Dufalak

Duphalac (lactulose) is a medicine used to treat constipation. Lactulose is an original synthetic disaccharide that is not absorbed in the intestine, but has an osmotic effect, increasing the volume and improving the consistency of stool. It also stimulates the growth of beneficial intestinal microflora, which helps restore natural intestinal motility and improve its functions.

Indications Dufalaka

1. Treatment and prevention of constipation.
2. Correction of stool disorders in patients with various intestinal diseases.
3. Preparation for examinations and operations on the intestines.
4. Complex therapy of hepatic encephalopathy (including with the aim of reducing ammonium salts in the intestines).
5. Regulation of intestinal microflora.
6. Prevention and treatment of dysbiosis and intestinal infections.
7. Other conditions associated with impaired intestinal motility and stool.

Release form

Duphalac is available in syrup form.

Pharmacodynamics

Lactulose, the main active ingredient in Duphalac, is an organic compound that is not absorbed in the human gastrointestinal tract. It passes through the intestines almost unchanged and has a laxative effect, increasing the volume of stool and improving its consistency. Lactulose also increases acidity in the intestines, which creates unfavorable conditions for the reproduction and activity of pathogenic microorganisms. This helps restore normal intestinal flora.

Pharmacokinetics

Lactulose is not usually absorbed from the human digestive tract. Instead, it passes through the intestines virtually unchanged. In the colon, lactulose is metabolized by bacteria present in the intestine into organic acids, including lactic and acetic acid, and into gases. This process leads to a change in the acidity of the intestinal contents and stimulates intestinal motility, which helps regulate intestinal functions and facilitate bowel movements.

Dosing and administration

1. Constipation: For the treatment of constipation in adults, an initial dose of 15 ml to 30 ml of lactulose once or twice a day is usually prescribed. If necessary, the dose can be increased. For children, the dosage is determined individually depending on age and weight.
2. Maintain gut health: To maintain gut health and prevent constipation, it is usually recommended to take 15 ml to 30 ml of lactulose once a day.
3. Powder or syrup: Lactulose is available in the form of syrup or powder for solution. The dosage may be indicated on the package, but it is always best to consult your doctor for exact dosage recommendations.
4. Duration of use: The duration of use of lactulose may also vary depending on the medical condition. Typically, treatment is carried out until the desired effect is achieved, after which the dosage may be reduced or discontinued.

Use Dufalaka during pregnancy

During pregnancy, the use of lactulose is generally considered relatively safe. However, as with any drug, before starting to use lactulose during pregnancy, it is important to consult with your doctor or obstetrician.

Contraindications

1. Individual intolerance or allergic reaction to lactulose or other components of the drug.
2. Increased risk of intestinal obstruction or peritonitis.
3. Galactosemia (disorder of galactose metabolism) or lactase deficiency (lack of lactase enzyme).
4. Severe disturbances of water and electrolyte balance.
5. Diabetes mellitus (when using medications containing sugar).

Side effects Dufalaka

1. Gas and Bloating: Lactulose may promote the formation of gas in the intestines, which can cause gas and bloating.
2. Diarrhea: Excessive consumption of lactulose can lead to diarrhea.
3. Vomiting or nausea: Some people may experience vomiting or nausea as a result of consuming lactulose.
4. Confusion or drowsiness: Although rare, some people may experience confusion or drowsiness when consuming lactulose.
5. Electrolyte disturbances: Long-term use of lactulose may cause electrolyte disturbances, such as loss of potassium or sodium.

Overdose

Overdose of lactulose is usually unlikely due to its low toxicity and lack of systemic absorption from the gastrointestinal tract. However, if you exceed the recommended dose, side effects may occur, such as abdominal pain, bloating, diarrhea, or an unwanted increase in gas in the intestines.

Interactions with other drugs

Duphalac usually does not interact with other drugs due to its nature and low systemic absorption.