Anesthesol

"Anestezol" is a medication that is commonly used to relieve pain and irritation in the rectal area. It is presented in the form of rectal suppositories and contains several active components:

1. Benzocaine: This is a topical anesthetic that is commonly used for temporary relief of pain and itching.
2. Bismuth subgallate: This is a substance that has antiseptic and constrictive properties. It can help reduce inflammation and irritation in the rectal area.
3. Zinc oxide: This is a component that has anti-inflammatory and antiseptic properties. It also promotes tissue healing.
4. Menthol: This is a topical irritant that can provide a cooling sensation and soothe itching and irritation.

Usually "Anestezol" is used to treat hemorrhoids, anal fissures, proctitis and other conditions associated with irritation and pain in the rectal area. However, the use of this drug should be under the supervision of a doctor, as it can have side effects and contraindications, especially with prolonged use.

Indications Anesthesola

1. Hemorrhoids: Anestezol may be used to relieve pain, itching and discomfort associated with inflamed or thrombosed hemorrhoidal nodes.
2. Anal fissures: The product can be used to soothe the pain and irritation that can occur with anal fissures.
3. Proctitis: Anestezol may help relieve the discomfort and pain of inflammation of the rectum.
4. Postoperative analgesia: The use of Anesthesol may be recommended after rectal surgery to relieve pain and discomfort in the postoperative period.
5. Other conditions associated with pain and irritation in the rect alarea: This medication may be used in other cases of pain, itching, or irritation in the rectal area.

Release form

Rectal suppositories (rectal suppositories): This is the main and only form of Anestezol, which makes its use specifically targeted at the treatment of anal problems. The suppositories are designed to be inserted into the rectum, which provides local anesthetic, healing and antiseptic action.

Pharmacodynamics

1. Benzocaine: It is a local anesthetic that blocks the conduction of nerve impulses, resulting in temporary analgesia in the area of application. In rectal suppositories, benzocaine may provide an analgesic effect in contact with the rectal mucosa.
2. Bismuth subgallate: This ingredient has astringent and antiseptic effects. It can help shrink mucous membranes and reduce irritation in the rectal area, as well as protect it from infections.
3. Zinc oxide: Zinc oxide has anti-inflammatory and antiseptic properties. It may help reduce inflammation and irritation of the rectal mucosa.
4. Menthol: Menthol has a cooling and analgesic effect. It can help relieve discomfort and itching in the anorectal area and also has a mild antiseptic effect.

Pharmacokinetics

1. Absorption: Since Anestezol is used in the form of rectal suppositories, its components may be absorbed through the rectal mucosa. However, absorption may not be very high because the drug is usually applied topically and does not pass through the digestive tract.
2. Distribution: After absorption, the active ingredients may be distributed in the tissues of the rectum and neighboring organs.
3. Metabolism: Information on the metabolism of the components of Anesthesol is not widely known, but in general many of them may be subject to metabolism in the liver or other tissues.
4. Excretion: Metabolites or unchanged components may be excreted through the kidneys or bile.
5. Excretionhalf-life: The half-life of active ingredients may vary depending on their characteristics and route of administration.

Dosing and administration

Method of Application:

1. Before use, clean the anus area gently to avoid additional irritation. Wet wipes or warm water with mild soap can be used.

2. Suppository insertion:

   • Wash your hands before opening the suppository package.
   • The suppository may be moistened with water to facilitate insertion.
   • Lie on one side with your knees pulled up to your chest (fetal position).
   • Gently insert the suppository with the pointed end forward into the anus.
   • Push the suppository as deep into the rectum as possible.
   • After inserting the suppository, stay lying on your side for a few minutes to prevent the medicine from leaking out.

3. Wash your hands againafter application.

Dosage:

• Adults and children over 12 years of age:
  • It is usually recommended to administer one suppository 1-2 times a day (morning and evening).
  • The duration of treatment depends on symptoms and doctor's recommendations, but usually does not exceed 7-10 days.

Special Instructions:

• Do not use Anestezol for longer than the recommended period without consulting your doctor.
• Anestezolol may cause local irritation, burning or increased pain, especially in the presence of fissures or erosions in the anal area.
• In case of allergic reactions (such as rashes, itching, swelling), discontinue use and consult a physician.
• Use the drug with caution in the presence of serious forms of hemorrhoids, especially accompanied by bleeding.

Use Anesthesola during pregnancy

The use of such drugs during pregnancy requires special caution and mandatory agreement with a doctor.

Benzocaine is a local anesthetic and may penetrate the placental barrier, so its use during pregnancy may not be safe. Bismuth subgallate and zinc oxide are generally considered safe for use during pregnancy for external use, but also require medical advice. Menthol may cause irritation of the skin or mucous membranes and may not be safe for internal use during pregnancy.

Contraindications

1. Hypersensitivity: People with known hypersensitivity to any of the components of the drug should avoid its use.
2. Skin and mucous membraneinjuries: Use of the drug should be avoided in case of skin and mucous membrane injuries such as ulcers, fissures or inflammation, as this may cause additional irritations or complications.
3. Pediatric: The use of Anesthesol in children, especially infants, may be undesirable without medical advice.
4. Pregnancy and lactation: Safety of the drug use during pregnancy and lactation has not been established. A doctor should be consulted before using Anestezol in these cases.
5. Liver and kidneys: Use of the drug may require caution in patients with impaired liver and kidney function.

Side effects Anesthesola

1. Allergic Reactions: Any of the ingredients of the product, including benzocaine, bismuth subgallate, zinc oxide or menthol, may cause an allergic reaction in some patients, manifested as skin rash, itching, swelling or even anaphylactic shock.
2. Irritationor burning in the rectalarea: The use of menthol and benzocaine may cause irritation or burning in the rectal area in some patients.
3. Reactions to bismuth subgallate: In some cases, bismuth may cause a change in stool color to black (feces may become black), which is a normal reaction to taking this substance, but sometimes it may also cause undesirable effects such as nausea, vomiting and constipation.
4. Undesirable effects of benzocaine: This local anesthetic can cause various unwanted effects such as dizziness, nausea, vomiting, drowsiness, allergic reactions, arrhythmias or even anaphylactic shock if used excessively internally.
5. Zinc oxide side effects: This substance may cause skin irritation as well as rare allergic reactions.
6. Possible effects of menthol: M enthol use may cause a cooling or burning sensation in the rectum and rare allergic reactions.

Overdose

Information about overdose of Anesthesol rectal suppositories is limited, because the drug is usually used topically and in small doses. However, some undesirable effects may occur if too many suppositories are used or if the dose is increased above the recommended dosage.

Potential consequences of overdose may include an increase in side effects associated with each component of the drug. For example, benzocaine overdose can lead to allergic reactions, decreased muscle tone, and even serious allergic reactions including anaphylaxis. Menthol overdose can cause irritation of mucous membranes and skin, body cooling, and allergic reactions.

Interactions with other drugs

1. Other local anesthetics: The use of Anesthesol with other local anesthetics may enhance its analgesic effect. However, it may also increase the risk of side effects such as allergic reactions or skin irritation.
2. Preparations containing bismuth: Interaction with other preparations containing bismuth may increase its effect on the rectal mucosa. This may result in increased antibacterial and anti-inflammatory action.
3. Preparations containing zinc: The use of Anesthesol with other preparations containing zinc may increase its antiseptic and anti-inflammatory effect.
4. Menthol-containing preparations: The use of Anesthesol with other menthol-containing preparations may increase its cooling and analgesic effect.