Alomid

Alomid is a medication used in ophthalmology. It has antiallergic and anti-edematous properties. Contains the component lodoxamide.

Lodoxamide stabilizes the walls of mast cells and, at the same time, has the ability to suppress immediate manifestations of intolerance, which was discovered during extensive in vivo testing involving humans and animals. The substance helps to strengthen the strength of superficial vessels, preventing the impact that reagin or reactions caused by the activity of antigens and IgE have on them. [ 1 ]

Indications Alomid

It is used for non-infectious forms of allergic conjunctivitis:

• keratoconjunctivitis or vernal conjunctivitis;
• giant papillary conjunctivitis;
• spring form of keratitis;
• atopic form of conjunctivitis of allergic origin.

Lodoxamide has a therapeutic effect in the treatment of other eye diseases in which the main inflammatory stimulus is immediate symptoms of intolerance (labrocyte reaction).

Release form

The medicinal substance is released in the form of eye drops - inside Drop-Tainer type dropper bottles with a volume of 5 ml.

Pharmacodynamics

In vitro tests have shown that lodoxamide can stabilize mast cells in rodents and prevent antigen-induced histamine release. At the same time, the substance prevents the release of other inflammatory agents through mast cells (including PRS-A, anaphylactic substances with a slow reaction type, also called peptide leukotrienes) and inhibits eosinophilic chemotaxis.

The drug inhibits histamine release in vitro by preventing calcium ions from entering labrocytes after stimulation by an antigen. [ 2 ]

Alomid does not suppress COX activity and does not have antihistamine, vasoconstrictor or other anti-inflammatory effects.

Long-term use of the drug (periods lasting 0.5-2 years) did not cause the development of tachyphylaxis symptoms.

Pharmacokinetics

When using the drug in a dose of 1 drop inside each eye 4 times a day for a period of 10 days, plasma lodoxamide values that can be measured were not achieved (the detection threshold is 2.5 ng/ml).

Dosing and administration

The medication is used for ophthalmological procedures. The dosage is 1-2 drops in the conjunctival sac of the infected eye, 4 times a day at equal intervals.

Relief of the symptoms of the disease when using the drug (reduction of itching, photophobia, discomfort, sensation of a foreign object, lacrimation, conjunctival redness, swelling/erythema, epithelial lesions, active eye pain, ptosis, eye discharge and limbic symptoms) usually occurs after a few days, but sometimes therapy can continue for up to 1 month. In case of positive dynamics of signs, therapy should be continued until the effect is consolidated.

If necessary, Alomid can be used in combination with GCS.

In case of instillation of the drug for conjunctivitis of allergic origin, discomfort may be observed at first, which will subside as the condition improves.

After performing the instillation, it is necessary to close the eyelids tightly or perform nasolacrimal occlusion. This will reduce the overall absorption of the ophthalmic agent and reduce the risk of developing systemic negative symptoms.

• Application for children

There is no information regarding the therapeutic effect and safety of Alomid in children under 2 years of age.

Use Alomid during pregnancy

There are no relevant tests for the use of the drug during pregnancy. Animal tests have not revealed any negative effects on reproductive function, pregnancy, embryonic/fetal and postnatal development, or childbirth. The drug should be prescribed to pregnant women with great caution.

There is no information regarding whether the drug is excreted in breast milk.

Contraindications

Contraindicated for use in cases of severe intolerance to lodoxamide or other components of the drug.

Side effects Alomid

Side effects of an ophthalmological nature:

• mostly transient discomfort (tingling and burning sensation) appears;
• quite often, lacrimation, dry eyes and itching, hyperemia, blurred vision, discharge, a sensation of a foreign object develop, and crystalline deposits appear;
• Occasionally, eye fatigue, ulceration or erosion affecting the cornea, eye pain, swelling and puffiness, and scaling of the eyelashes/eyelids are observed. In addition, chemosis, blepharitis, ocular fever, keratitis/keratopathy, epitheliopathy, allergy, a feeling of eyelid sticking, abrasion in the corneal area, and precipitates in the anterior chamber of the eye appear.

General negative manifestations:

• systemic disorders: cephalgia is often observed;
• nervous system disorders: drowsiness or dizziness are occasionally observed;
• problems with the functioning of the cardiovascular system: occasionally there is a feeling of heat;
• respiratory dysfunction: dryness of the nasal mucosa and sneezing occasionally appear;
• symptoms associated with the gastrointestinal tract: occasionally, stomach discomfort and nausea develop;
• Epidermal lesions: rashes occasionally occur.

Interactions with other drugs

When using the drug in combination with other local ophthalmic substances, it is necessary to observe a 10-15 minute interval between their administration.

Storage conditions

Alomid should be stored in places closed to small children. Temperature indicators are within the range of 15-27°C. The bottle with the medicine should be tightly closed.

Shelf life

Alomid can be used for a 24-month period from the date of manufacture of the medicinal product. The shelf life of an opened bottle is 1 month.

Analogues

Analogues of the drug are Lecrolin, Emadin with Alergokrom, Pallada, Opatadin and Cromoghexal with Opatanol.