Allochol

Allochol is a combined choleretic drug.

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Indications Allochol

Indications for use

• These tablets for abdominal pain are used for chronic hepatitis, cholangitis, cholecystitis.
• It is used for dyskinesia of the gallbladder and bile ducts, as well as for postcholecystectomy syndrome.
• Indicated for use in atonic constipation.

Release form

Allochol is produced in tablets, which are covered with a shell, which has a color from yellow-green to orange. The surface of the tablet is biconvex. If the tablet is broken across, then in the fracture a core is found, which is surrounded by two layers of shells.

One tablet contains the following active ingredients: condensed bile or dry bile - eighty milligrams, dried garlic powder - forty milligrams, nettle leaves - five milligrams, activated carbon - twenty-five milligrams. The excipients in the tablet include a certain amount of magnesium oxide, potato starch, aerosil, calcium stearate, sugar, povidone, basic magnesium carbonate, titanium dioxide, talc, tropaeolin O or tartrazan, beeswax, vaseline oil.

The tablets for stomach pain are placed ten pieces per blister pack. Five such packs are placed in a cardboard box, supplied with an instruction leaflet.

Pharmacodynamics

Allochol improves the secretory function of liver cells, which leads to a moderate choleretic effect. Allochol stimulates the production of bile acids, and also increases the osmotic gradient between bile and blood. All of the above increases the filtration of water and electrolytes into the bile capillaries. The drug also accelerates the flow of bile through the bile ducts, which helps prevent the spread of ascending infections and reduces the activity of inflammatory processes. Allochol has the ability to reduce the precipitation of cholesterol, which is the prevention of stone formation in the gallbladder. Dry bile improves the process of cholatoformation, namely, taurocholic and deoxycholic acids present in its composition. A larger amount of bile released into the intestinal lumen leads to a reflex increase in secretion and motor activity in the digestive system, and also improves the quality of fat emulsification and the entire digestive process. Dry garlic powder inhibits fermentation processes in the intestinal tract, which helps eliminate the symptoms of flatulence.

Pharmacokinetics

Allochol has the quality of good absorption in the intestinal section of the digestive system, which leads to the fastest inclusion of its active components in the processes of hepatic-duodenal circulation. The metabolism of cholic and chenodeoxycholic acid is carried out in the intestine. Chenodeoxycholic acid is also metabolized in the liver. In this organ, it is conjugated with various amino acids, secreted into bile, with which it again enters the intestinal section, where it is partially reabsorbed, the other part of the acid is removed from the body with feces.

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Dosing and administration

The medicine is used after meals. Adults are prescribed to take one or two Allochol tablets three or four times a day. The course of treatment is three to four weeks. If therapy needs to be continued, the medicine is taken one tablet two or three times a day for one or two months.

On the recommendation of a specialist, the course of treatment is repeated two or three times with a break in therapy, which lasts three months.

Use Allochol during pregnancy

There is no data on the safety of Allochol during pregnancy and lactation. Nettle leaves can cause a uterotonic effect. Therefore, the drug can be used in the above periods only for vital indications for a woman, when the benefit to the mother outweighs the risk of problems in the fetus or child, and under the supervision of a specialist.

Contraindications

• The presence of hypersensitivity to the substances of the drug.
• History of acute hepatitis, cholelithiasis, obstructive jaundice, acute or subacute liver dystrophy.
• The patient has a spasm of the sphincter of Oddi, acute pancreatitis, aggravated gastric ulcer and duodenal ulcer, acute enterocolitis.

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Side effects Allochol

• The appearance of diarrhea.
• The occurrence of allergic reactions in the form of reddening of the skin, rash, itching of the skin.
• If allergic reactions are observed, it is necessary to stop using Allochol and use desensitizing therapy.

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Overdose

An overdose is possible if Allochol is used in large quantities, exceeding those permitted by the instructions. Also, overdose symptoms may occur with prolonged use of doses of the drug that exceed the maximum daily dose.

In this case, signs of diarrhea, nausea, itching of the skin occur, and transaminases in the blood increase.

In this case, you need to stop taking Allochol and carry out symptomatic therapy.

There is no specific antidote to the drug.

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Interactions with other drugs

There is no description of any negative effects of Allochol when used simultaneously with other medications.

It is not recommended to use Allochol simultaneously with drugs containing aluminum, cholestyramine, and cholestipol, as this leads to decreased absorption and a decrease in the therapeutic effect.

The simultaneous use of Allochol and choleretics of synthetic or plant origin leads to an increase in the choleretic effect. Allochol can lead to an increase in the effect of laxative drugs. Allochol has a stimulating effect on fat-soluble vitamins, which are better absorbed into the intestine.

When taking Warfarin and consuming garlic, which is part of the medication, at the same time, there is a risk of increased bleeding time.

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Storage conditions

Allochol - the medicine should be kept in a place protected from moisture, light and access by children at a temperature not exceeding 25°C.

Shelf life

Allochol is stored for 4 years from the date of production.