Abrol

In our time, the following things are very important in the treatment: price and effectiveness. Abrol combines these two qualities, because it has low cost and effective therapeutic functions.

The main feature that distinguishes Abrol is that it quickly eliminates cough of bronchial origin. In addition, contraindications apply only to children up to a certain age, pregnant, nursing mothers and people with increased sensitivity to the components of the drug.

Concerning the profitability of Abrola, one can say that he is among the first among mucolytics.

Indications Abrol

Abrol belongs to a number of mucolytic drugs, the international name Ambroxol.

His therapy is aimed at solving problems associated with acute and chronic bronchopulmonary diseases, which are related to the violation of bronchial secretion and with a decrease in the advancement of mucus. That is, the main zone of the drug struggle with lung and bronchial disease.

Abrol in connection with the functional features effectively eliminates cough and hoarseness and improves breathing. More precise information on the indications depends on the form of its release, which in this case a lot.

[1], [2], [3], [4], [5], [6]

Release form

Abrol has several forms of release: a tablet form and in the form of syrups (1 bottle - 15/5 ml, 2 bottles - 30/5 ml).

The difference between these types of Abrola is not only in the form of release, but also in age restrictions, namely:

• the tablet form is intended for children no younger than 12 years,
• in the form of syrup is allowed to give to children from 1 year.

Of course, the methods of administration, dose and duration of treatment depend on the form of release of this drug. The action of all species of Abrola is the same, that is, expectorant.

[7], [8]

Pharmacodynamics

Abrol is a mucosal agent, where the main feature is the expectorant effect.

Its action is directed to the withdrawal and elimination of sputum by activating the activity of serous gland cells located on the mucous membrane of the bronchi, while the mucus and serous sputum enzyme is regenerated. Thanks to a drug such as Abrol, the body recovers the production of components that split the binding of mucopolysaccharides in sputum. The resumption of rheological functions of sputum is carried out under the influence of Abrol on the formation of a surfactant, during which the viscosity of sputum decreases, and its adhesion to the bronchial mucosa decreases. The medication acts as an activating agent on the ciliated epithelium, and as a result, the evacuation function increases. With active movement of cilia, adhesion of the bronchi decreases, which promotes mucociliary stroke.

Abrol has a local anesthetic and a weak antitussive effect. In addition, the effect on the metabolism of arachidonic acid, the oxidation in the area of inflammation is free. And it also enhances the effect of antibacterial drugs.

[9], [10], [11]

Pharmacokinetics

Abrol is rapidly excreted from the digestive system. With max it appears in the blood after 1 to 3 hours. The agent appears in the associated position with albumin almost 90%. Metabolism is carried out in the liver, during which glucuronization occurs metabolite. CYP3A4 exerts control over the metabolism of Abrol to dibromantranilic acid. The elimination half-life ranges from 10 to 12 hours. The free form of the drug reaches 6%, 26% is the amount of form of conjugates in the urine. In the case of HNP, the concentration of Abrol increases, which causes the growth of its content in the blood plasma in 3 or even more times. Abrol is excreted in the urine, partly with feces.

[12], [13], [14], [15]

Dosing and administration

Abrol is used, regardless of the form of its release, exclusively by the oral route, as well as during or after a meal. More specific information is divided into 3 categories, based on the type of release of the drug:

• tablet form of Abrola (from 12 years): 1 tablet three times a day. A faster effect is achieved with this dosage: 2 tablets twice a day. Duration of treatment 4 - 14 days,
• syrup (15/5 ml):
  • children from one year to two years: 2.5 ml twice a day,
  • from 2 to 6 years: 2.5 ml three times a day,
  • from 6 to 12 years: 5 ml is divided into 2 or 3 doses per day.

The period of application is up to 14 days,

• syrup (30/5) children with 12 years and adults should take Abrol 2 times a day, where the daily rate of 10 ml. After 2 weeks, the dose is halved.

[23], [24], [25], [26]

Use Abrol during pregnancy

Abrolus, despite its many advantages, still has some drawbacks, and they have to do with the effect on the fetus. Can I take it during pregnancy? Yes, but only in the second and third trimester of pregnancy, and then, if, in the opinion of the doctor, the benefit provided by the drug exceeds the possible risk. As for the first trimester, in medicine there is not enough information about the influence of Abrol components on the health of the child during this period of pregnancy.

Abrolol is undesirable to take not only during pregnancy, but also during the period of feeding, as this drug enters the mother's milk. So, during the period of taking the drug, breastfeeding should be stopped.

Contraindications

Reception of Abrola during pregnancy and lactation, we discussed somewhat higher. Also, Abrol should not be taken with:

• hypersensitivity to the components of the drug.

If the form of release of Abrola syrup, it is impossible to use:

• as a result of intolerance to fructose,
• in the case of severe renal dysfunction,
• if the child's age does not reach 12 months.

The tablet form of Abrola or in the form of a syrup of 30 mg / 5 ml for children under 12 years of age is contraindicated.

In any case, before buying any medication, you should consult a doctor.

[16], [17], [18], [19], [20]

Side effects Abrol

Usually Abrol is well tolerated. But again, everything depends on the individual characteristics of the organism. In addition, side effects are an extreme rarity, which include:

• an allergic reaction similar to hives,
• skin itching or other changes from the side of dermatology,
• changes in taste,
• dyspeptic manifestations,
• disorders of stool,
• a feeling of dryness in the throat and in the mouth.

In case of skin allergic reactions, use of Abrol should be stopped immediately and consult with a doctor. It is possible (or rather more than likely) that the patient has an allergy to the substances that make up Abrola.

[21], [22],

Overdose

Data on overdose were not recorded. If Abrol is used according to the recommendations specified in the instructions, then an overdose is not possible as it is established by the doctors and developers of the drug.

If, during or after taking the drug, any negative symptoms occur, then symptomatic therapy is performed. As a result of the appearance of various symptoms, usually allergic reactions to these or other components of the drug are detected. But, anyway, it is necessary to consult a doctor, since cases of overdose in medical practice have not been met.

[27]

Interactions with other drugs

Naturally, the doctor who prescribes complex treatment, selects medicines in accordance with their therapeutic functions, chemical characteristics. Namely:

• Abrol strengthens the secretion of the bronchial system:
  • erythromycin,
  • cefuroxime,
  • amoxicillin.
• Abrol is absolutely not combined with other means designed to eliminate cough, as the functioning of mucociliary transport in an environment where the production of mucus is significantly increased, which causes stagnation inside the pulmonary tree, is destroyed.

[28], [29], [30]

Storage conditions

The tableted form and syrup possesses the standard storage conditions:

• dry place,
• absence of light,
• the air temperature should not exceed 25 ° C.

Abrol should be hidden from children's hands.

The preparation itself should be stored in its original packaging with the attached instructions as follows:

• on the package the date of manufacture and the period of storage of the preparation are indicated,
• in the case of the loss of instructions, the methods of application of Abrola will have to be learned in other ways (for example, on the Internet),
• on tableted forms, more precisely on the plate itself, the inscriptions become less prominent with time, and sometimes it is impossible to determine the name of the drug.

[31], [32], [33]

Shelf life

Abrol with proper storage is suitable for 2 years. In the case of opening the bottle (if the form of the release is a syrup), the shelf life of the drug is reduced to 28 days, as the bubble no longer possesses the necessary tightness when closing, as a result of which the active components of the drug lose their therapeutic properties. From which it follows that at the end of 28 days the use of Abrola does not make sense. If the medication is overdue, then it should be discarded.

[34]