Ajithim

Ajithim is a medicine for improving digestion. Consider the rules of its use, dosage, contraindications, the possibility of interaction with other drugs.

The drug is included in the category of pancreatic enzymes: amylase, lipase and protease. It facilitates the process of digestion, accelerates the digestion of fats, proteins and carbohydrates. Promotes complete absorption of microelements in the small intestine. Used for diseases of the pancreas. Its action is associated with compensating for the lack of exocrine function and improving the digestive process.

Indications Ajithim

With many diseases of the pancreas used drugs aimed at accelerating the process of digestion, that is, facilitating the work of the body. Indications for the use of Ajim are based on the insufficiency of the exocrine function of the pancreas of different genesis:

• Chronic pancreatitis.
• Total gastroectomy.
• Improve digestion in overeating.
• Cystic fibrosis.
• Pancreatectomy.
• Oncological diseases of the digestive tract.
• Condition before and after surgery with anastomosis on the digestive tract (resection of the stomach according to Billroth AI, obstruction of the biliary or pancreatic duct with exocrine pancreatic lesions).
• Preparation for ultrasound or radiography of the abdominal cavity.

The drug is dispensed without a prescription, but before using it is better to consult with your doctor.

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Release form

Agzyme has a tablet form of release. In a cardboard box, three blisters each have 10 tablets each. The active ingredient is pancreatin, each tablet contains 212.5 mg (corresponds to enzymatic activity: amylase - 4500 FIP / ED, lipase - 6000 FIP / ED, protease - 300 FIP / ED).

Auxiliary components are: silicon colloidal dioxide, propylene glycol, macrogol, microcrystalline cellulose and other substances. Tablets are round in shape, covered with a protective coating that does not dissolve in the acidic contents of the stomach, protecting the digestive enzymes from the action of the pH of the gastric juice.

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Pharmacodynamics

By its mechanism of action, Ajimine is similar to substances that improve digestion: lipase, protease, amylase. Pharmacodynamics of pancreatic enzymes promotes the digestion of fats, proteins and carbohydrates, improving the absorption process in the small intestine. Enzyme preparation is involved in biochemical reactions and physiological functions of the body. The active substances compensate for the exocrine insufficiency of the pancreas function.

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Pharmacokinetics

After ingestion, the active components are released from the tablet shell only in the alkaline medium of the small intestine, since the capsules are protected from the action of gastric juice. Pharmacokinetics indicates maximum enzymatic activity 30-45 minutes after oral administration.

Since the active components of the drug are not absorbed into the digestive tract, no systemic blood flow is detected. Agzyme is inactivated by hydrolysis and digestion processes. Some of the non-hydrolyzed enzymes are excreted unchanged with feces, the rest with urine.

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Dosing and administration

In order for the treatment to be effective, the method of administration and dose of Ajzyme is chosen by the attending physician, individually for each patient. Dosage depends on the degree of failure of the pancreas.

Adult patients are prescribed 1-2 tablets 3 times a day during or after a meal. Tablets must be swallowed whole, do not chew and drink with water. Daily dosage for adults - 6 tablets, but if necessary (severe digestive disorders) can be increased. The maximum available dosage is 16 tablets per day.

Dosage for children is prescribed by a doctor, it is calculated 1 tablet per 12 kg of body weight per meal. The duration of treatment depends on the severity of the disease, so the drug may take several days, up to several months and even years. With prolonged therapy, it is necessary to additionally take iron preparations. 

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Use Ajithim during pregnancy

The safety of use of Ajimine during pregnancy and lactation is not well understood. The use of this tablet is possible only with the appropriate medical purpose. That is, in those cases when the theoretical benefits for the metric are higher than the possible risks to the fetus.

Contraindications

Enzyme means, like other drugs, has a number of contraindications to use. The main ones are:

• Intolerance of active components.
• Acute stage of pancreatitis.
• The age of the patients is less than 4 years.

The drug does not affect the management of machinery and vehicles.

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Side effects Ajithim

Failure to comply with the conditions of use of the medicament may cause side effects. Agizim in some cases provokes skin allergic reactions (itching, burning, hyperemia), discomfort in the epigastric region, attacks of nausea and vomiting, diarrhea and constipation. To eliminate these reactions, it is recommended to stop taking the drug and contact your doctor for correction of therapy.

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Overdose

Prolonged use of Agzyme and its high doses cause adverse reactions. Overdosing manifests as hyperuricosuria (more than 25 tablets), that is, increased uric acid in the blood plasma. For treatment, it is necessary to adjust the dose of the medicine and monitor the vital signs of the organism.

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Interactions with other drugs

The possibility of interaction of the enzyme agent with other drugs is determined by the attending physician. During therapy, you must additionally take folic acid, as the enzymes of the pancreas reduce its level.

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Storage conditions

Tablets should be kept in a place protected from sunlight, moisture, and inaccessible to children. According to the storage conditions, the temperature should not exceed 25 ° C. Non-compliance with these recommendations leads to premature deterioration of the drug.

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Shelf life

Agzyme must be used within 36 months from the date of manufacture. The expiry date is indicated on the package of the drug, it is contraindicated to take the tablet at its expiration.