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Sincumar
Last reviewed: 07.06.2024
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Sincumar is an indirect anticoagulant, a vitamin K antagonist. It disrupts the synthesis of prothrombin (clotting factor II), proconvertin (clotting factor VII), factors IX and X.
Indications Sinkumara
Thrombosis, thrombophlebitis, thromboembolic complications of myocardial infarction, embolic stroke, thromboembolism of various organs.
In surgical practice - to prevent thromboembolic complications in the postoperative period.
Release form
10 pcs. - contoured cell packs (5) - carton packs.
Pharmacodynamics
The maximum effect is observed 24-48 h after oral administration. After withdrawal of acenocoumarol, the initial prothrombin content is restored on the 2nd-4th day.
Pharmacokinetics
When administered orally, acenocoumarol has a high degree of absorption, Cmax is reached in 1-8 h, binding to plasma proteins is 99%. Cumulates with repeated administration.
Penetrates through the placental barrier, is excreted with breast milk.
Dosing and administration
Set individually, depending on blood coagulation indications. On the 1st day of treatment the dose is 8-16 mg/day, on the 2nd day - 4-12 mg/day; on the 3rd day - 6 mg. Maintenance dose (after prothrombin index value decreases to 50%) - 1-6 mg. Frequency of administration - 1 time/day at the same time.
Use Sinkumara during pregnancy
Contraindicated use in pregnancy and during breastfeeding.
Contraindications
Hemorrhagic diathesis, hypocoagulation, hypoprothrombinemia (less than 70%), renal failure, marked liver dysfunction, arterial hypertension, pericarditis, erosive and ulcerative lesions of the GI tract, malignant neoplasms, diabetic retinopathy, physical exhaustion, hypovitaminosis K and C, pregnancy, postpartum eclampsia, preeclampsia, breastfeeding, hypersensitivity to acenocoumarol.
Side effects Sinkumara
Blood coagulation system: bleeding, hemorrhages on the skin and mucous membranes (by degree of decreasing probability): hematuria, bleeding from the gums, petechiae, post-traumatic hematoma, melena, metrorrhagia, hemarthrosis, hemorrhagic stroke; withdrawal syndrome - increased risk of thrombosis.
Digestive system: nausea, diarrhea.
Dermatologic reactions: alopecia, skin necrosis.
Allergic reactions: fever, skin rashes.
Other: headache.
Special instructions
During treatment, it is necessary to carefully monitor the general condition of the patient and changes in the coagulation system of the blood.
If bleeding or bleeding occurs against the background of therapy, acenocoumarol should be canceled.
Use in liver function disorders
Contraindicated use in severe liver dysfunction.
Use in renal dysfunction
Contraindicated use in renal insufficiency.
Use in elderly patients
In elderly and elderly patients, especially those with significant atherosclerosis, therapy should be monitored more frequently and, if possible, the dose of acenocoumarol should be reduced.
Attention!
To simplify the perception of information, this instruction for use of the drug " Sincumar" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.