Dormiplant

Dormiplant is a combined herbal preparation designed to improve sleep and calm the nervous system. It contains two main active ingredients: dry extract of rhizomes with valerian roots and dry extract of lemon balm leaves. Both of these components are known for their calming and sedative properties.

Main components and their actions:

1. Dry extract of rhizomes with valerian roots:

   • Valerian (Valeriana officinalis) is one of the most famous remedies for combating insomnia and nervous agitation. It has a calming effect on the central nervous system, helps reduce the time it takes to fall asleep and improve sleep quality.

2. Dry extract of lemon balm leaves:

   • Melissa (Melissa officinalis) – used to reduce stress, anxiety and nervous tension. Melissa also has a mild antispasmodic effect, which can contribute to overall relaxation of the body and improved sleep.

Indications Dormiplanta

1. Insomnia: Difficulty falling asleep, frequent awakenings and restless sleep.
2. Increased nervous excitability: Conditions accompanied by anxiety, irritability and stress.
3. Anxiety and restlessness: Help with nervous disorders and stressful situations.

Release form

Dormiplant is available in the form of film-coated tablets.

Pharmacodynamics

1. Dry extract of rhizomes with valerian roots

Mechanism of action: Valerian contains several active components, including valerenic acids and valeriopolysaccharides, which have anxiolytic (anti-anxiety) and sedative (soporific) effects. They affect the central nervous system by increasing the activity of inhibitory neurotransmitters such as gamma-aminobutyric acid (GABA), which helps reduce anxiety and improve sleep.

Effects:

• Improving sleep quality
• Reducing anxiety and nervous tension
• Mitigating symptoms of stress and nervousness

2. Dry extract of lemon balm leaves

Mechanism of action: Melissa, or lemon balm, also contains a number of active components, including essential oils, terpenes and flavonoids. It has anxiolytic, sedative and antispasmodic effects. Melissa essential oils, including citral and citronellal, have beneficial effects on the central nervous system, reducing anxiety and promoting muscle relaxation.

Effects:

• Improving your mood
• Reduced anxiety and irritability
• Improving sleep quality

Synergetic action

The combination of valerian and lemon balm extracts in Dormiplant allows you to enhance their sedative and anxiolytic effects due to synergy. This means that the effects of each component are enhanced when used together, making the drug more effective in improving sleep and easing nervous tension.

Pharmacokinetics

1. Dry extract of rhizomes with valerian roots:

   • Absorption: Valerian extract is usually taken orally and absorbed through the gastrointestinal tract. It may be poorly absorbed or not completely absorbed.
   • Distribution: Valerian substances absorbed into the body can be evenly distributed throughout the tissues.
   • Metabolism and excretion: Metabolism of valerian occurs in the liver. The main metabolites are glucuronides and sulfates. They are excreted from the body primarily through the kidneys.

2. Dry extract of lemon balm leaves:

   • Absorption: Melissa extract is also taken orally. Its components may be better absorbed than valerian.
   • Distribution: After absorption, lemon balm components can be evenly distributed throughout the body tissues.
   • Metabolism and excretion: Metabolism of lemon balm also occurs in the liver, and metabolites are excreted from the body through the kidneys.

Dosing and administration

Method of application:

• Tablets are intended for oral administration.
• The tablet should be swallowed whole with plenty of water, without chewing.

Dosage:

• Adults and children over 12 years of age are recommended to take 2 tablets 2 times a day.
• If necessary, to improve sleep, you can take 2 tablets half an hour before bedtime.

Use Dormiplanta during pregnancy

The use of herbal remedies, including Dormiplant, during pregnancy requires caution. There is insufficient scientific evidence of the safety of such products for pregnant women, which raises concerns, especially regarding their teratogenic effects.

1. Lack of regulation and potential risks: Herbal products, such as those containing valerian and lemon balm, are often perceived as safe because they are natural, but they may contain substances that may be harmful during pregnancy. There are no strong regulations to control their sale, and they may cause teratogenic or abortifacient effects, making them risky for pregnant women (Bernstein et al., 2020).
2. Limited data on safety and effectiveness: Research generally suggests that some herbs, such as ginger, have been studied and found to be relatively safe in controlled doses, but the effectiveness and safety of many other herbal medicines, including those found in Dormiplante has not been sufficiently supported by scientific research. Pregnant women often use these products without consulting a doctor, which can lead to unexpected complications (Sarecka-Hujar & Szulc-Musioł, 2022).
3. Use of Herbs During Pregnancy: A significant number of pregnant women report using herbal remedies to treat common pregnancy-related problems, often without consulting a health care professional. Self-medication poses risks due to the unknown effects of many herbs on pregnancy and fetal development (Holst et al., 2009).

Although herbal medicines such as Dormiplant are often used during pregnancy, they should be used with caution and under medical supervision. Pregnant women should consult a physician to discuss the use of any herbal remedies to avoid potential risks to their health and the health of their unborn child.

Contraindications

1. Allergy to components of the drug: People with a known hypersensitivity or allergy to any of the components of Dormiplant (valerian, lemon balm) should avoid its use.
2. Pregnancy and breastfeeding: The safety of using Dormiplant during pregnancy and breastfeeding has not been established, so its use in these cases should be agreed with a doctor.
3. Children: The use of Dormiplant in children under 12 years of age is generally not recommended without prior consultation with a doctor.
4. Liver problems: People with severe liver dysfunction should use Dormiplant with caution and under the supervision of a doctor.
5. Alcohol problems: Since Dormiplant contains alcohol (usually in the form of a preservative), it may not be suitable for people with alcohol dependence or those who are advised not to drink alcohol for medical reasons.
6. Use of other medications: Some drug interactions may occur when Dormiplant is used simultaneously with other drugs, so it is important to inform your doctor about all the medications you are taking. Medicines.

Side effects Dormiplanta

1. Drowsiness: Especially at the beginning of treatment or when the dose is increased.
2. Dizziness: May affect some people.
3. Stomach upset: Including stomach discomfort, nausea or vomiting.
4. Allergic reactions: Hives, itching, swelling or even anaphylactic shock in rare cases.

Overdose

• Extreme drowsiness or general weakness
• Dizziness
• Low blood pressure (hypotension)
• Respiratory depression
• Reduced response to external stimuli
• Stomach upsets (nausea, vomiting, diarrhea)
• Potentially increased side effects such as dry mouth or fatigue

Interactions with other drugs

1. Hypnotics and sleep-inducing drugs: Taking Dormiplant in combination with other hypnotic drugs, such as benzodiazepines or hypnotics, may increase the sedative effect. This can lead to excessive decrease in wakefulness and lethargy.
2. Central-acting drugs: Additional drugs that affect the central nervous system, such as antidepressants, antipsychotics or analgesics, may increase the sedative effect of Dormiplant.
3. Drugs affecting mental status: Use of Dormiplant with drugs such as barbiturates or antiepileptic drugs may increase or alter the effects on mental status.
4. Alcohol: Drinking alcohol together with Dormiplant may increase its sedative effect and increase the risk of side effects such as dizziness, lethargy and drowsiness.
5. Drugs that increase bleeding: Valerian may have a minor effect on prothrombin levels in the blood, so using Dormiplant with anticoagulants or antiplatelet agents may increase the risk of bleeding.