Stomatidine

Stomatidine (hexetidine) is an antiseptic agent that is widely used to prevent and treat infections in the mouth and throat. Here is some information about it:

1. Mechanism of Action: Hexethidine has antimicrobial properties and acts as an antiseptic. It kills bacteria, fungi and viruses by disrupting the integrity of the cell membranes of microorganisms.
2. Use: Stomatidine is used for the prevention and treatment of diseases of the mouth and throat, such as stomatitis, gingivitis, pharyngitis, tonsillitis, periodontitis and other infections.
3. Dosageforms: The drug is available as a solution for mouthwash or as a spray for throat treatment. The solution is usually diluted with water before use.
4. Contraindications: Stomatidine is not recommended for people with a known allergy to hexetidine or other components of the drug.
5. Side effects: In rare cases, unpleasant sensations such as burning or tingling at the application site may occur. A temporary change in taste may also occur. If these effects persist or worsen, discontinue use and consult a doctor.
6. Notes: Stomatidine is usually used several times a day for a specific period of time as recommended by your doctor or as directed in the directions for use. You should consult your doctor before use, especially if you have any medical problems or medications you are taking.

Indications Stomatidine

1. Prevention and treatment of oral infections: Stomatidine may be recommended for the prevention and treatment of various oral infections such as stomatitis, gingivitis (inflammation of the gums), periodontitis (inflammation of the periodontium), pharyngitis (inflammation of the back of the throat) and tonsillitis (inflammation of the tonsils).
2. Throat treatment: The drug may be used to treat throat infections such as pharyngitis and tonsillitis.
3. Prophylaxis after surgical interventions: Stomatidine may be recommended as an agent for the prevention of infections after dental or oral surgery.
4. Prevention of tooth decay: In some cases, the drug may be used to prevent tooth decay.
5. Eliminating bad breath: Hexatidine has the ability to reduce the amount of bacteria in the mouth, which can help manage bad breath.

Release form

1. Mouthwash

• Concentration: Hexethidine is standardized at a concentration of 0.1%.
• Packaging: The solution is usually packaged in plastic or glass bottles, often with a dispensing device or cap that can be used to measure the dose. Package size can vary, but volumes of 200 ml or 400 ml are common.

Pharmacodynamics

Stomatidine contains the active substance hexetidine, which has antiseptic and antimicrobial action. Hexetidine is a cationic antiseptic, which forms complexes with negatively charged components of bacterial cells, disrupting their integrity. This leads to disruption of membrane permeability, coagulation of proteins and ultimately to the death of bacteria.

Stomatidine is mainly used to treat infections of the mouth and throat such as stomatitis, gingivitis, pharyngitis and others. Its antimicrobial action helps to reduce the number of bacteria in the affected area, which helps to reduce inflammation and symptoms of infection.

Pharmacokinetics

1. Absorption: After topical application, hexetidine is slowly absorbed through the mucous membrane of the mouth and throat. Most of the drug remains at the site of application and does not enter the systemic bloodstream.
2. Distribution: Hexetidine has low affinity to plasma proteins and is distributed in tissues of the oral cavity and throat.
3. Metabolism: Metabolism of hexethidine in the body is minimal.
4. Excretion: The majority of hexetidine is excreted through the digestive tract. Minimal amounts may be excreted unchanged through the kidneys.
5. Excretion: Thehalf-life of hexetidine varies but is usually about a few hours.

Dosing and administration

Method of Application:

• Mouthwash solution: Stomatidine is intended for external use only. The solution should not be swallowed.
• Ensure that the oral cavity is cleanbefore use. Preferably use Stomatidine after brushing teeth for maximum effectiveness.
• Rinse: Use the measuring cap to measure the exact dose of solution, if provided with the bottle.

Dosage:

• Adults and children over 12 years of age: It is generally recommended to use 10-15 ml of solution for one rinse. Rinse the mouth for about 30 seconds, then spit out the solution. Repeat the procedure twice a day - morning and evening.
• Children under 12 years of age: The use of Stomatidine for children under 12 years of age should only take place under the supervision of a physician, taking into account the possible need for dose adjustment.

Supplemental Guidelines:

• Do not eat or drink for 30 minutes after using Stomatidine to allow the active ingredient to take effect.
• If symptoms persist for more than a few days after starting to use Stomatidine, you should consult a doctor.
• Avoid contact with eyes; in case of accidental contact, flush eyes with plenty of water.

Use Stomatidine during pregnancy

Stomatidine is generally not recommended for use during pregnancy without medical advice. There is limited data on the safety of using this medicine during pregnancy, and therefore it should be taken only for medical reasons and under the supervision of a doctor. The doctor may decide to prescribe Stomatidine if the benefit to the mother exceeds the potential risk to the fetus.

Contraindications

1. Hypersensitivity: People with known hypersensitivity to hexethidine or other ingredients of the drug should not use it.
2. Children under 12 years of age: Some forms of hexetidine, including mouthwash solutions, may be contraindicated for children under 12 years of age due to insufficient efficacy and safety data.
3. In the presence of wounds and lesions of the mucous membrane: Hexetidine may cause irritation, therefore its use may be contraindicated in the presence of open wounds and lesions of the oral mucosa.
4. Health problems: Before using Hexatidine, you should discuss with your doctor if you have other medical problems such as pregnancy, breast-feeding, allergies, heart disease, or liver or kidney problems.
5. Pediatric population: Age restrictions and contraindications may apply to children depending on age and health status.

Side effects Stomatidine

1. Burningor tingling sensationin the mouth: Some people may experience a burning or tingling sensation at the application site. This is usually minor and temporary.
2. Change in taste: After using Stomatidine, some people may temporarily experience changes in the taste of food or liquids.
3. Dry mouth: Some patients may experience a dry mouth sensation after using the drug.
4. Redness or irritation of the gums: Some people may experience redness or mild irritation of the gums after using Stomatidine.
5. Allergic reactions: In rare cases of Stomatidine use, allergic reactions such as skin rash, itching, swelling of the throat or face may occur.
6. Other rare effects: Other adverse reactions, including headache, nausea or vomiting, may occur in isolated cases.

Overdose

Stomatidine (hexetidine) overdose is unlikely to occur with normal use. However, if large amounts of the drug are swallowed, intoxication may occur, symptoms of which may include nausea, vomiting, abdominal pain and, in rare cases, allergic reactions or respiratory arrest.

Interactions with other drugs

1. Antiseptics and antimicrobials: Concomitant use of hexetidine with other oral antiseptics may result in enhanced antimicrobial action. However, it is not recommended to mix hexetidine with other antiseptics in the same solution without consulting a physician or pharmacist.
2. Local anesthetics: The use of hexetidine concomitantly with oral local anesthetics may reduce their efficacy due to potential interactions between them.
3. Oral medicines: Someoral medicines may contain ingredients that may interact with hexetidine. Your doctor or pharmacist should be consulted before using such medicines with hexetidine.
4. Alcoholic preparations: Hexetidine may contain small amounts of alcohol. When using hexetidine concomitantly with other alcoholic preparations, caution should be exercised to avoid a potential increase in alcoholic effects.