Lindinet

Lindinet is the trade name of a combined oral contraceptive drug that contains two active ingredients: gestodene and ethinylestradiol. This drug is used to prevent pregnancy in women.

Oral contraceptives such as Lindinet work by suppressing ovulation, changing the uterine lining and thickening the cervix, which creates a less favorable environment for sperm. They may also reduce the risk of certain diseases such as uterine cancer, ovarian cancer, and ovarian cysts.

It is important to note that "Lindinet" should be taken as prescribed by a doctor and in accordance with the instructions. As with any medication, this drug may have side effects such as nausea, headache, weight changes, appetite changes, and others. Before you start taking Lindinet, you should discuss it with your doctor and consider all possible risks and benefits.

Indications Lindinet

1. Preventing pregnancy: The main indication for the use of Lindinet - is the prevention of pregnancy. Oral contraceptives containing a combination of estrogen and progestin provide a high degree of protection against unwanted pregnancy by suppressing ovulation, altering the uterine lining and thickening the cervix.
2. Menstrual regulation: The drug can also be used to regulate the menstrual cycle. It can help reduce painful menstruation, reduce the amount of bleeding, and make your periods more regular.
3. Treating symptoms of premenstrual syndrome (PMS): "Lindinet may help reduce PMS symptoms such as irritability, nervousness, swelling and breast pain.
4. Prevention of ovarian and endometrial cancer: Use of oral contraceptives, including Lindinet, may reduce the risk of ovarian and endometrial cancer in women.
5. Treatment of acyclic conditions: The drug may be used to treat acyclic conditions such as androgensavis hyperpilosus, acyclic forms of anemia, and acyclic forms of alopecia.

Release form

• Lindinet 20: Each tablet contains 0.02 mg of ethinylestradiol and 0.075 mg of levonorgestrel. This is a lower-dose version that may be preferred by women looking for a contraceptive with less hormone content.
• Lindinet 30: Each tablet contains 0.03 mg of ethinylestradiol and 0.15 mg of levonorgestrel. This is the standard dosage often used as first-line oral contraception.

Pharmacodynamics

1. Estradiol (estrogen):

   • Estradiol is a naturally occurring estrogen that plays a key role in regulating the female reproductive cycle.
   • The mechanism of action of estradiol in "Lindinet" includes stimulation of the growth of the endometrium (the inner layer of the uterus) and its preparation for implantation of a fertilized egg.
   • Estrogens also affect the secretion of cervical mucus, making it thicker and thicker, making it harder for sperm to penetrate the uterus.

2. Levonorgestrel (progestin):

   • Levonorgestrel is a synthetic progestin that has contraceptive effects.
   • The main mechanism of action of levonorgestrel in Lindinet is the suppression of ovulation (the release of the egg from the ovary).
   • Progestins also improve the viscosity of cervical mucus, which makes it harder for sperm to penetrate, and they can affect the motility of the fallopian tubes, which also reduces the risk of fertilization.

3. Other effects:

   • The combination of estrogen and progestin in Lindinet may also have favorable effects on bone tissue, the cardiovascular system, and blood lipid levels.

Pharmacokinetics

1. Absorption: After oral administration, the active ingredients of Lindinet are absorbed from the gastrointestinal tract.
2. Distribution: Estradiol and levonorgestrel are rapidly distributed in tissues and organs of the body, including the liver, kidneys, fat cells, and brain.
3. Metabolism: Estrogens and progestins are metabolized in the liver. Estrogens may be metabolized to conjugated metabolites and excreted with urine and feces. Levonorgestrel is also metabolized in the liver to form various metabolites.
4. Excretion: Estrogen and progestin metabolites are excreted with urine and feces.
5. Half-life: The half-life of estrogens and progestins can vary, but is usually several hours.
6. Kinetics in special patient groups: Pharmacokinetics may be altered in patients with hepatic or renal dysfunction.

Dosing and administration

The dosage and method of use may vary slightly depending on the individual patient and doctor's recommendations, but usually the following are the general instructions for the use of "Lindinet":

1. Beginning of the course:

   • The first pill of "Lindinet" should be taken on the first day of menstruation.

2. Regular admission:

   • Take one Lindinet tablet daily at the same time, preferably in the evening or at night.
   • Keep a strict daily schedule so that you do not skip taking your pills, as this can impair the effectiveness of contraception.

3. Course Duration:

   • Take Lindineta tablets for 21 consecutive days, followed by a break of 7 days.
   • During the 7-day break, menstruation usually occurs.

4. Course Repetition:

   • After a 7-day break, start the next course, starting with a new blister of pills, even if menstruation continues.

5. Continuous application:

   • In case you want to continue contraception without breaks between courses, you should start a new blister of "Lindinet" immediately after finishing the old one, without a 7-day break.
   • However, a one week break is recommended on a regular basis (approximately every 3 months) to renew the endometrium and reduce the risk of unwanted effects.

It is important to strictly follow the instructions for use provided by your doctor or stated in the instructions for the drug.

Use Lindinet during pregnancy

The use of Lindinet during pregnancy is not recommended. This drug is intended to control reproductive function and may adversely affect fetal development when used during pregnancy.

If a woman becomes pregnant while taking the drug, it is imperative that she discontinue use and immediately contact her doctor for counseling. This is especially important because stopping Lindinet during pregnancy can help prevent potential health risks to the baby.

Contraindications

1. Thrombosis and thromboembolic complications: Lindinet is contraindicated in patients with a history of thrombosis (formation of a blood clot in a blood vessel) or thromboembolic complications (including deep venous thrombosis and pulmonary embolism), as it may increase the risk of these.
2. Cerebrovascular disease: The drug is contraindicated in patients with a history of stroke or other cerebrovascular disease, as it may increase the risk of recurrent stroke or other serious complications.
3. Cardiovascular disease: Lindinet use may be contraindicated in patients with serious cardiovascular disease such as coronary heart disease or heart failure, especially in the presence of concomitant risk factors such as smoking.
4. Liver diseases: The drug is contraindicated in patients with severe hepatic dysfunction or with a history of liver disease, as it may worsen liver function and lead to the development of complications.
5. Kidney disease: Lindinet should be used with caution in patients with severe renal dysfunction or a history of kidney disease, as it may increase the risk of complications.
6. Pregnancy: The drug is contraindicated during pregnancy and should not be used in this case.
7. Breastfeeding: The use of Lindinet is not recommended during breastfeeding due to the risk of transmission of active ingredients through breast milk.
8. Hypersensitivity to the drug components: Patients with known hypersensitivity to estradiol, levonorgestrel or other components of the drug should also avoid using the drug.

Side effects Lindinet

1. Headaches and migraines.
2. GI disorders: nausea, vomiting, diarrhea or constipation.
3. Water edema, especially in the legs and arms.
4. Breast pain.
5. Weight changes: both weight gain and weight loss.
6. Mood and emotional changes: irritability, depression, changes in emotional state.
7. Decreased libido.
8. Changes in the menstrual cycle, including the intervals between periods.
9. Increased blood pressure.
10. Increased nipple size and sensitivity.
11. Rarely, allergic reactions may occur.

Overdose

An overdose of Lindinet, like other combined oral contraceptives, can cause a variety of unwanted effects, including nausea, vomiting, vaginal bleeding, headache, fatigue, and other symptoms associated with hormone oversaturation.

In case of suspected overdose, medical attention should be sought. Treatment of overdose may include symptomatic therapy, such as gastric lavage, administration of activated charcoal or other means to reduce absorption of the drug, as well as supportive measures to eliminate unwanted symptoms.

Interactions with other drugs

1. Drugs affecting the liver: Lindinet is metabolized in the liver, so drugs that affect liver function may alter its metabolism. For example, liver enzyme inducers such as rifampicin or phenytoin may decrease the concentration of estrogens and progestins in the blood, which may reduce the effectiveness of contraception.
2. Drugs that increase the risk of thrombosis: The drug contains estrogens, which may increase the risk of thrombosis. If taken concomitantly with anticoagulants or antiaggregants, the risk of bleeding or thrombosis may increase.
3. Drugs that reduce contraceptive efficacy: Some drugs such as antibiotics (e.g., ampicillin, tetracycline) may reduce contraceptive efficacy by disrupting gut microflora, which affects absorption of contraceptives.
4. Drugs that affect symptoms of premenstrual syndrome (PMS): Drugs used to treat PMS symptoms, such as diuretics or antidepressants, may interact with Lindinet, altering its effectiveness or causing additional side effects.
5. Drugs affecting gastric acidity: Drugs such as proton inhibitors (e.g. Omeprazole) may reduce the absorption of Lindinet by altering gastric acidity.

Storage conditions

1. Dry place: The drug should be stored in a dry place to avoid exposure to moisture, which may adversely affect the stability and efficacy of the drug.
2. Protection from light: The drug should be stored in a package protected from direct sunlight or bright light to avoid degradation of active ingredients by light.
3. Room temperature: Lindinet is usually stored at room temperature, which is usually between 15 and 25 degrees Celsius. This helps to keep the drug stable.
4. Away from children: The drug should be kept out of the reach of children to avoid accidental use.
5. Not in the bathroom: It is not recommended to store the preparation in the bathroom or other places with high humidity, as this may also adversely affect the stability of the preparation.
6. Avoid places with strong odors: Keep the preparation away from places with strong odors, as they may have a negative effect on the quality and stability of the preparation.