Additive

Additive is a complex vitamin and mineral preparation of the multivitamin group. The manufacturer is Natur Produkt Pharma (Poland).

[1], [2]

Indications Additive

The multivitamin additive complex is used in the treatment of hypo-and vitamin deficiencies and the replacement of mineral deficiencies in adults and children over 12 years of age, with increased demand for vitamins and minerals during recovery from severe diseases, antibiotic therapy, and intensive physical and mental loads.

[3], [4], [5], [6]

Release form

The form of the drug - effervescent tablets with orange flavor. Each tablet contains: vitamin B1 (3.75 mg), vitamin B2 (7 mg), vitamin B3 (37.5 mg), vitamin B5 (25 mg), vitamin B6 (4.25 mg), vitamin B7 12.5 μg), vitamin B9 (0.5 mg), vitamin B12 (12.5 μg), vitamin C (187.5 mg), vitamin E (30 mg), as well as sodium hydrogen carbonate, potassium dihydrogen phosphate, potassium hydrogen carbonate , calcium carbonate and magnesium carbonate.

[7], [8], [9], [10], [11]

Pharmacodynamics

The water-soluble vitamins of group B, which are part of the Additive drug, are absorbed into the digestive tract and enter the blood plasma.

Vitamin B1 provides the transformation into energy of nutrients coming from food; B2 supports the synthesis of hemoglobin; B3 (nicotinic acid, vitamin PP) promotes the biosynthesis of many hormones that provide psychosomatic reactions and functions of the central nervous system.

Vitamin B5 is needed to regenerate tissues and protect cells of the epidermis and mucous membranes from pathogenic microbes, B6 is needed to maintain carbohydrate metabolism, normal activity of the autonomic and central nervous system, the production of hemoglobin and hormones.

Vitamin B7 (biotin) is important for normal cholesterol levels, provides a good condition for the skin, hair and nails. B9 (folic acid) provides the synthesis of amino acids, proteins and DNA. B12 promotes the regeneration of cells and the synthesis of blood cells, ensures the stability of the structure of nerve fibers.

Vitamin C is a powerful antioxidant that increases the resistance of the body to infections, positively affects the condition of the walls of blood vessels, takes part in the synthesis of endogenous collagen. Vitamin E (tocopherol) - an antioxidant and antihypoxant - protects cells from the action of free radicals and prevents the development of atherosclerosis, and also helps to maintain a normal level of production of immunoglobulins.

Included in the preparation of Additive calcium, sodium, magnesium and phosphorus are involved in many biochemical processes of the body and regulate the permeability of cell membranes.

[12], [13], [14], [15], [16]

Pharmacokinetics

Pharmacokinetics Additive has not been studied, but vitamins do not accumulate and are excreted from the body.

[17], [18], [19]

Dosing and administration

The way additive is applied - inside. The daily dose of the drug - 1 tablet, which must be dissolved in 200 ml of water and drink after eating. The standard course of treatment is 30 days.

[25], [26], [27], [28]

Use Additive during pregnancy

The use of Additive during pregnancy is possible when the doctor evaluating the drug evaluates the ratio of benefit to the mother and the possible risk to the fetus.

Contraindications

The list of contraindications additive includes:

• individual hypersensitivity to the constituents of the drug;
• phenylketonuria (in the composition of the drug there is a food additive E951-a substitute for aspartame);
• children's age till 12 years;
• kidney disease, circulatory disorders and a tendency to form blood clots.

[20], [21], [22], [23]

Side effects Additive

The use of this vitamin complex can cause allergic reactions, nausea and vomiting associated with irritation of the stomach or intestines.

Staining of urine in orange is a consequence of excretion of vitamin B2 from the body, which is not a threat.

[24]

Overdose

In the official instruction for the drug, it was noted that no cases of overdose of Additive were reported.

[29], [30]

Interactions with other drugs

Additive should not be taken simultaneously with other vitamin preparations and medicines containing calcium, potassium and magnesium.

Vitamin B6 reduces the efficacy of the protoparaksonic drug levodopa. Vitamin B9 can reduce the anticonvulsant effect of the phenytoin drug used in epilepsy.

Simultaneous use of tricyclic antidepressants (iproniazide, nialomide, phenelzine, pyrlindole, etc.) and Vitamin Complex Additive reduces the effectiveness of vitamin B2; acetylsalicylic acid (aspirin) inhibits the release of vitamin C, and preparations based on mineral oils impair the absorption of vitamin E.

[31], [32]

Storage conditions

Storage conditions Additive: in a place inaccessible to children, in tightly closed form, at a temperature of + 18 ° C-25 ° C.

[33], [34], [35], [36], [37], [38],

Shelf life

Shelf life - 24 months.

[39]