You are here


Adelfan is a combined remedy that helps lower blood pressure (arterial pressure). The active components of the drug are reserpine, as well as dihydralazine.


C02LA51 Резерпин и диуретики в комбинации с другими препаратами

Indications of adelfana

A drug used for hypertension (in the middle and light forms), especially if the disease has arisen for an unknown reason.

Release form

Produced in the form of tablets. One package contains 250 tablets.


Reserpine exerts a neurotropic vasodilating effect on the body. Adelphan lowers blood pressure and improves sleep. As a result of using the drug in neurons, the saturation with neurotransmitters decreases, which causes its antipsychotic effect.

Tablets improve the peristalsis of the gastrointestinal tract, increase the glomerular reaction, and increase the volume of blood flow in the liver. In addition, the drug reduces the metabolic rate, causes miosis and hypothermia. It also promotes deepening of respiratory movements. The constant effect from the use of Adelphan begins to appear after 2-3 weeks. Since the start of therapy.

Under the influence of dihydralazine, the tone of the smooth myocytes of the arterioles decreases, the blood flow increases, and the resistance force in the vessels of such organs as the kidneys, the brain, as well as the skin and heart.


After oral administration of reserpine is soon absorbed, the systemic bioavailability is 50%. The relative average Vd of the reserpine is 9.1 l / kg (with fluctuations in the range of 6.4-11.8 l / kg). With blood plasma proteins bind more than 96% (with albumins and lipoproteins). The active substance in the liver is metabolized, and also in the intestine. The main products of metabolism are trimethoxybenzoic acid together with methyl reserpate. It is excreted from the blood plasma together with metabolites in 2 stages: the half-life in the α-phase is 4.5 hours, and in the β-phase - 271 hours. The average half-life of the unchanged component is 33 hours. The overall cleansing ratio of reserpine has an average value of 245 ml / minute.

After internal reception, dihydralazine is soon absorbed, mainly remaining in the blood plasma unchanged. In the process of metabolism of this component, hydrazone substances are also formed. About 10% of dihydralazine resides in the blood plasma under the guise of hydralazine. Metabolization of the substance is mainly carried out by oxidation (hydrazones are formed at the same time), as well as acetylation. In this case, the half-life of the unchanged basic component takes on average 4 hours. The average total purification rate is 1450 ml / minute. In the first 24 hours after ingestion, approximately 46% of the dose used is excreted from the body (predominantly the intestine), mainly in the form of metabolites. Approximately 0.5% of the dose of the drug in unchanged form leaves with urine.

Use of adelfana during pregnancy

Adelfan should be used with caution in 1 and 2 trimesters of pregnancy. In the case of finding a patient on the 3rd trimester of pregnancy from the use of the drug must be abandoned, as in later terms it can cause lethargy in the child, or anorexia.


Among the contraindications to Adelphan's admission:

  • The state of depression;
  • Parkinson's disease;
  • Postponed in the recent past myocardial infarction;
  • Epilepsy;
  • An aggravated ulcer;
  • Arrhythmia or angina in severe form;
  • Bright tachycardia;
  • Problems with liver function;
  • Severe form of renal insufficiency;
  • Hypersensitivity to the components of the drug - reserpine or dihydralazine;
  • Breastfeeding period;
  • The age is under 18 years.

Side effects of adelfana

Among the side effects of the drug reception the following disorders:

Redness of the eyes, skin rashes, disturbances of motor function of the digestive process, bradycardia, dizziness, feeling of general weakness, and shortness of breath. In some cases, there may be depression, feeling of anxiety, insomnia, and symptoms of Parkinson's disease (a disorder of motor coordination with the occurrence of jitter, as well as a decrease in range of motion).

Dosing and administration

Adelfan at the first stage of treatment is prescribed in a dosage of 1 table. Three times a day after eating. If there is such a need, the dosage can be increased to 2 tables. Three times a day. After the therapeutic effect is achieved, the daily dosage of the medicine is gradually reduced.

Interactions with other drugs

Other drugs that lower blood pressure, increase the hypotensive effect of Adelphane. The combination of reserpine with cardiac glycosides lowers the heart rate, thereby increasing the risk of arrhythmia. Reduces the effectiveness of antiparkinsonian drugs, as well as morphine and holinoblokatorov. When combined with methyldopa, the likelihood of developing a depressive state increases. Increases the central effect of hypnotics, drugs used as inhalation anesthetics, barbiturates, antihistamines, medications containing ethanol, as well as tricyclics. In the case of combined administration with MAO inhibitors, there is an increase in blood pressure and development of hyperreactivity.

Tricyclics, antipsychotics, drugs containing ethanol, and diazoxide in combination with Adelphan increase the hypotensive effect of hydralazine sulphate.

Storage conditions

The drug should be stored in a dry place, closed from sunlight, at a maximum temperature of no more than 30 ° C.

Shelf life

Adelfan allowed to use for 5 years from date of manufacture.

Found an error? Select it and press Ctrl + Enter.

Share on social networks


To simplify the perception of information, this instruction for use of the drug "Adelphane" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

You are reporting a typo in the following text:
Simply click the "Send typo report" button to complete the report. You can also include a comment.