Wobenzym

Wobenzym is a combination drug containing a mixture of enzymes such as pancreatin, papain, rutoside trihydrate, bromelain, trypsin, lipase, amylase and chymotrypsin. These enzymes are usually present in the human body and are involved in the digestion process.

Here is a brief description of each component:

1. Pancreatin: This is a mixture of enzymes produced by the pancreas, including amylase, lipase and proteases, which help break down carbohydrates, fats and proteins in food for absorption by the body.
2. Papain and bromelain: These are enzymes derived from papaya and pineapple, respectively, that also help break down proteins in food.
3. Trypsin and chymotrypsin: These are enzymes produced by the pancreas that are also involved in the breakdown of proteins in food.
4. Lipase and amylase: These are enzymes that are also produced by the pancreas and are involved in the breakdown of fats and carbohydrates, respectively.

Wobenzym is commonly used medicinally to support digestion, especially in patients with digestive disorders or gastrointestinal problems. It can be used in the treatment of dyspepsia, pancreatitis, gastritis and other digestive disorders.

The dosage and regimen of Wobenzym may vary depending on the specific indications and doctor’s recommendations.

Indications Wobenzyma

1. Digestive disorders: The drug may be used for digestive disorders, including dyspepsia (indigestion), diarrhea, constipation or flatulence (bloating).
2. Chronic pancreatitis: In cases of chronic inflammation of the pancreas, Wobenzym may help improve digestion and reduce symptoms associated with this condition.
3. Gastrointestinal Support: The drug may be used to relieve symptoms associated with various gastrointestinal diseases, such as gastritis, peptic ulcers, or colitis.
4. Improving nutrient absorption: Wobenzym can be used to increase the absorption of nutrients from food in patients with digestive disorders.
5. Diet Support: In some cases, the drug may be used as a dietary supplement to improve digestion and relieve symptoms associated with selective or restrictive eating.

Release form

Wobenzym is usually available in the form of tablets or capsules for oral administration.

Pharmacodynamics

1. Pancreatin: Pancreatin is a complex of enzymes including amylase, lipase and proteases. It is used to support digestion by breaking down carbohydrates, fats and proteins in the intestines and helping the body absorb nutrients from food.
2. Papain and Bromelain: These are proteolytic enzymes extracted from papaya and pineapple respectively. They help break down proteins in food, improving digestion and relieving some symptoms associated with digestive disorders.
3. Trypsin, chymotrypsin and other proteases: These enzymes also help break down proteins in food, ensuring normal digestion and improving protein absorption.
4. Amylase: This enzyme breaks down carbohydrates (amyls) in food into simple sugars such as glucose, making carbohydrates easier to digest and absorb.
5. Lipase: Lipase breaks down fats in food into fatty acids and glycerol, which allows the body to absorb them.

Pharmacokinetics

1. Absorption: Most of these components are normally broken down and absorbed in the small intestine. Some of them may be absorbed into the blood, especially if enzymes are present in the preparation.
2. Distribution: After absorption, the active components can be distributed to organs and tissues.
3. Metabolism: Most of these components can undergo metabolic transformations in the liver or other organs.
4. Excretion: Metabolites or unchanged components may be excreted in urine or through bile salts.

Dosing and administration

Method of application:

1. Oral administration:
   • Wobenzym tablets should be taken orally, 30 minutes before meals, with a sufficient amount of liquid.
   • The tablets must be swallowed whole, without chewing, so that the active components can reach the small intestine, where they are most effective.

Dosage:

1. Adults:

   • The usual starting dosage is 3 tablets 3 times a day.
   • Depending on individual reaction and symptoms, the dosage can be increased to 5 tablets 3 times a day.
   • Once improvement is noticeable, the dose can be gradually reduced to a maintenance dose, for example, to 2 tablets 3 times a day.

2. Children:

   • Wobenzym should be used in children only as directed and under the supervision of a physician, especially given the complexity and variety of enzymes in the composition.

Duration of treatment:

• The duration of treatment with Wobenzym depends on the nature and severity of the disease, as well as on the individual response to treatment. In some cases, long-term use may be required, especially for chronic conditions.

Use Wobenzyma during pregnancy

The use of Wobenzym or any other enzyme preparations during pregnancy requires careful consideration and consultation with your doctor. Here are some important points to consider:

1. Lack of data:

   • Scientific data on the safety of using Wobenzym during pregnancy is insufficient. Most studies were conducted on animals, and it is not clear whether the results can be extrapolated to humans.

2. Potential risks:

   • Certain components, such as papain and bromelain, may increase the risk of bleeding, which is especially dangerous during pregnancy and childbirth.
   • Enzymes such as trypsin and chymotrypsin can affect the immune system and inflammatory processes, which could theoretically affect fetal development or pregnancy.

3. Consultation with a doctor:

   • Before taking Wobenzym during pregnancy, be sure to consult your doctor. Your doctor will be able to evaluate your individual condition, consider the risks and benefits, and make an informed decision.

4. Alternatives:

   • Your doctor may suggest other, safer methods for managing inflammation and digestion during pregnancy that do not involve risks to the developing fetus.

Contraindications

1. Individual intolerance: People with a known individual intolerance to any of the components of Wobenzym should avoid its use.
2. Acute inflammatory diseases of the digestive system: The use of Wobenzym may be contraindicated in patients with acute inflammatory diseases of the digestive system, such as acute pancreatitis or acute cholecystitis, due to the risk of increased inflammation.
3. Allergic reactions to enzymes: In patients with a history of allergic reactions to enzymes such as papain, bromelain or trypsin, the use of Wobenzym may be contraindicated.
4. Acute or subacute conditions of the digestive system: The use of Wobenzym may be contraindicated in patients with acute or subacute conditions of the digestive system, such as gastric ulcers or ulcerative colitis, due to the risk of increased symptoms and complications.
5. Pregnancy and breastfeeding: The safety of using Wobenzym during pregnancy and breastfeeding has not been established, so its use during these periods may be contraindicated without consulting a doctor.
6. Childhood: The use of Wobenzym in children and adolescents may be limited due to limited data on efficacy and safety in this age group.

Side effects Wobenzyma

1. Allergic Reactions: Some ingredients, such as papain and bromelain, may cause allergies, especially in people with allergies to tropical fruits or latex. Symptoms may include rash, itching, swelling and, in rare cases, anaphylactic shock.
2. Gastrointestinal disorders: Such as diarrhea, nausea, vomiting and abdominal pain. These symptoms may occur due to the activity of enzymes that irritate the gastrointestinal tract.
3. Changes in digestion: Due to the content of digestive enzymes such as lipase, amylase and pancreatin, changes in stool and abdominal discomfort may occur.
4. Headaches and dizziness: Some users report headaches and dizziness while taking the drug, although these symptoms may not be directly related to the enzymes.

Overdose

The consequences of overdose may include an increase in unwanted drug-related side effects, such as diarrhea, nausea, vomiting, allergic reactions and gastrointestinal disorders.

Interactions with other drugs

1. Antagonism with anticoagulants: Components such as bromelain and papain may enhance the effects of anticoagulants, which may lead to an increased risk of bleeding.
2. Interactions with antibiotics: Interactions with some antibiotics are possible, especially those that act in the intestines. This may lead to a decrease in the effectiveness of antibiotics.
3. Increasing the effect of drugs that affect digestion: Since Wobenzym contains digestive enzymes, its simultaneous use with other drugs that affect digestion can lead to an increase in their effect.
4. Interaction with antihypertensive drugs: The effect of antihypertensive drugs may be enhanced when used together with Wobenzym.
5. Effect on the absorption of other medications: Because Wobenzym may affect the digestion and absorption of food, it may also affect the absorption of other medications.