Aviomarin

Aviomarin is used when it is necessary to prevent or cure nausea and vomiting (seasickness, airsickness, radiation therapy, Meniere's syndrome).

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Indications Aviomarina

Aviomarin is used when it is necessary to prevent or cure nausea, vomiting (seasickness, airsickness, radiation therapy, Meniere's syndrome), in addition, when treating nausea, dizziness, if a person has labyrinthine disorders of various origins, it is also used for the prevention of all the above diseases.

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Release form

The drug Aviomarin is available in the form of tablets 50 mg.

Pharmacodynamics

Dimenhydrinate is classified as a histamine H1 receptor blocker (ethanolamine group). In addition to the antihistamine effect, drugs of this group are characterized by the provision of antiemetic, sedative and M-anticholinergic effects.

Dimenhydrinate has an antiemetic effect, which is based on the suppression of the vomiting centers. It is enhanced by the M-cholinolytic effect, when the tone of smooth muscles and peristalsis in the gastrointestinal tract decreases, the salivary glands and stomach weaken their secretion.

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Pharmacokinetics

Oral use of dimenhydrinate promotes its rapid absorption. Half an hour after use, its concentration in the blood plasma reaches its maximum, and it lasts for three to six hours.

Blood plasma proteins form a bond with dimenhydrinate (98 - 99%). The liver biotransforms Aviomarin, then it is completely eliminated from the body by the kidneys within 24 hours. Three and a half hours is the half-life of Aviomarin from the body.

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Dosing and administration

• Prevention:

When Aviomarin is used for preventive purposes, it is taken 30 minutes before the trip begins. Also half an hour before anesthesia and if drugs that are difficult for the body to tolerate are used.

Adults and children over fourteen years of age take 50-100 mg (one or two tablets of Aviomarin) every four to six hours for prevention. The maximum daily dose is eight tablets (400 mg).

Children aged five to fourteen years for prophylaxis take 25-50 mg (half to one tablet of Aviomarin) every six to eight hours, if necessary, but no more than 150 mg per day.

For children aged two to five years, the recommended dose for prophylaxis is 25-50 mg (half to one tablet of Aviomarin) every six to eight hours, but the maximum daily dose should not exceed 75 mg.

If necessary, the dose is repeated six to eight hours after the last use of Aviomarin.

• In treatment:

For adults and adolescents (over fourteen years of age), the recommended dose for treatment is 50-100 mg, if necessary, every four hours; the maximum daily dose should not exceed 400 mg.

For children aged five to fourteen years, the recommended dose for treatment is 25-50 mg, if necessary, at intervals of six to eight hours; the maximum daily dose should not exceed 150 mg.

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Use Aviomarina during pregnancy

Aviomarin is contraindicated in the first trimester of pregnancy. It is used with extreme caution when the first trimester of pregnancy is already over, as well as during lactation. And still, Aviomarin is used only when there is an extreme need for it. During the labor period, dimenhydrinate in some cases leads to hyperstimulation of the uterus and bradycardia that threatens the child.

Contraindications

Contraindications to the use of Aviomarin are the presence of:

• hypersensitivity to the components of Aviomarin (especially attention to dimenhydrinate);
• eclampsia, epilepsy;
• acute exudative and vesicular dermatoses;
• renal failure;
• first trimester of pregnancy;
• children under two years of age.

Side effects Aviomarina

Side effects of Aviomarin are:

• weakness;
• fatigue;
• drowsy state;
• difficulty concentrating;
• anxiety;
• nausea;
• gagging;
• diarrhea;
• constipation;
• feeling of dryness of the oral mucosa;

In rare cases, Aviomarin impairs vision (weakening of night vision and color perception), and in some cases, hemolytic anemia, dizziness, decreased blood pressure, insomnia, and dysuria have been reported.

Overdose

When a significant overdose of Aviomarin occurs, the following symptoms are observed: breathing slows down, convulsions, psychosis with hallucinations, delirium, drowsiness, dizziness are observed, to the point that a person can fall into a coma.

There is no specific antidote for Aviomarin. To remove the clinical manifestations of overdose, the stomach is usually washed, enterosorbents and saline laxatives are prescribed.

Interactions with other drugs

If Aviomarin interacts with sleeping pills, sedatives, tranquilizers, antidepressants, antipsychotics (neuroleptics), antiepileptic drugs and alcohol, the suppressive effect of these drugs on the human central nervous system is enhanced.

When using Aviomarin, the anticholinergic effect of other drugs may be enhanced. Ototoxic agents (for example, aminoglycosides) in interaction with Aviomarin may hide the presence of their side effects.

When Aviomarin is used with bismuth, scopolamine, and painkillers and psychotropic drugs, the patient's vision may deteriorate.

Aviomarin and ototoxic antibiotics are incompatible: it is better not to use it simultaneously with streptomycin, neomycin, kanamycin, amikacin. The fact is that the presence of the main active component - dimenhydrinate - can mask hearing damage.

Corticosteroids, anticoagulants, and apomorphine weaken their effect when combined with Aviomarin.

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Storage conditions

The temperature at which Aviomarin is stored should be 15–25˚C. The place should be protected from exposure to light rays and light in general, and also inaccessible to children.

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Shelf life

The shelf life of Aviomarin is four years.