Aktovegin

Actovegin contributes to the activation of metabolic processes within the tissues of the body, and in addition to these healing processes. Also helps to improve trophism.

[1], [2], [3], [4], [5]

Indications Actuverine

Tablets are used for the following disorders:

• combination therapy of metabolic and vascular disorders affecting the cerebral region ( dementia or stroke of an ischemic nature, TBI, and with it, cerebral circulatory failure);
• diabetic polyneuropathy;
• disorders affecting the work of the venous and arterial vessels, and with it complications that develop as a result of such disorders (angiopathy or ulcers that have a trophic character).

Injections, and in addition to this dropper with the use of drugs used for similar conditions and diseases.

Use of medication in the form of ointment:

• inflammations that develop on the mucous membranes and the epidermis, as well as wounds (due to cuts, burns, cracks, abrasions, etc.);
• ulcers of a weeping nature, having a varicose etiology, and so on;
• activation of tissue healing associated with burns;
• prevention of the development of bedsores or their treatment;
• prevention of symptoms on the epidermis caused by radiation exposure.

In such conditions, use and cream.

The gel, in addition to the above disorders, is also prescribed for the treatment of the epidermis before carrying out the processes of skin transplantation during therapy for burn disease.

Actovegin can be assigned to athletes - to increase efficiency.

Release form

The release of the drug is in the form of injection fluid - in glass ampoules with a capacity of 2 or 10 ml. Inside the pack contains 5 ampoules. It is also produced in the form of an intravenous fluid infusion - in bottles of 0.25 l.

Tablets are contained in glass bottles in the amount of 50 pieces.

The cream is available in tubes of 20 g.

20% gel for the eyes is contained in tubes having a volume of 5 g.

5% ointment is sold in tubes of 20 g.

Pharmacodynamics

The active element of the drug, hemoderivate, is formed using ultrafiltration and dialysis.

The influence of the drug increases the resistance of tissues against hypoxia, because it stimulates the consumption and utilization of oxygen. Along with this, the drug helps to activate energy metabolism and glucose consumption. As a result, the cellular energy resource increases.

Due to the increase in the amount of oxygen consumed, the plasma cell walls are stabilized in persons with ischemia, and with it the volume of formed lactates decreases.

The effect of Actovegin increases cellular glucose indicators, and in addition stimulates oxidative metabolic processes. As a result, the energy supply of the cell is activated. This process is confirmed by the increase in indicators of free energy transporters: amino acids with ADP and ATP, as well as phosphocreatine.

The drug shows a similar effect in the development of disorders of peripheral blood flow, as well as the appearance of complications arising from these disorders. It is noted its effectiveness in accelerating the processes of regeneration of wounds.

In persons with burns, trophic disorders and ulcers of different origin, the biochemical and morphological properties of granulation improve under the influence of drugs.

Due to the fact that the drug affects the utilization processes inside the body, along with the absorption of oxygen, and also demonstrates the insulin-like effect, contributing to the oxidation and movement of glucose, it is a significant participant in the treatment of diabetic polyneuropathy.

In diabetics during the therapy with Actovegin, restoration of impaired sensitivity occurs and the severity of symptoms caused by mental disorders is reduced.

Pharmacokinetics

With parenteral injections, drug exposure develops approximately after 0.5 hours or less. The maximum effect is recorded on average after 3 hours.

Dosing and administration

Drug use patterns in the form of injections.

The injection fluid is allowed to be administered intraarterially, intravenously or intramuscularly.

Taking into account the severity of the pathology, injections are performed in portions of 10-20 ml (intravenously), and later administered at a low speed, 5 ml of the substance is administered intravenously. The medicine in ampoules is required to be applied daily or in an amount several times a week.

Ampoules are used in disorders of cerebral blood supply and metabolism. First you need to enter in / in the method of 10 ml of the substance for 14 days. Later, in the period of 4 weeks, 5-10 ml of the drug are injected with a frequency of several times a week.

People with a stroke of ischemic nature require intravenous administration of 20-50 ml of the drug, which is pre-dissolved in an infusion fluid (0.2-0.3 l). Within 2-3 weeks the drug is applied daily or with a frequency of several times a week. The same scheme is used for therapy in persons with arterial angiopathy.

Persons with trophic ulcers or other sluggish ulcerative lesions, as well as burns, must be administered in / in the method of 10 ml of the drug (or 5 ml by the / m method). This portion, taking into account the severity of the lesion, is used one-time or several times a day. In addition, local treatment with Actovegin is performed.

For the treatment or prevention of the development of lesions of the epidermis under radiation exposure, the substance is used daily at a dosage of 5 ml (intravenously), during the intervals between being in the radiation zone.

Methods for the use of infusion fluid.

Infusions are performed intraarterially or intravenously. The size of the dosage is determined by the patient's condition and diagnosis. Often, 0.25 liters of a substance is used per day. Sometimes the initial portion of the 10% solution increases to 0.5 l. The treatment cycle may include 10–20 infusions.

Before infusion, it is necessary to ensure the complete integrity of the medicine bottle. The introduction should be done at a speed of about 2 ml / minute. During the procedure it is necessary to control that the substance does not penetrate into the extravascular tissues.

The mode of application of the tablet form of drugs.

Tablets are consumed before meals, without chewing, but swallowing and squeezed with plain water. Often, 1-2 tablets are consumed per day, 3 times. The therapeutic cycle usually lasts 1-1.5 months.

For people with polyneuropathy of a diabetic nature, the drug is first intravenously administered at a rate of 2000 mg for the 21st day, and then it is used in the form of tablets - in the amount of 2-3 pieces per day for 4-5 months.

Ways to use the gel.

Gel treatment is done locally - to cleanse ulcerative and wound lesions, and with it for further treatment. If there is radiation injury or burn on the epidermis, the preparation is applied with a thin layer. In the case of an ulcer, you need to apply a thick layer of the substance, and then close the treated area with a compress soaked in medicinal ointment.

The dressing needs to be changed 1-fold per day, but with strong ulcer soaking, the frequency of this procedure should be increased. For people with radiation injuries the drug is applied in the form of applications. For therapy and prevention of pressure sores, dressings are changed 3-4 times per day.

Regimen of medicinal cream.

It is used to activate the regeneration processes for oozing types of ulcers and wounds. Upon completion of therapy with the use of the gel, it is used to prevent the appearance of pressure sores. When treating and preventing the development of radiation injuries, you should use the cream 2-3 times a day.

Schemes of use of ointment.

Ointment prescribed for long-term treatment of ulcers and wound lesions - after the end of therapy with the use of gel and cream. The treatment of epidermal lesions is performed using dressings soaked in the preparation, which are changed up to 4 times per day. When using an ointment to prevent bedsores or radiation injuries, changing the dressing requires 2-3 times per day.

In the treatment of burns, ointment is applied very carefully - in order not to damage the epidermis. Therefore, it is recommended to apply the substance to the dressing, and then apply it to the affected area.

[7]

Use Actuverine during pregnancy

Actovegin can be used during pregnancy. Often the drug is used to prevent disorders in the development of the fetus associated with placental insufficiency.

However, the drug is sometimes used at the planning stage of conception. During this period, it is required to activate the processes of the uteroplacental blood flow, stabilize the metabolic activity of the placenta and gas exchange.

Because the composition of a therapeutic agent contains natural elements, it does not cause negative reactions in the fetus.

During pregnancy, a portion of the drug solution is administered intravenously (it is in the range of 5-20 ml). Apply the drug must be every day or every other day. V / m use is carried out with the selection of individual portions (taking into account the reasons for the use of Actovegin ). Therapy usually lasts from 1-1.5 months.

Contraindications

Main contraindications:

• pulmonary puffiness;
• anuria or oliguria;
• fluid retention;
• with the need to use a dropper - failure of the cardiac function of decompensated nature;
• intolerance to the drug.

Side effects Actuverine

The drug is often tolerated without any complications when using any of its therapeutic forms.

Administration of the medication may lead to the development of the following side effects:

• signs of allergy: occasionally swelling, hot flushes, urticaria and hyperhidrosis may occur, and the temperature may increase;
• disorders of the digestive tract: diarrhea, vomiting, pain in the epigastric zone, nausea and dyspepsia symptoms;
• manifestations affecting the function of the cardiovascular system: pallor of the epidermis, tachycardia, dyspnea, pain in the heart, and in addition, a decrease or increase in blood pressure values;
• Disorders of NA: headaches, paresthesia, feeling of excitement or weakness, dizziness, as well as tremor and loss of consciousness;
• problems with the work of the respiratory system: pain in the throat, feeling of suffocation or compression inside the sternum, problems with swallowing and increased breathing;
• lesions of the musculoskeletal system: pains affecting bones with joints or lower back.

When the patient has the above described negative symptoms, it is required to cancel the use of the medication and to carry out symptomatic procedures.

[6]

Overdose

When using Actovegin in extremely high portions, negative manifestations associated with the work of the gastrointestinal tract may develop. To eliminate them perform symptomatic measures.

Storage conditions

Actovegin must be kept in a place protected from sunlight. Temperature values - within 25 ° C.

Shelf life

Actovegin can be used within 5 years from the moment of release of the therapeutic agent; Infusion fluid has a shelf life of 36 months. If, after performing an intravenous injection, the remnants of the substance remain in the vial, they must be disposed of.

Application for children

Children are prescribed a therapeutic agent for treatment of pathologies that are neurological in nature (they arise due to complications during pregnancy or problems during childbirth). Injections can be used for babies younger than 12 months, but during therapy it is necessary to strictly follow all the instructions.

When using intramuscular injections of drugs, the portion size is selected depending on the state of the child.

In case of lesions with a mild severity, you need to take pills - 1 well per day.

Newborns usually use the medicine in portions of 0.4-0.5 ml / kg, 1 times per day. The introduction of the substance occurs intramuscularly or intravenously.

Analogs

Analogues of the medication are the drugs Solcoseryl, Cortexin, Curantil-25 with Cerebrolysin, and Vero-Trimetazidine.

Reviews

Actovegin in the form of injections is considered to be quite an effective means for therapy in a variety of pathologies. There are many reviews left by parents who gave shots to their babies. Sometimes there was a clear improvement in the patient's condition with pathologies of a neurological nature.

But there are also reports from parents, where it is noted that children are rather difficult to tolerate intramuscular injections of medication - because they are extremely painful. Occasionally severe allergic symptoms have been observed.

Pregnant women also leave mostly positive reviews of the drug.

Often, comments are also left by patients who used the tablet form of the drug. Both physicians and patients generally speak positively of this type of release.

Messages regarding the gel, cream and ointment are also positive - the medicine accelerates the regeneration of wounds, burns and ulcers, and is also convenient to use.