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Health

Aertal

, medical expert
Last reviewed: 03.07.2025
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Aertal is a medicine that belongs to the NSAID group.

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Indications Aertal

The drug is indicated for the treatment of pain and reduction of inflammation in patients with rheumatic processes in soft tissues or lumbago, as well as with scapulohumeral periarthritis.

In addition, Aertal is used to relieve toothache and as part of the symptomatic treatment of patients with osteoarthritis, rheumatoid arthritis or Bechterew's disease.

Release form

Available in tablet form. One blister contains 10 tablets. One package contains 2 or 6 blister strips.

Pharmacodynamics

The active substance of the drug is aceclofenac, which suppresses the activity of the enzyme cyclooxygenase. As a result, the processes of synthesis of cytokines that provoke inflammation (including prostaglandins I2, as well as conventional PG) are slowed down. The drug has analgesic, antipyretic and anti-inflammatory properties.

The high activity of aceclofenac in the tissues of the PNS, as well as soft tissues, allows the drug to eliminate severe pain, and also to reduce swelling and stiffness of the joints that occurs in the morning in patients suffering from rheumatic pathologies.

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Pharmacokinetics

After oral administration, the drug is quickly absorbed from the gastrointestinal tract. The active substance reaches its peak concentration in the plasma 1.5-3 hours after taking the drug.

Aceclofenac effectively binds to plasma proteins (mainly albumins). High levels of the substance are also observed in synovial fluid. Only a small portion of the drug undergoes the metabolic process.

The active component is mainly excreted through the kidneys (both as decay products and unchanged). The half-life is 4 hours.

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Dosing and administration

The medicine is taken orally - the tablet should be swallowed whole, without chewing or crushing, and washed down with water. The duration of the treatment course, as well as the dosage, is prescribed by the attending physician - they are individual for each individual case.

For adults, the dosage is usually 1 tablet twice a day.

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Use Aertal during pregnancy

The medicine should not be prescribed to pregnant women.

If it is necessary to use Aertal during breastfeeding, you should first consult with your doctor about stopping breastfeeding.

Contraindications

Among the contraindications:

  • individual intolerance to the active substance of the drug, as well as other NSAIDs;
  • the patient has ulcers of the gastrointestinal mucosa (at the acute stage), bleeding in the intestines or stomach (or if this is suspected), kidney or liver dysfunction, as well as problems with blood clotting and hematopoiesis processes;
  • the period after coronary artery bypass grafting, and also for the treatment of patients suffering from hyperkalemia;
  • children and adolescents under 18 years of age.

The drug is prescribed with caution to patients with a history of renal/hepatic pathologies or gastrointestinal diseases, as well as to people with high blood pressure, bronchial asthma, coronary heart disease, low BCC, diseases caused by Helicobacter pylori, as well as severe somatic pathologies.

At the same time, it is necessary to carefully prescribe the drug to patients with disorders of cerebral circulation, lipid metabolism imbalance, diabetes, and also to the elderly and those who drink alcohol and smoke.

Side effects Aertal

As a result of taking the drug, patients may develop the following side effects:

  • Gastrointestinal tract and liver: vomiting with nausea, bowel disorders and pain in the epigastrium. In addition, digestive disorders, spasms in the smooth muscles of the intestine, loss of appetite, and an increase in the activity of liver transaminases. Ulcers and erosions may also appear on the mucous membranes of the gastrointestinal tract, pancreatitis, stomatitis or hepatitis may develop, and in addition, bleeding in the gastrointestinal tract;
  • PNS and CNS organs: headaches or dizziness, sleep/wake disorder, high excitability, memory impairment, development of seizures, emotional weakness, and tremors of the extremities. Meningitis in aseptic form was observed in isolated cases;
  • sensory organs: problems with hearing or vision, the appearance of noise in the ears, and also a disorder of the taste buds;
  • urinary system organs: the appearance of blood in the urine or swelling, the development of albuminuria, tubulointerstitial nephritis or renal failure;
  • cardiovascular and hematopoietic systems: disturbances in heart rhythm, increased blood pressure, coronary heart disease, congestive heart failure, thrombocytopenia or leukopenia, development of agranulocytosis or anemia (among the forms are aplastic and hemolytic);
  • allergies: skin rashes, itching, development of urticaria, erythroderma, eczema or vasculitis. In addition, bronchospasms, malignant erythema multiforme and toxic epidermal necrolysis. Angioedema or anaphylaxis may also develop.

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Overdose

Taking the drug in large doses may cause dizziness with headaches, vomiting along with nausea, abdominal pain, as well as hyperventilation in combination with increased convulsive readiness.

There is no specific antidote to eliminate these manifestations. In such cases, gastric lavage, the use of enterosorbents, and symptomatic treatment are required. Forced diuresis and hemodialysis procedures will not be effective.

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Interactions with other drugs

Combination with phenytoin, digoxin, and lithium drugs can increase their concentration in plasma.

The drug reduces the effectiveness of antihypertensive and diuretic drugs.

The combination of Aerthal with potassium drugs and potassium-sparing diuretics can cause the development of hyperkaluria or hyperkalemia.

Aertal increases the ulcerogenic properties of other NSAIDs, as well as GCS.

The combined use of the drug with selective serotonin reuptake blockers increases the risk of gastrointestinal bleeding.

The simultaneous use of Aerthal and cyclosporine increases the nephrotoxic properties of the latter.

The drug may provoke changes in blood sugar levels, which will require a dosage adjustment of antidiabetic drugs in patients suffering from diabetes.

Aertal increases the concentration of methotrexate in plasma, so it is necessary to observe an interval between the use of these drugs (at least 24 hours).

Aspirin in combination with Aertal reduces the concentration of the latter's active substance in plasma.

Combination of the drug with anticoagulants and antiplatelet agents increases the risk of bleeding.

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Storage conditions

The medicine should be stored in standard conditions for medicinal preparations - a dry, dark place, inaccessible to children. Temperature - within 15-30 degrees.

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Shelf life

Aertal is permitted to be used for 4 years from the date of manufacture of the drug.

Attention!

To simplify the perception of information, this instruction for use of the drug "Aertal" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

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