacea papulo-pustular nature.
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Release form
The release is carried out in a helium form, in tubes with a volume of 15 or 30 g. In the package - 1 such tube.
Pharmacodynamics
Medication Azogel has a pronounced antimicrobial effect, which is due to the medicinal characteristics of nonanedioic acid, and in addition to direct influence on the process of hyperkeratosis of follicles.
The use of the gel can dramatically reduce the density of the colonies of propionibacteria acne, and in addition, reduce the amount of FFA fractions inside the skin lipids, thereby weakening cell growth, which leads to a decrease in the processes of occlusion and keratinization of skin pores. The action of nonanedioic acid promotes inhibition of keratinocyte multiplication, and at the same time improves epidermal differentiation in the occurrence of acne.
The medicine softens the skin, and besides it helps to quickly remove redness and prevent the development of local irritating effect in the skin area.
Pharmacokinetics
The gel applied on the skin passes into all its layers. It is necessary to take into account that the medication penetrates into the damaged skin of the skin faster. The level of systemic absorption is relatively low, equal to approximately 3.6% of the used dosage.
Metabolism is carried out inside the liver - by the β-oxidation of the active element to dicarboxylic acids, which have a shorter chain.
Excretion is done with urine - a part in the form of an unchanged component, and a part in the form of dicarboxylic acids.
Dosing and administration
Before the treatment of the skin surface, it is first necessary to perform the appropriate hygienic procedures - rinse it with clean water (or use a cleanser with a mild effect), then completely dry this area. Treat affected areas with a thin layer, twice a day, gently rubbing the gel into the skin.
If there is a strong irritation, the frequency of the procedures should be reduced to the 1 st time per day. If it is required, you can get rid of irritation by taking a break in the use of drugs, which is 2-3 days.
The duration of the course of therapy is determined individually, but under any conditions, it takes a long time to heal - at least 1 month.
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Use of the azogel during pregnancy
During pregnancy.
Appropriate, adequately controlled tests regarding the use of external drugs of nonanedioic acid in pregnant women have not been carried out.
Animal tests showed no direct or indirect adverse effects on the development of the fetus during pregnancy, and also on childbirth and development in the postnatal stage.
When pregnancy, use Asogel should be very cautious.
When breastfeeding.
Do not allow contacts of the newborn with the skin or breast that has been treated with gel.
There is no information as to whether azelaic acid passes into the mother's milk in vivo. But the in vitro test, which was performed using the dialysis equilibrium technique, showed that the active element is able to penetrate the mother's milk. Systemic absorption of nonanedioic acid (after local treatment) does not increase the endogenous effect of this component, comparable to normal physiological values.
But lactating women still need to carefully use this drug.
Contraindications
The main contraindication is hypersensitivity to the gel. In addition, acne should not be prescribed for children younger than 12 years of age, because there is no information on the efficacy and safety of use of drugs in this category of patients.
Side effects of the azogel
The use of the gel sometimes leads to the appearance of such side effects: a change in skin tone, puffiness, rashes, itching, severe dryness and peeling. In addition, there is also a development of erythema, paresthesias, folliculitis, skin irritation and hyperemia. There may be seborrhea, acne, cheilosis, contact form of dermatitis, hypochromia, and in addition exacerbation of the course of bronchial asthma.
Storage conditions
Asogel is required to be kept at temperature values within the limits of 5-15 ° C.
Shelf life
Azogel can be used for 2 years since the release of the drug.
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Reviews
Azogel receives extremely polar feedback on the effectiveness of drug exposure. Some patients claim that the drug has a qualitative effect, but the other part is sure that the drug is completely useless and not worth the money spent on it.
For some patients, a noticeable effect began to appear after the expiration of a month of use, but there are also testimonials that even after 5 months of use no improvement was noted.
Attention!
To simplify the perception of information, this instruction for use of the drug "Azogel" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.