Acnept

Acnecept is an antimicrobial medication that treats acne. Contains clindamycin.

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Indications Aknesepta

It is used to treat simple acne.

Release form

The drug is produced in the form of a solution for external treatment, in flacons with a volume of 30 ml. Inside of packet 1 such a bottle.

Pharmacodynamics

Clindamycin is a semi-inoculum lincomycin derivative (an antibiotic that is obtained from Streptomyces lincolensis). The substance has a bactericidal and bacteriostatic effect, taking into account the zone of influence and sensitivity of bacteria.

Clindamycin depresses the binding of the protein of sensitive microbes, synthesized with the ribosomal bacterial 50S subunit, interrupting the binding of proteins at an early stage. It was found that the range of clindamycin activity in in vitro tests, as well as in vivo, includes the majority of gram-positive microorganisms, as well as anaerobes and simple microbes. Does not affect viruses with fungi, as well as enterobacteria.

When the skin is treated locally with a 1% solution of clindamycin hydrochloride, growth of sensitive microbes, especially anaerobes of propionibacteria acne, occurs in follicles with sebaceous glands; In addition, the FFA in the sebum decreases. Such a decrease in the values of FFA is due to the indirect inhibition of bacteria producing lipase required for the transformation of triglycerides in FFA, or due to a decrease in the volume of production of lipase by microbes.

In addition to lipases, propionibacteria acne produce hyaluronidases with proteases, as well as chemotactic factors, together with comedogenic SLC responsible for the development of inflammatory processes (cysts, as well as pustules with papules and nodes) for acne. Because of this, in order to obtain an effect after local treatment with clindamycin in people with acne, both antibacterial and anti-inflammatory effects are important (a very important process is suppression of leukocyte chemotaxis).

Pharmacokinetics

It was revealed that after processing of the active element of the drug with the radioisotope noted, a specially made model of human epidermis in vitro absorbs about 10% of the dosage of the stratum corneum.

Clindamycin well penetrates into the inflamed areas during local treatment. The values of its bioavailability after treatment of the epidermis are about 7.5%.

Dosing and administration

A thin layer of the solution is applied to the inflamed zone of the pre-washed epidermis 2 times a day. The duration of the treatment cycle is selected by the physician on an individual basis.

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Use Aknesepta during pregnancy

It was determined that during the systemic use of the drug in the 2nd and 3rd trimesters, there was no increase in the incidence of congenital developmental anomalies in the fetus.

In the first trimester, the medication is used only if there is an obvious need. It is known that the corresponding, adequately controlled tests of Acnecept on the 1st trimester were not performed.

There is no indication as to whether clindamycin passes into mother's milk when the solution is used topically. But there is information about the presence of clindamycin in human milk with parenteral or internal administration of drugs. Due to the fact that there is a risk of serious complications in infants, it is necessary to cancel the use of the drug or breastfeeding for the duration of therapy (in this case, the choice takes into account the need for the mother to use the solution).

Contraindications

The main contraindications:

• presence in the anamnesis of strong sensitivity for preparations containing lincomycin or clindamycin;
• transmural ileitis;
• Ulcerative form of colitis or colitis, which is caused by the use of antibiotics.

Side effects Aknesepta

It was revealed that clindamycin, which is applied externally, occasionally caused the emergence of such side effects as diarrhea or bloody diarrhea, as well as colitis (this includes its pseudomembranous form).

There is also information about the appearance of abnormalities of the function of the gastrointestinal tract, abdominal pain, vomiting with nausea, and besides this folliculitis provoked by gram-negative bacteria, burning, irritation, dryness and itching. In addition, there is a contact form of dermatitis, erythema, urticaria, fatty epidermis and a burning sensation in the eyes. There may also be signs of intolerance.

Parenteral or internal use of clindamycin may provoke the appearance of a severe form of colitis that can even lead to death.

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Overdose

After a local application, clindamycin can be absorbed in volumes that are sufficient for the development of systemic exposure.

Interactions with other drugs

Clindamycin is able to block the transmission of impulses along the nerves and muscles, because of this, when combined with other agents having the same effect, this potentiation of the effect occurs. Because of this, this drug combination should be carried out with great care.

Lincomycin with clindamycin is cross-resistant. In addition, there is an antagonistic interaction between the drug and erythromycin.

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Storage conditions

Acnecept is required to be kept in a place that is closed from access by young children. The temperature is within 25 ° C.

Shelf life

Acnecept can be used within 24 months of the manufacture of the pharmaceutical.

Application for children

There is no information on the therapeutic efficacy and safety of the drug when prescribing to children under 12 years of age.

Analogues

Analogues of the medication are Zerkalin, Duak and Zinerit, as well as Dalatsin T and Deriva C gel.