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Adaptol
Last reviewed: 09.08.2022
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Indications of the adaptola
Adaptol is used:
- for the normalization of psychosomatic disorders of various ethologies, the removal of anxiety and the reduction of emotional tension with pronounced neuroses, stress and depression;
- for the correction of inadequate behavior in psychoses and schizophrenia;
- for the removal of pain in the heart, not associated with pathologies of the cardiovascular system;
- to reduce vegetative symptoms during menopause and with PMS;
- for the treatment of patients with paroxysms after closed craniocerebral trauma;
Adaptol is also used in the treatment of alcoholism at the stage of remission and for the withdrawal of symptoms of nicotine withdrawal from quitting smoking.
Release form
The form of the preparation: tablets of 300 and 500 mg.
Pharmacodynamics
Pharmacological action Adaptol is provided by the active substance tetramethyl-tetraazobicyclooctanedione (bicyclic urea derivative), which acts as an activator of the serotonin precursor of the amino acid tryptophan, increasing the intensity of the process of converting tryptophan to serotonin in serotonergic neurons. Dosed increase in serotonin has a regulating effect on increased psychoemotional reactions.
At the same time, the Adaptol preparation shows the properties of the adrenergic neuron blocker of postsynaptic membranes of the peripheral nervous system. Thanks to this, inhibition of the work of exciting cellular neurotransmitters is increased.
In addition, Adaptol promotes increased myocardial contractions and increases cardiac output, which accelerates the volume coronary blood flow and increases the saturation of blood with oxygen.
Pharmacokinetics
After ingestion of approximately 40% of the active substance, Adaptol binds to the red blood cells of the blood, the rest circulates freely in the bloodstream and can penetrate through the cell membranes. The level of bioavailability of the drug is about 80%.
The maximum concentration in the serum is reached after 25-30 minutes after taking the drug inside, the duration of the therapeutic action - up to 4 hours.
The active substance is not transformed and not cumulated. The drug Adaptol is completely excreted in the urine within 24 hours.
Dosing and administration
Adaptol tablets are taken orally. The standard single dose is 300 mg (1 tablet). It is prescribed to take the pill 2-3 times a day (regardless of food intake).
The maximum daily dose is -10 g, the maximum duration of the drug is 3 months.
To remove the symptoms of nicotine withdrawal, a single dose of 0.6-0.9 g, the drug is taken three times a day, the course of treatment -1.5 months.
Use of the adaptola during pregnancy
Contraindicated.
Contraindications
Contraindications to the use of this drug are: individual hypersensitivity to the components of its composition, as well as children under 10 years.
Since relevant clinical studies related to the use of the drug in the therapy of pregnant and lactating women have not been conducted, the use of Adaptol during pregnancy is contraindicated.
Side effects of the adaptola
Among the possible side effects of Adaptol are:
- allergic reactions;
- dyspeptic disorders (nausea, intestinal disorders);
- decrease in body temperature and blood pressure.
[8]
Overdose
Overdose of this drug leads to an increase in the manifestation of side effects. In case of an overdosage, gastric lavage should be performed.
Storage conditions
Storage conditions Adaptol: out of the reach of children, at a temperature of + 18-25 ° C.
Shelf life
Shelf life - 4 years.
[13]
Attention!
To simplify the perception of information, this instruction for use of the drug "Adaptol" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.