Azcine

Azcin has an antimicrobial effect.

Indications of the azcine

It is used to eliminate such violations:

• diseases in the area of the urogenital system;
• STDs;
• pathologies affecting the ENT system and respiratory organs (such as otitis, sinusitis, bronchitis with laryngitis, and in addition pharyngitis and pulmonary inflammation);
• diseases in the soft tissue (among them folliculitis, dermatitis of an infected nature, impetigo, wound lesions and erysipelas);
• tick-borne borreliosis;
• destruction of the microbe Helicobacter pylori.

Release form

The release takes place in capsules, in a quantity of 6 pieces inside the blister pack. In the box - 1 blister with capsules.

Pharmacodynamics

The active element of the drug is azithromycin - a semi-synthetic component, a representative of the category of macrolide antibiotics. Has high acid resistance in comparison with other macrolides. Has a bacteriostatic effect, but with respect to individual strains demonstrates bactericidal effect. Azithromycin slows down protein binding inside microbial cells, thereby suppressing their reproduction.

The bacteriostatic effect develops in relation to gram-positive and also gram-negative aerobes (among which also those that produce β-lactamases).

The stability with respect to the active element is possessed by enterobacteria, pseudomonas and acinetobacter. In addition, the drug has no effect on bacteria that have resistance to erythromycin.

Pharmacokinetics

After oral administration, it is well absorbed inside the digestive tract. Admission together with food reduces the intake and bioavailability. It does not undergo changes under the influence of acidic gastric environment. Peak values inside the plasma are recorded after a lapse of 2-3 hours.

The index of protein synthesis is up to 50%. The highest concentrations of the active element are noted inside the middle ear exudate, tonsils, and in addition mucous respiratory tract and urogenital system. The medicine can accumulate inside the lysosomes, and then it is released by phagocytosis. Metabolic processes are carried out in the liver.

Excretion occurs with bile. About 6% of the substance is excreted in the urine. The half-life is 35-50 hours, and in some patients it reaches 80 hours.

Dosing and administration

To be used orally, on an empty stomach (120 minutes after eating or 60 minutes before). It is necessary to swallow the capsule whole, and then to drink it with water. The sizes of portions are prescribed by the doctor, guided by the patient's condition.

To eliminate pathologies in the respiratory tract, and in addition, the ENT system should take 0.5 grams of medication once a day for 3 days.

In the treatment of skin infections, 0.5 g of Azicine is used on the first day of the course, and then 0.25 g once a day is required. On average, therapy lasts for 5 days.

For the treatment of STDs, a one-time dose of 1 g of medication is needed.

When eliminating ulcers, combined with Helicobacter pylori, it is necessary to drink 1 gm LS per day for 3 days.

During therapy for tick-borne borreliosis, 1 g of the drug is consumed on the first day, and then for another 4 days, 0.5 g daily. For the entire course you need to take 3 grams of Azitine.

[1]

Use of the azcine during pregnancy

Use of Azicine during pregnancy is prohibited.

Contraindications

The main contraindications:

• the presence of intolerance against macrolide drugs;
• children under 3 years of age;
• expressed stages of disorders of hepatic activity;
• children weighing less than 25 kg;
• lactation period.

Caution is required when administering to persons with severe kidney failure.

Side effects of the azcine

Use of the drug may cause the development of the following side effects:

• dizziness and headaches, insomnia and a feeling of intense excitability, and in addition tremor in the limbs and tachycardia;
• epigastric pain, deterioration of appetite, nausea, stool disorders, bloating, vomiting, and in addition an increase in the activity of hepatic transaminases;
• eosinophilia or neutropenia;
• rashes, hives, and itching;
• nephritis or vaginitis;
• Candidomycosis in the oral mucosa.

Overdose

Intoxication develops in the form of stomach pains, vomiting, diarrhea and nausea. Headaches, hearing disorders and cholestatic hepatitis can also occur.

Does not have a special antidote. Gastric lavage, sorbent intake, as well as symptomatic procedures are performed. If severe intoxication is noted, it is necessary to perform extracorporeal hemosorption.

Interactions with other drugs

Combined use with antacids inhibits the absorption of azithromycin, which is why it is necessary to dilute the use of drug data in time (minimum 2-hour interval).

Azitine does not affect the efficacy and pharmacokinetic parameters of drugs metabolized by the hemoprotein P450 system (such as midazolam, theophylline with digoxin, and ergot alkaloids and bromocriptine).

[2], [3]

Storage conditions

Azithine should be kept in standard for medicines conditions. The temperature is not higher than 25 ° C.

[4]

Shelf life

Azithine is allowed to be used for 2 years from the date of manufacture of the drug.

Reviews

Azitin selectively cumulates inside infected tissues with the registration of drug-effective concentrations. Such a unique orientation towards tissues allows one to use the medicine once a day and apply it to short-term courses. Experts believe that such a dosing scheme has high performance indicators.

The use of drugs is very helpful in treating genitourinary infections, which are not eliminated with cephalosporins and penicillins.

Possessing an optimal ratio of price and quality, as well as a convenient mode of use and a variety of release forms, the drug is very popular among patients, which they note in their reviews.

It should also pay attention to the high level of its safety - negative manifestations are rare, and there is no special interaction with other drugs. Important is also the fact that due to the short-term use the medicine does not affect the microflora of the mouth and intestines.