Adalat

Adalat is an excellent remedy in the fight against stable stenocardia. This medicine can be called one of the best of its kind. People take it with different symptoms. Basically, it has a positive effect on variant and stable angina pectoris. The drug cures spasms of coronary vessels and hypertensive crises.

[1]

Indications of the adalata

 The main indications for the use of Adalat are the use of the drug during stable angina pectoris. This disease is one of the most common among people of advanced age. But as you know, many "problems" are getting younger over the years. Therefore, angina may occur at an earlier age.

To cope with unpleasant symptoms and to alleviate the condition, one has to resort to stimulant medications. In this case Adalat helps. It is widely used with stable and vasospastic angina. In the field of his activity is Raynaud's syndrome and variant angina pectoris. A means is used to relieve hypertensive crises.

In dosage forms, the drug is used to stop coronary spasms. This tool has a wide range of "work". But despite all its remarkable properties, it is not recommended to take it alone. Adalat can be attributed to a number of strong medicines, which you only need to use under the supervision of your doctor.

[2], [3]

Release form

 In general, the form of release of the drug is standard. These can be capsules, tablets and infusions. Much depends on the complexity of a person's condition and his needs. In general, you can use the medicine in any form.

Thus, one capsule contains approximately 10 mg of nifedipine. This remedy helps to relieve a person's condition and produce relief of hypertensive crises. The package contains 50 capsules.

There are not so few varieties of medication. The main distinguishing feature of them is the content of nifedipine. In one capsule it can be from 10 to 20 mg. The number of tablets in this case does not exceed 40 pieces.

If it is a question of intracoronary Adalat, then 1 ml of the solution contains 0.1 mg of nifediline. Usually, to ease the symptoms, you need to enter 5 syringes of 2 ml. Dosage is appointed by the attending physician. The package contains one bottle, with a volume of 50 ml.

What form of output is optimal to say is difficult. After all, much depends on the state of a person and his needs. In general, Adalat is an excellent remedy to cope with angina pectoris.

[4], [5]

Pharmacodynamics

Pharmacodynamics of the drug is very positive. The drug is able to reduce the transmembrane flow of calcium ions. It occurs through slow calcium channels. They are located in myocarditis and smooth muscle cells.

Nifedipine is able to expand the coronary arteries during coronary spasm. The increased pressure is directly on the invariable segments of the vessels at the places of their permanent stenosis. Muscle tone is significantly reduced, the drug, thus, warns of the occurrence of coronary spasm.

Nifedipine significantly increases coronary perfusion and thereby improves oxygen supply to the myocardium. The need for it immediately decreases due to the fact that there is a peripheral vascular resistance.

If you take the medicine for a long time, then it can prevent the development of new atherosclerotic plaques in the coronary vessels. The active substance reduces the tone of smooth muscle cells and thus reduces peripheral vascular resistance. Adalat is the best medicine of its kind, it actively struggles with the arisen problem.

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Pharmacokinetics

Pharmacokinetics of the drug consists in a large content of active substance. So, the medicine can alleviate the symptoms of angina and prevent the development of hypertensive crises. All this is due to the content of nifedipine.

This substance is able to expand the coronary arteries during coronary spasm. Active action is on the unchanged segments of the vessels. Especially in places where partial stenosis occurs. The drug actively lowers the tone of the smooth muscles of the coronary arteries. It increases coronary perfusion and improves oxygen supply to the myocardium.

If you apply Adalat for a long time, you can prevent the formation of atherosclerotic plaques that arise on the vessels. At the beginning of treatment, active substance can manifest itself with tachycardia and even increase cardiac output. All this is because the drug does not compensate for vasodilation.

Nifedipine is able to enhance the excretion of sodium and water. The hypotensive effect of the substance may be manifested in patients with high blood pressure. With Reynaud's syndrome Adalat is able to prevent or reduce the spasm of the vessels of the extremities. 

[7], [8], [9]

Dosing and administration

The method of administration and dose of Adalat depends on the form of release of the drug. The condition of a person, his individual qualities and certain patient reactions to treatment are taken into account. Therefore, you can not take the medicine yourself. In this case, the dose should be clearly calculated.

Adalat in the form of capsules is prescribed for 1 capsule up to 3 times a day. If necessary, the dose is increased to 6 doses per day. When a patient suffers from hypertensive disease, he should consume no more than 3 capsules per day. If necessary, the dose is doubled.

To suppress the hypertensive crisis at one time it is worth to drink a capsule of medicine. If necessary, the reception is repeated after 30 minutes. Making the interval shorter is not recommended, perhaps, the development of dangerous hypotensive conditions.

During Reynaud's syndrome, you should take 1 capsule 3 times a day. If necessary, the dose doubles boldly. It is advisable to swallow the capsules whole and drink plenty of water. Eating in this case does not matter.

If there is a threat of developing an attack of angina, an active substance is used. It is quickly absorbed through the mucous membrane of the mouth. An empty capsule can also be swallowed. When a person feels better, he is prescribed fast-retard tablets. Take them need not chewing, the active substance will start to stand out when the capillary is dissolved inside the body. Between capsules should take at least 2 hours.

Rapid-retard tablets are another form of drug release. In this case, it is used to relieve tension and hypertension. It is advisable to take 1 tablet 2 times a day. If, two weeks after the start of the medication, there is no improvement, you will have to resort to another quick-acting form of the medicine. Tablets should be swallowed and washed down with plenty of fluids.

Parenteral administration. During such use of the drug, it is necessary to monitor the pressure and heart rate. At one time, 0.1-0.2 mg of nifedipine is administered. If there is severe stenosis of the coronary arteries, the dose is increased to 1 mg. The drug is effective for 3-15 minutes. The introduction of the medicine is carried out during the invasive activities. The infusion rate should not exceed 0, 0208-0, 0104 mg / min. After 3 days, it is possible to re-introduce Adalat.  

[16],

Use of the adalata during pregnancy

Use of Adalat during pregnancy is in question. To say that it contains an unfavorable substance, it is impossible. But, despite this, the medicine is one of the most powerful of its kind.

During the first trimester, the mother's body is affected by negative factors from the outside. Immunity weakens and thus allows various infections to penetrate inside. That is why the reception of strong drugs during this period is prohibited. A weak organism will not be able to take them properly. Moreover, such an impact will cause irreparable harm to the baby.

Therefore, taking Adalat during pregnancy is not recommended. Naturally, this question is solved by the attending physician. Only he can decide what is allowed and what is forbidden. But in any case, during the first trimester of pregnancy to take a remedy is not worth it.

How will the drug affect the mother and child, it is difficult. Therefore, to experiment and take Adalat on its own is strongly discouraged.

Contraindications

The main contraindications to the use of Adalat are the increased sensitivity to the components of the medication. Basically it is about nifedipine. It is this substance that performs the basic "functions" in this medicine. Thanks to him, relief occurs and angina recedes.

But despite such positive properties, nifedipine can also do harm. Therefore, people who do not tolerate this substance, can not take the remedy in any case. This can lead to serious problems. An allergic reaction, provoked by the drug, can lead to serious problems.

If a person has an acute period of myocardial infarction, then it is desirable to refuse taking the medication. It could aggravate the situation. During pregnancy, the drug is under strict prohibition. It can damage the developing organism of the baby. The period of breastfeeding is also prohibited. To protect your own health, it is worth consulting with a doctor. Only after this, you can start taking Adalat.

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Side effects of the adalata

Side effects of Adalat can occur only at the beginning of the treatment process. Usually they are of a weak, temporary nature. This can be a headache, flushing of the face and other parts of the body. All this is accompanied by a slight burning, palpitations, shades, nausea and increased excitability.

Suddenly, gynecomastia manifests itself, but it immediately disappears after the drug has been withdrawn. There is such a phenomenon mainly in men of advanced age. With prolonged treatment, gingival hyperplasia can manifest itself.

In the most rare cases, hyperglycemia is not excluded. True, this phenomenon can easily go into a violation of vision, as well as an increase in daily diuresis. Slightly impaired liver function, there is exfoliative dermatitis and other allergic reactions.

Lowering the pressure can lead to collapse. A sharp decrease in it is possible in patients suffering from malignant hypertension and hypovolemia. If a person has stable angina, then within an hour after taking the drug, pain can arise behind the sternum. There were isolated cases of asystole, bradycardia and even ventricular tachycardia. But only after intravenous administration of the drug. Adalat must be taken with extreme caution.

[14], [15]

Overdose

 Whether there is an overdose Adalat and what to do or make in this case? Naturally, no one is immune from this negative factor. But, to a large extent, everything depends on the person himself. If you follow the instructions and do not increase the dose yourself, nothing terrible will happen.

The cardiovascular system requires special attention to itself. Therefore, neglect your own health in any case impossible. Increasing the dose can lead to serious vascular problems.

Most of the cases associated with overdose is due to the patient's own fault. This suggests that you do not have to harm yourself to your own health. In general, the symptoms of an overdose are simple, a person feels headache, nausea, dizziness.

Much depends on how much the drug was taken. In any case, it is necessary to do a gastric lavage and seek help in the hospital. Adalat is a powerful drug that can both improve and worsen a person's condition.

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Interactions with other drugs

What can I say about interactions with other drugs in this medicine? The fact that the hypotensive effect of the drug may well increase during the use of other drugs. Therefore, it is worth keeping an eye on what kind of medicine a person uses.

Thus, cimetidine significantly increases the level of nifedipine in blood plasma. This contributes to the antihypertensive effect of the drug. When combined with B-adrenoblockers, hypotension and heart failure may develop. Nifedin is able to significantly reduce the clearance of digoxin and increase its concentration in the blood. Therefore, the reception of these two funds should be observed. In many cases, a reduction in the dose of digoxin is required.

If you cancel or vice versa, nifedipine, together with quinidine therapy, is recommended to control the amount of the second drug. Dose adjustment in many cases is a forced measure.

The use of nifedipine with rifampicin is strictly prohibited. Because the last drug can accelerate metabolism and weaken the therapeutic effect. Diltiazem significantly reduces the clearance of nifedipine. These two drugs are simultaneously taken with extreme caution. In any case Adalat should be used only with the permission of the doctor.

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Storage conditions

 Adalat standard storage conditions. Any medicinal substance does not like dampness. Therefore, the place in which it will be located must necessarily be warm and dry. It is worth paying attention to the temperature. So, 25 degrees of heat is the norm for the ideal storage of the drug.

The active substance must be protected from exposure to light. It is recommended to remove tablets and capsules from the package only before use. If it is a question of solutions, then similar requirements are put forward to them.

Dampness and direct sunlight are the main enemies of each drug. It is important to follow and external data of medicines. The shells in which the tablets are stored should not be open. This can lead to damage to the drug and its unfitness. It is necessary to avoid overheating the place where the medicine is. All this will preserve the positive qualities of the drug. Adalat is unpretentious, regarding storage conditions, but, despite this, they are worth observing.

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Shelf life

 What can I say about the shelf life of the drug? The main criterion of storage is this indicator. After the expiry date, you can not use the medicine. Adalat can be stored for 5 years and for the whole period does not lose its main positive qualities.

But one period is not enough to preserve the necessary properties of the facility. You must also observe certain storage conditions. So, do not expose the medicine to direct sunlight. They are able to spoil the means. Under the ban is also damp. A damp place should in no case be used for storage.

It is necessary to pay attention to the external data of the preparation. Shells, capsules and containers for infusion should be intact. The slightest damage shortens the shelf life of the drug. Therefore, it is necessary to take this issue seriously.

Proper storage is a pledge of a long life of the drug. Only in this way will it be possible to use the remedy for all 5 years of service. Adalat is a wonderful medicine with good indicators.