Aekol

Aecol is a medicine used to treat ulcers and wounds - it helps to cicatrize and heal.

[1], [2], [3], [4]

Indications Aekol

It is used in the complex treatment of ulcers of the duodenum and stomach, and in addition to this nonspecific form of ulcerative colitis and conditions after gastric resection.

It is also shown locally: for healing of mucosal cracks in the rectum (also in conditions after operations for cutting cracks), with hemorrhoids, proctosigmoiditis, trophic, decubital or varicose ulcer form, and in addition with scleroderma, eruption of the uterine neck and colpitis. Also for the treatment of endocervicitis, wounds of purulent-necrotic type, infected burns (grade 2-3) and conditions after the procedure of autodermoplasty.

Release form

It is available in the form of an oily solution in 50 or 100 ml vials. One package contains 1 bottle.

Pharmacodynamics

Combined vitamin complex, the properties of which are determined by the action of the components contained in its composition (retinol, tocopherol and vitamin K). The medicine has antiulcer and metabolic action, and besides it stimulates reparation processes and accelerates wound healing. It also has an anti-inflammatory and antioxidant effect, and besides restores the circulatory process in the capillaries, stabilizes their permeability and permeability of tissues. In addition, it has hemostatic properties.

Dosing and administration

Take the medicine should be taken orally, before meals (for 30-40 minutes). For adults, the dosage is 5-10 ml (or 1-2 teaspoons) 2-3 times per day for 4-5 weeks.

If necessary, after a preliminary medical consultation, it is possible to repeat the treatment course after six months.

In proctology, it is used topically - in this case either tampons moistened in solution or microclysters with a volume of 30-50 ml are used for 10-12 days. In gynecology, tampons wetted in solution are also used. The duration of the course is 1-15 medical procedures.

In case of skin lesions, it is applied to injured places, which must be previously cleaned from the necrotic formations that appeared on them. It is applied in the form of oil dressings, until the epithelization with granulation appears.

[8], [9]

Use Aekol during pregnancy

Oral medication during breastfeeding and pregnancy is prohibited.

Contraindications

Use of the drug is prohibited locally if there is an individual intolerance to the drug components.

Contraindications for oral administration:

• children under the age of 14;
• hypervitaminosis of type A and E;
• an overdose of retinoids;
• the presence of obesity or thyrotoxicosis;
• the stage of exacerbation of myocardial infarction;
• severe form of cardiosclerosis;
• Decompensated heart failure;
• cholelithiasis;
• chronic form of pancreatitis or a severe stage of liver failure;
• chronic form of glomerulonephritis;
• acute or chronic stage of nephritis;
• hyperlipidemia or hypercoagulation;
• presence of thromboembolism;
• chronic form of alcoholism;
• Bénier-Böhk-Schauman disease (also in history);
• lack of G6FD.

Side effects Aekol

Due to the use of the drug, the following adverse reactions may develop:

• organs of the National Assembly: a feeling of lethargy, drowsiness or weakness, fatigue, irritability, insomnia, headaches, a sense of discomfort and the development of seizures. In addition, there may be visual or taste disorders, increased intraocular pressure, excessive sweating, increased temperature, and a feeling of heat;
• organs of the ODA: a violation in the nature of gait, pain in the bones of the legs, bone changes observed on radiographs;
• Gastrointestinal organs: loss of appetite, dryness in the oral cavity, the appearance of aft, dyspepsia with a feeling of discomfort in the epigastrium, pain in the abdomen, vomiting with nausea, diarrhea, weight loss;
• (there may be an exacerbation of hepatic pathologies, as well as an increase in the activity of liver transaminases and alkaline phosphatase).
• organs of the urinary system: development of nocturia, pollakiuria or polyuria;
• organs of the hematopoiesis system: hemolytic form of anemia, development of hyperprothrombinemia or hyperthrombinemia, and in addition thromboembolism. Also in patients with tocopherol deficiency, hematolysis is possible;
• organs of the cardiovascular system: development of tachycardia, temporary lowering of blood pressure, weak pulse filling;
• allergies: development of urticaria or erythema, rash on the skin, itching, dryness and flaking. In addition, spasms of bronchial tubes, facial hyperemia, cracks in the skin of the lips, palms, soles and a nasolabial triangle may appear patches of yellow-orange color. Puffiness under the skin may also appear. Single on the first day of use, there may be a patchy-papular rash that itches (with the use of drugs being discarded). There are also possible reactions at the site of application of drugs;
• other: alopecia, menstrual disorder, the development of hyperbilirubinemia or hypercalcemia, as well as photophobia.

After lowering the dosage or temporarily abolishing the use of drugs, side effects go by themselves.

In the case of skin diseases, the use of the drug for 7-10 days in large doses can provoke an aggravation of the local inflammatory processes (additional treatment is not necessary in this case, the symptoms eventually pass). This effect develops because of the immuno- and myelostimulating properties of drugs.

Due to the long-term use of tocopherol in large daily dosages (400-800 mg), hypothrombinemia may increase. In addition, creatinuria, dizziness, and bleeding in the digestive tract may also occur.

[5], [6], [7]

Overdose

Signs of drug overdose are manifestations of hypervitaminosis of types A, E or K.

Overdose of retinol: a feeling of irritability, the appearance of dizziness or confusion, and in addition diarrhea and dehydration of the body in severe form. Also, a generalized rash on the skin is possible, which later begins to peel off large balls, starting with the face. In addition, there may be bleeding from the gums, dryness of the oral mucosa and the appearance of ulcers on it, as well as peeling of the skin on the lips. When palpation of long tubular bones, severe pain can be felt (due to subperiosteal hemorrhage).

Acute or chronic form of hypervitaminosis type A manifests itself in the form of severe headaches, fever, vomiting, drowsiness, vision problems (begins to double in the eyes), dry skin and pain in muscles with joints. In addition, the size of the spleen and liver may increase, pigment spots may appear, jaundice may develop; can change the picture of blood, disappear appetite and there is a loss of strength. With a severe degree of illness, seizures begin, there is a weakness of the heart, and in addition, hydrocephalus develops.

In these cases, symptomatic therapy is required.

Due to the use of an increased dose of tocopherol (400-800 mg per day for an extended period of time), a general feeling of weakness, headaches, dyspepsia and fatigue may develop. It is also possible to increase the risk of thromboembolism in people with a predilection for this disease. In addition, the cholesterol index may increase.

To eliminate manifestations, excretion of tocopherol from the body is required, and then symptomatic treatment is performed.

In the case of hypervitaminosis of type K, hyperprothrombinemia or hyperthrombinemia, or hyperbilirubinemia, and jaundice may develop and the activity of hepatic transaminases may increase. Also possible constipation, diarrhea, pain in the abdomen, skin rash, and in addition a sense of general overexcitation.

As a treatment, a drug cancellation is required. Appointed anticoagulants, which must be taken, controlling the indicators of the system of blood coagulation. Symptomatic therapy is also performed.

Interactions with other drugs

The drug is not allowed to be consumed with estrogen (this increases the risk of hypervitaminosis type A), but also with cholestyramine and nitrites, because they interfere with the absorption of Aecol.

You can not combine it with indirect anticoagulants, but also with silver or iron.

Retinol can not be combined with aspirin and hydrochloric acid. In addition, it weakens the anti-inflammatory properties of GCS.

When combining retinol with vaseline oil, there may be a violation of absorption of the vitamin in the intestine.

Tocopherol promotes rapid absorption and absorption of retinol. It should be taken into account that large doses of tocopherol can provoke a deficiency of retinol in the body.

Tocopherol increases the effectiveness of the medicinal action of steroid drugs and NSAIDs (such as ibuprofen, diclofenac sodium, and prednisolone), and it also reduces the toxic effects of cardiac glycosides (such as digitoxin with digoxin) and vitamin D with retinol. Kolestyramin, and in addition colestipol with mineral oils weaken the absorption of tocopherol.

Tocopherol can increase the effect of anticonvulsants in patients with epilepsy, in which an elevated level of lipid peroxidation products is observed in the blood. Tocopherol with its degradation products is a vitamin K antagonist.

Phylloquinone weakens the effect of indirect anticoagulants (among them coumarin derivatives, as well as indanedione). It does not affect the anticoagulant activity of the substance heparin. In the case of combination with inhibitors and aggregates of fibrinolysis, their haemostatic effect is enhanced.

When combined with antibiotics with a wide range of effects, and besides salicylates (in high dosages), quinine and quinidine, and sulfanilamide drugs, an increase in the dosage of phylloquinone is necessary.

Antacid drugs slow the absorption of the vitamin because bile salts are deposited in the upper part of the small intestine. Colestramine with colestipol, and in addition mineral oils, dactinomycin and sucralfate also slow the absorption of vitamin K.

When combined with hemolytic drugs, the risk of adverse reactions increases.

[10], [11]

Storage conditions

To keep the medicine is required in standard conditions for medicines - not accessible to children, dry dark place. The temperature is a maximum of 25 ° C.

Shelf life

Aekol is allowed to be used within 2 years from the date of manufacture of the medicine.