Rhinofluimucil

Rhinofluimucil is a combination drug that is used to treat various upper respiratory tract diseases, especially in the presence of thick mucous or mucopurulent (mucopurulent) secretion. The active ingredients of the drug are acetylcysteine and tuaminoheptane sulfate.

• Acetylcysteine acts as a mucolytic: it liquefies sputum, making it easier to expectorate. Acetylcysteine breaks disulfide bonds of mucopolysaccharide chains and thus breaks mucoprotein complexes of mucus, which makes sputum less viscous.
• Tuaminoheptane sulfate is a sympathomimetic. It narrows blood vessels, reducing swelling of the nasal mucosa and sinuses, which facilitates breathing.

Rhinofluimucil is often prescribed for sinusitis, rhinitis of various origins, including allergic, as well as for other conditions accompanied by the formation of thick mucus in the respiratory tract. The drug is available in the form of a nasal spray, which ensures its local action directly in the area of application.

Like any medicine, Rhinofluimucil has contraindications and may cause side effects such as nasal dryness, burning or redness of the nasal mucosa, and other reactions. Before use, it is important to consult your doctor and carefully study the instructions.

Indications Rhinofluimucil

1. Acute and chronic rhinitis is an inflammation of the nasal mucosa that can be caused by various factors, including infections and allergies. The drug helps to reduce swelling of the mucous membrane and make breathing through the nose easier.
2. Vasomotor rhinitis is a condition characterized by an overreaction of the blood vessels of the nasal mucosa. Rhinofluimucil narrows the blood vessels and reduces symptoms.
3. Allergic rhinitis is a reaction to allergens, which is manifested by runny nose, itching and sneezing. The drug helps to reduce the viscosity of the secretion and facilitate its discharge.
4. Sinusitis (including maxillary sinusitis) is inflammation of one or more sinuses. Acetylcysteine helps to thin the secretion, making it easier to clear and reducing pressure and pain in the sinuses.
5. Acute and chronic bronchitis (as an adjunct to mainstream treatment) is an inflammation of the bronchi that leads to coughing and sputum production. Acetylcysteine promotes easier expectoration of sputum.

Release form

Rhinofluimucil, containing the active substances acetylcysteine (1.0 g) and tuaminoheptane sulfate (0.5 g), is available in the form of nasal spray. The drug is packaged in 10 ml orange glass vials, each vial is equipped with an atomizer.

Pharmacodynamics

Rhinofluimucil is a combination drug that is widely used for the treatment of upper respiratory tract diseases, especially in the presence of thick secretion in the sinuses and nasal cavity. This drug contains two active components: acetylcysteine and tuaminoheptane sulfate, which have different mechanisms of action and complement each other.

Acetylcysteine acts as a mucolytic - it liquefies sputum and promotes its easier discharge by reducing the viscosity of secretion in the sinuses and nasal cavity. This makes breathing easier and helps to clear mucus from the airways.

Tuaminoheptane sulfate acts as a vasoconstrictor. It temporarily constricts the blood vessels in the nasal cavity, which reduces swelling and nasal congestion. This action helps to facilitate breathing through the nose during illness.

The pharmacodynamics of Rinofluimucil combines these two actions, providing an effective remedy for the symptoms associated with nasal congestion, runny nose and other manifestations of upper respiratory tract inflammation.

Pharmacokinetics

Pharmacokinetics of Rhinofluimucil, like any other medical drug, includes the study of the processes to which the active substance undergoes in the human body: its absorption, distribution, metabolism and excretion. Let us consider the pharmacokinetics of two active components of Rinofluimucil - acetylcysteine and tuaminoheptane sulfate.

• Acetylcysteine

Acetylcysteine when administered nasally acts mainly locally and its systemic absorption is minimal. Acetylcysteine applied topically in the nasal cavity liquefies sputum, facilitating its elimination, but there is limited information on its pharmacokinetics in this route of administration. When taken orally, acetylcysteine is rapidly and almost completely absorbed from the gastrointestinal tract, metabolized in the liver to cysteine, as well as to diacetylcysteine and other metabolites. These substances are excreted through the kidneys in the form of sulfate and glucuronide conjugates.

• Tuaminoheptane sulfate

Tuaminoheptane acts mainly locally by constricting blood vessels in the nasal cavity. There is limited information on the pharmacokinetics of tuaminoheptane when administered nasally, as the main effect is achieved through local action. Systemic absorption may be minimal, but specific data on the metabolism and excretion of tuaminoheptane by this route of administration are not well described in the literature.

When applied topically in the nose, as in the case of Rhinofluimucil, the main focus is on the local action of the active ingredients and their systemic absorption is usually low. This means that the active ingredients act predominantly in the region of the sinuses and nasal cavity, minimizing systemic side effects. However, the exact parameters of pharmacokinetics may depend on many factors, including individual characteristics of the patient's body, condition of the nasal mucosa and others.

Dosing and administration

Usually, the recommended treatment regimen includes 2 injections into each nostril 3-4 times a day for up to 7 days. It is important to note that the use of the drug should be coordinated with the attending physician, especially in case of pregnancy.

Use Rhinofluimucil during pregnancy

Information about safety of Rhinofluimucil use during pregnancy is not unambiguously presented in open sources. Some sources indicate the need to avoid its use during this period due to the lack of sufficient data on safety for pregnant women or potential risks.

Contraindications

1. Hypersensitivity to acetylcysteine, tuaminoheptane sulfate or other components of the drug. Use in such cases may cause allergic reactions.
2. Severe forms of hypertension and other serious cardiovascular disease, as tuaminoheptane sulfate may increase blood pressure.
3. Thyrotoxicosis, a condition caused by an excess of thyroid hormones, may be aggravated by the sympathomimetic action of tuaminoheptane.
4. Closed-angle glaucoma - tuaminoheptane can increase intraocular pressure, which is dangerous for people with this condition.
5. Atrophic rhinitis is a chronic disease of the nasal mucosa in which the use of Rhinofluimucil may cause irritation or worsening of the condition.
6. Pheochromocytoma is an adrenal tumor that produces excessive amounts of adrenaline and noradrenaline. Tuaminoheptane can cause crisis high levels of these hormones.
7. Pregnancy and lactation - the safety of using Rinofluimucil during these periods has not been established, so its use is possible only on strict indications and under the supervision of a doctor.
8. Children under 3 years of age - the drug is not recommended for use in children under 3 years of age due to lack of sufficient data on safety and efficacy.

Side effects Rhinofluimucil

The intensity and likelihood of side effects may vary depending on the individual characteristics of the body and compliance with the recommendations for use of the drug.

Side effects of acetylcysteine

• Allergic reactions: may manifest as skin rash, urticaria, pruritus and in rare cases angioedema.
• Local reactions: irritation of the nasal mucosa, sneezing or increased mucus production may occur.

Side effects of tuaminoheptane sulfate

• Systemic effects: increase in blood pressure, tachycardia, restlessness, anxiety, dizziness.
• Local reactions: dryness in the nasal cavity, burning or tingling in the nose after application.

Common side effects

• Respiratory system: sometimes reactions from the respiratory system may occur, such as rapid breathing or a feeling of tightness in the chest.
• Cardiovascular system: rare but possible changes in heart rhythm or increased blood pressure.
• Nervous system: headache, dizziness and insomnia may occur in some patients.

Overdose

Because Rhinofluimucil is applied topically as a nasal spray, cases of systemic overdose are less likely, but the following symptoms may occur with overuse:

1. Increased blood pressure - tuaminoheptane can cause vasoconstriction, resulting in increased blood pressure.
2. Tachycardia - palpitations may result from the sympathomimetic action of tuaminoheptane.
3. Nervousness, rest lessness are possible central effects of overdose associated with sympathomimetic action.
4. Tremor (shaking of the hands) is another possible side effect associated with action on the nervous system.
5. Headache, dizziness are common symptoms that may increase with overdose.
6. Dry mouth, increased intraocular pressure - may result from narrowing of blood vessels.

Interactions with other drugs

1. Vasoconstrictors

Tuaminoheptane, one of the components of Rhinofluimucil, is a vasoconstrictor. The use of Rhinofluimucil together with other vasoconstrictors (e.g. Used for the treatment of runny nose or hypertension) may increase their vasoconstrictive effect, potentially leading to increased blood pressure and other undesirable effects related to the cardiovascular system.

2. Cough suppressants

The use of Rinofluimucil in combination with cough suppressants may make it difficult to expel liquefied mucus from the respiratory tract, since acetylcysteine promotes liquefaction of sputum and facilitates its discharge.

3. Antibiotics

Acetylcysteine can interact with some antibiotics, e.g. Tetracycline, amoxicillin and others, which may reduce their effectiveness when taken concomitantly. It is usually recommended to keep an interval of 2 hours between the intake of acetylcysteine and antibiotics to minimize this interaction.

4. Activated charcoal and other adsorbents

Activated charcoal and other adsorbents may decrease the absorption and efficacy of acetylcysteine when administered concomitantly due to physical binding of acetylcysteine in the gastrointestinal tract (applicable to oral forms of acetylcysteine).

5. Antihypertensive drugs

Administration of Rinofluimucil with antihypertensive drugs requires caution because tuaminoheptane may affect blood pressure, potentially reducing the effectiveness of antihypertensive agents.