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Acnesept
Last reviewed: 03.07.2025

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Acnesept is an antimicrobial medication used to treat acne. It contains the substance clindamycin.
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Indications Acnesept
It is used to treat common acne.
Release form
The medicine is released in the form of a solution for external treatment, in 30 ml bottles. There is 1 such bottle inside the pack.
Pharmacodynamics
Clindamycin is a semi-artificial derivative of lincomycin (an antibiotic obtained from Streptomyces lincolensis). The substance has a bactericidal and bacteriostatic effect, taking into account the zone of influence and sensitivity of bacteria.
Clindamycin inhibits protein binding processes in sensitive microbes by synthesizing with the ribosomal bacterial 50S subunit, interrupting protein binding at an early stage. It has been found that the range of clindamycin activity in in vitro and in vivo tests includes most gram-positive microorganisms, as well as anaerobes and simple microbes. It does not affect viruses with fungi, as well as enterobacteria.
Local treatment of the skin with a 1% solution of clindamycin hydrochloride inhibits the growth of sensitive microbes, especially anaerobes of acne propionibacteria found in follicles with sebaceous glands; in addition, the FFA values inside the sebum decrease. Such a decrease in FFA values occurs due to indirect inhibition of bacteria that produce lipase, which is required for the transformation of triglycerides into FFA, or due to a decrease in the volume of lipase production by microbes.
In addition to lipases, acne propionibacteria produce hyaluronidases with proteases, as well as chemotactic factors, which together with comedogenic fatty acids are responsible for the development of inflammatory processes (cysts, as well as pustules with papules and nodes) in acne. Because of this, to obtain an effect after local treatment with clindamycin in people with acne, both the antibacterial and anti-inflammatory effects are important (a very important process in this case is the suppression of leukocyte chemotaxis).
Pharmacokinetics
It was found that after treatment with the active element of the drug marked with a radioisotope, a specially prepared model of human epidermis in vitro absorbs about 10% of the dosage into the stratum corneum.
Clindamycin penetrates well into inflamed areas when applied locally. Its bioavailability after epidermal treatment is about 7.5%.
Dosing and administration
The solution is applied in a thin layer to the inflamed area of pre-washed epidermis 2 times a day. The duration of the treatment cycle is selected by the physician on an individual basis.
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Use Acnesept during pregnancy
It was determined that with systemic use of the drug in the 2nd and 3rd trimesters, there was no increase in the incidence of congenital developmental anomalies in the fetus.
In the 1st trimester, the medication is used only if there is an obvious need. It is known that no appropriate, adequately controlled tests of Acnecept have been performed in the 1st trimester.
There is no data on whether clindamycin passes into breast milk when the solution is used externally. But there is information on the presence of clindamycin in breast milk when the drug is administered parenterally or internally. Due to the risk of serious complications in infants, it is necessary to stop using the drug or breastfeeding for the duration of therapy (in this case, the mother's need for the solution is taken into account when choosing).
Contraindications
Main contraindications:
- history of severe hypersensitivity to drugs containing lincomycin or clindamycin;
- transmural ileitis;
- ulcerative colitis or colitis caused by the use of antibiotics.
Side effects Acnesept
It has been found that clindamycin, which is applied topically, occasionally causes the appearance of such side effects as diarrhea or bloody diarrhea, as well as colitis (this includes its pseudomembranous form).
There is also information about the occurrence of gastrointestinal dysfunction, abdominal pain, vomiting with nausea, and in addition to this folliculitis caused by gram-negative bacteria, a feeling of burning, irritation, dryness and itching. In addition, there is a contact form of dermatitis, erythema, urticaria, oiliness of the epidermis and a burning sensation in the eyes. Signs of intolerance may also develop.
Parenteral or internal use of clindamycin can cause severe colitis, which can even lead to death.
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Overdose
After local application, clindamycin is able to be absorbed in volumes sufficient to develop systemic effects.
Interactions with other drugs
Clindamycin is able to block the transmission of impulses along nerves and muscles, which is why, when combined with other drugs that have the same effect, this effect is potentiated. Because of this, such a drug combination should be carried out with great caution.
Lincomycin and clindamycin have cross-resistance. In addition, there is an antagonistic interaction between the drug and erythromycin.
Storage conditions
Aknesept should be kept in a place out of reach of small children. Temperature values are within 25°C.
Shelf life
Aknesept can be used within 24 months from the date of manufacture of the pharmaceutical product.
Application for children
There is no information regarding the therapeutic efficacy and safety of the drug when prescribed to children under 12 years of age.
Analogues
Analogues of the drug are Zerkalin, Duak with Zinerit, as well as Dalacin T and Deriva S gel.
Attention!
To simplify the perception of information, this instruction for use of the drug "Acnesept" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.