Avandia

Diabetes mellitus is a serious problem in the modern world. His treatment is highly dependent on the characteristics of the body and the tolerability of certain substances and ingredients of medicines. And yet there is a drug that managed to prove itself well in the treatment of diabetes - Avandia.

[1], [2], [3]

Indications Avandia

Avandia is used to treat type 2 diabetes. Application is prescribed as a monotherapy, in case a person lacks physical exertion and diet therapy. In some cases, it is used with metformin and insulin to improve glycemic control.

Release form

Avandia is a medical preparation containing rosiglitazone. Tablets are pentagonal in shape and covered with an orange coating. Produced in blisters for 7 and 14 pcs., With rosiglitazona content of 4 and 8 mg / tab.

Pharmacodynamics

Avandia is an oral agent and belongs to the group of thiazolidinediones. The main component of the drug - rosiglitazone - lowers the level of glucose in the blood and improves the body's response to insulin. Also, the drug improves metabolic processes in the body and reduces the level of fatty acids in the blood. Rosiglitazone has a positive effect on the function of β-cells, which contributes to an increase in the mass of the islets of Langerhans in the pancreas and increases the insulin content. The drug positively affects the secretion of the pancreas, preventing excessive production of insulin. All this leads the body to normal and promotes recovery from diabetes.

[4], [5], [6], [7], [8], [9], [10]

Pharmacokinetics

After the tablet rosiglitazona gets inside the body, after an hour, useful substances begin their work to improve the blood condition. Admission of the drug after meals significantly increases the time of splitting rosiglitazona in the body. Accordingly, I recommend taking Avandia on an empty stomach. In the human body rosiglitazone undergoes intensive metabolism by N-demethylation. Substances of the drug 3-4 hours after the administration are excreted from the body in the form of metabolites through the bladder or in the form of callous feces. Accordingly, prescribe the drug to people suffering from impaired renal function, should only after a thorough examination and the delivery of appropriate tests.

[11], [12], [13], [14], [15], [16]

Dosing and administration

Indications for dosage are appointed exclusively individually. As a rule, the daily norm of the drug is used in 1-2 approaches. For adults, the daily intake of the drug is 4 mg. If the result is not, then to improve the effectiveness of treatment after 6-8 weeks, the daily rate should be increased to 8 mg / day on the recommendation of the doctor. For patients over the age of 45 years, changes in dosage are not used.

[21], [22], [23], [24]

Use Avandia during pregnancy

Do not take Avandia during pregnancy.

Contraindications

The drug Avandia is contraindicated for use by children under 18 years of age, people with impaired functionality of the kidneys and liver, as well as women in the position during lactation. It is also not recommended to use Avandia for type 1 diabetes mellitus. However, when applying the medicine Avandia, on the recommendation of the attending physician, side effects are possible.

Children this drug is absolutely contraindicated.

[17], [18]

Side effects Avandia

In order to avoid side effects of the drug, you should carefully follow the recommendations of the treating specialists and monitor the dosage of the drug. And, of course, do not apply Avandia in cases of disruption of the kidneys and liver.

[19], [20]

Overdose

Thus, with the use of the drug, there may be edemas or hypercholesterolemia. This will indicate the occurrence of side effects in the metabolic system. There is also an increase in the activity of hepatic enzymes, peripheral edema, in rare cases - anemia.

Interactions with other drugs

Avandia has no special complications in the case of use with other medicinal products. Although taking the drug together with derivatives of sulfonylureas is not recommended, as in patients with type 2 diabetes it can cause synergism of hypoglycemic action.

[25], [26], [27]

Storage conditions

Keep medical product Avandia should be out of reach of children at a temperature of no more than 25 ^◦.

Shelf life

Shelf life of the drug is 2 years.