Antibacterial suppositories: application in urology and gynecology

In modern pharmacology, you can find a huge number of a variety of drugs that are released in the form of candles. Antibacterial suppositories are widely used in gynecology, urology and proctology, because, due to their special form, they easily penetrate the inflammation focus and eliminate it.

[1], [2], [3], [4], [5], [6], [7], [8]

Indications for use

When can a doctor prescribe antibacterial suppositories for you?

1. To protect the mucous membrane of the vagina from infections.
2. If the patient feels constant itching, burning in the vagina for no apparent reason.
3. With a broken menstrual cycle.
4. With inflammation of the urogenital system (adnexitis, oophoritis, salpingitis, colpitis, vaginitis).
5. In violation of the genital function of women.

The list of antibacterial candles that are used in gynecology is quite large. These drugs are usually divided, depending on the diseases with which they help to fight. Typically, such drugs are used to treat uterine fibroids, thrush, cysts, erosion, cystitis, bacterial vaginosis, colpitis, parametritis, endometritis and other diseases.

Pharmacodynamics and pharmacokinetics

Consider the pharmacodynamics of antibacterial suppositories on the example of the popular drug "Terzhinan".

This is a combined remedy, which is often used in gynecology for the treatment of many diseases. It differs anti-inflammatory, antimicrobial, antifungal, antiprotozoal and antibacterial action. The composition of the drug includes such components: ternidazole, neomycin, prednisolone and nystatin.

Ternidazole is a popular antifungal agent that helps reduce the synthesis of ergosterol in the cells of pathogenic fungi. This changes the structure of the membrane cell. It is active against gardnerell.

Neomycin is a popular antibiotic that is active against Gram-negative (Shigella dysenteriae, Escherichia coli, Shigella boydii, Shigella flexneri) and Gram-positive bacteria (Streptococcus pneumoniae, Staphylococcus).

Prednisolone is a substance with anti-inflammatory and anti-allergic effect.

Nystanine is an antifungal component of the drug that shows activity against yeast-like fungi (the genus Candida).

Pharmacokinetics of the drug "Terzhinan" has not been studied.

Names of antibacterial candles

Among the most popular antibacterial suppositories are the following drugs.

Lactonorm. This remedy is a new vaginal probiotic that helps deliver the necessary lactobacilli to the vagina. These suppositories are used to treat vaginal dysbiosis, vaginitis, vulvitis, bacterial vaginosis. Also with their help, it is possible to prevent dysbiosis in the vagina and urogenital tract during antibacterial treatment.

Lactonorm contains a large number of live acidophilic bacteria (at least 100 million CFU Lactobacillus acidophilus in 1 suppository) that help restore the vaginal microflora after prolonged use of antibiotics, after inflammation and hormonal failure.

In treatment, one vaginal capsule is prescribed twice a day (morning and evening) for seven days. For the prevention of therapy can continue for two weeks.

Phytoraxin. This drug has proven itself in the complex therapy of uterine myomas, colpitis, cervical erosion. The agent contains components of plant origin (propolis, celandine), potassium iodide and a polyphenolic complex of gallic acid. Phytoraxin does not affect healthy cells, but it inhibits the growth of cancer.

It is applied twice a day for one suppository rectally or vaginally (depending on the disease). Do not use if intolerance to the components of the drug. There were no side effects.

Terzhinan. This drug is antiprotozoal, antibacterial, anti-inflammatory, antifungal. Actively used in gynecology in the treatment of many gynecological diseases (colpitis, candidiasis and bacterial vaginitis, trichomoniasis), as well as for their prevention.

The active ingredient is ternidazole. Also in the drug include: nystatin, neomycin sulfate, prednisolone sodium metasulfobenzoate. Suppositories are administered vaginally one suppository once a day (best before bedtime). Before use, it is recommended to hold the tablet under water for twenty seconds. To introduce a prone. Therapy lasts about ten days on average. Prophylaxis is six days.

Do not use the drug with intolerance to its components. Among the main side effects are: burning and itching in the vagina after injection, allergy.

Methyluracil. The active ingredient is methyluracil. This drug is often prescribed for the treatment of bacterial cystitis, proctitis or sigmoiditis.

It is administered rectally for 1 tablet three to four times a day. Therapy can be quite long (from seven days to four months).

The drug is contraindicated with intolerance of its main component. Sometimes it can cause such side effects as allergies, headache.

Antibacterial vaginal suppositories

Today, with any disease of the genital organs, women gynecologists prescribe antibacterial vaginal suppositories. They are of particular importance in the treatment of inflammatory processes. It is the suppositories or suppository that are considered today as a unique form by which the drug substance can be effectively delivered to the inflammatory focus, while minimizing the side effects.

Colpitis causes inflammation of the vaginal mucosa. Colpitis is of different types, but the suppository is prescribed only for the treatment of nonspecific colpitis. As a rule, at the same time antibacterial drugs are used, which include a broad spectrum antiseptic. The most popular means for nonspecific colpitis are:

1. Terzhinan. Active active substance ternidazole. Dosage: one tablet once a day for ten days.
2. Polizhinaks. Active active ingredients nystanine, neomycin and polymyxin B. Dosage: one tablet twice a day for five to fourteen days.
3. Betadine. Active ingredient is iodine. It is administered twice a day for six to twelve days.

If colpitis was caused by Trichomonas, the best agents are the suppository based on metronidazole:

1. Clione D. It is introduced once a day for ten days.

2. Ginalg. It is prescribed for ten days for one tablet per day.

In genital herpes, antiviral drugs in the form of suppositories are often used. Among them are particularly distinguished:

1. Viferon. It is administered rectally twice a day for five to seven days. The active ingredient is interferon.

In candida colpitis the most popular suppositories are:

1. Bifikol. The composition of the drug is dried bifidobacteria. Introduced vaginally once a day for ten days.
2. Atzilact. The composition contains live lactobacilli. Assign one suppository for ten days.

[12], [13], [14]

Antibacterial anti-inflammatory candles

As a rule, inflammatory processes in the vagina and reproductive organs of women are caused by various microorganisms (chlamydia, gonorrhea). The most frequent symptoms of inflammation are: cutting or aching pain in the right or left side of the groin.

In this case, suppositories are used, which can be administered both vaginally and rectally. The most popular drugs are:

1. Movalis. Rectal suppository with active active ingredient meloxicam. It is a non-steroidal anti-inflammatory drug. Dosage is appointed by the attending physician and is strictly individual. The drug is not taken with intolerance of its main component, severe cardiac and hepatic insufficiency, during pregnancy. Reception of suppositories can cause anemia, headaches, increased blood pressure.
2. Longitude. Active active ingredient is longidase. Used to treat prostatitis, cystitis, for the prevention of scarring after surgery. The drug is known for helping to get rid of adhesions. Entered rectally or intravaginally one tablet (best before bedtime) for ten to twenty days. The drug is contraindicated in malignant tumors, during pregnancy, children under twelve years of age. The main side effects are allergic reactions (itching, burning).

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Antibacterial rectal suppositories

As a rule, antibacterial rectal suppositories are prescribed for the treatment of chronic hemorrhoids and infections in female reproductive organs. In the treatment of hemorrhoids, suppositories help to heal faster in the anus, and also improve the regeneration of damaged tissues. The most popular rectal suppositories to date are the following.

Ultraproject. Active active substance of the drug is fluocortorone, which is a glucocorticosteroid. It helps to reduce the permeability of the walls of blood vessels, which reduces swelling of the tissues, itching and burning. Suppositories are used for trauma in the anus and hemorrhoids.

Suppositories are introduced immediately after defecation and thorough hygiene of the anal passage. Use one suppository per day until the complete disappearance of unpleasant symptoms.

The drug is contraindicated in chicken pox or other viral diseases, tuberculosis and syphilis in the affected area, during pregnancy and with intolerance of its components. The most common side effects are: itching, burning, allergies.

Posterizan. Means for the treatment of inflammatory diseases of the anorectal region (hemorrhoids, anal fissures, anogenital itching). Active active ingredients of the drug are: hydrocortisone, inactivated E. Coli cells.

Suppositories are administered in the early morning hours, as well as late at night (before bedtime). Also, in some cases, it is possible to administer each time after emptying. After the main symptoms of the disease have passed, the treatment is spent a few more days to fix the result.

Suppositories Posterizan can be used without fear, even during pregnancy. The only contraindication is the intolerance of the components. Among the side effects of using the drug are: allergies in the form of dermatological reactions.

[16], [17], [18]

Antibacterial suppository for prostatitis

For the treatment of prostatitis, special rectal suppositories are often used today. But it is worth noting that therapy can last for a long time, since there is an intestinal wall and a capsule of the prostate between the rectum and the prostate. For the treatment of prostatitis use suppository with antibiotics and antispasmodics, as well as with natural components, such as propolis.

The most popular suppositories from prostatitis are:

1. Rifampicin. Active active ingredient of the drug is the antibiotic rifampicin. It has a bactericidal effect against staphylococci, streptococci, clostridia, neisery, brucella, rickettsia, chlamydia, improves tissue regeneration. Suppositories are administered rectally one per day (best before bedtime), until the main symptoms of the disease disappear. The drug is contraindicated in case of intolerance of the main substance, in childhood, during pregnancy. May cause such side effects: worsening of appetite, pain in the abdomen, headache, blurred vision, inflammatory processes in the kidneys.
2. Simpletons. Active active ingredients of the drug are: royal jelly, flower pollen, honey, propolis and perg. It features wound healing and anti-inflammatory action. It is also used in the therapy of anal fissures and hemorrhoids. One suppository is used once a day for fifteen to thirty days. Before the introduction, the rectum must be emptied. Do not use if candle components are intolerant.

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Antibacterial suppository for cystitis

The most popular antibacterial candles that help cure cystitis are:

1. Hexicon. The active ingredient is chlorhexidine, active against treponem, chlamydia, ureaplasma, gonorrhea, gardnerella, trichomonads and herpes simplex virus types 1 and 2. It is usually used at the initial stage of cystitis or for its prevention.

Vaginally administered one suppository two times a day for five to fourteen days. For prevention, one suppository is used once a day for eight days. The only contraindication for this drug is the intolerance of its components.

2. Betadine. Active active ingredient is povidone-iodine. Additionally, the composition of suppositories includes macrogol. It is active against staphylococcus, fungi and E. Coli. Suppositories help not only cope with the main symptoms of cystitis, but also normalize the microflora of the vagina, save the woman from unpleasant burning and itching.

The drug is contraindicated when using other drugs with iodine, kidney disease, childhood, during pregnancy and breastfeeding. When used, side effects are possible: a sense of metallic bite in the mouth, a reaction on the skin, irritation of the eyes, and pain in the mouth.

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Method of using antibacterial candles

Antibacterial suppository is divided according to the method of their introduction: vaginal (injected directly into the vagina and suitable for the therapy of inflammatory processes in it), rectal (they enter the rectum through the anus).

Use of antibacterial suppositories during pregnancy

Most antibacterial candles, like other medicines, are contraindicated for use during pregnancy. Only in some cases, the attending physician can prescribe suppositories to pregnant women. Some drugs (Terzhinan, Betadin, Prosterizan) are completely safe for the health of the pregnant woman and the fetus.

Contraindications for use

Before using antibacterial rectal or vaginal suppositories, you should carefully study the instructions to find out when they are contraindicated for use.

As a rule, such drugs have only one contraindication: intolerance of their main active components. But in some cases (Betadin, Rifampicin, Ultraproject), there are other contraindications (tuberculosis or syphilis of the rectum, kidney disease, childhood, pregnancy).

[9], [10], [11],

Side effects

Among the main side effects from the use of antibacterial suppositories can be identified various allergic reactions (including on the skin), burning, itching. Also, in some cases, headaches, anemia, an unpleasant aftertaste in the mouth, and pain in the abdomen are possible.

Overdose

Cases of overdose with antibacterial suppositories were not revealed, since the necessary dose of substances was carefully calculated in one suppository.

Storage conditions and shelf life

All suppositories with antibacterial effect should be stored in a place protected from small children at a low air temperature (+25 degrees). Shelf life is usually two to three years. Do not use drugs after the expiration date.