Organometal

Orgametril demonstrates progestogenic activity. The medicine is an artificial progestogen that must be taken orally.

The active drug element has medicinal properties that are also found in natural progesterone. During therapy with the use of this medication, an intensive progestogenic effect on the endometrium develops. With its continuous intake, there is a depression of menstruation and ovulation, because of which the drug is used if necessary in the development of a strong progestogenic effect.

[1], [2], [3]

Indications Organometals

It is applied in case of such violations:

• dysfunctional bleeding from the uterus;
• oligomenorrhea, amenorrhea or dysmenorrhea;
• endometriosis or endometrial cancer;
• SP;
• a benign neoplasm in the breast;
• delay in normal menstruation;
• HRT with the use of estrogen (in combination therapy).

Release form

The release of drugs is sold in tablets - 30 pieces inside a cell bundle; In the box - 1 such a pack.

[4], [5], [6], [7]

Pharmacokinetics

Linesteron is absorbed at high speed inside the body, transforming into active norethisterone. Exchange processes are implemented inside the liver. Plasma Cmax values of norethisterone are recorded after 2-4 hours from the moment of use of the drug.

The excretion of the drug is implemented through the intestines and kidneys.

[8], [9], [10],

Dosing and administration

The drug is administered orally, the tablets are washed down with plain water. If the next portion was missed, it is immediately taken (but only in cases when the delay in use is less than 24 hours).

It is necessary to take into account that the first day of the cycle is the beginning of menstruation.

In the case of the development of polymenorrhea, 5 mg of a substance is applied per day (1 per tablet) - within the 14–25th day of the cycle, during menstruation.

In case of metrorrhagia and menorrhagia, it is necessary to consume 2 tablets a day for 10 days. Often the bleeding stops after a few days. The treatment course is repeated for 3 consecutive menstrual cycles per serving, which is taken on the 14-25th days. In the absence of a result from therapy, additional diagnostics are performed and a different treatment regimen is selected.

Prescribe medication can only the attending doctor who selects a therapeutic regimen and portion sizes. Constantly performed diagnostics, which should confirm the effectiveness of therapy. Using Orgametril without a prescription is prohibited.

[18], [19], [20], [21]

Use Organometals during pregnancy

It is forbidden to use in case of pregnancy.

Contraindications

Among the contraindications:

• severe disorders and pathologies associated with hepatic activity;
• having an unknown nature of bleeding from the vagina;
• herpes or severe itching associated with therapy, in which steroid substances are used.

[11], [12], [13], [14], [15], [16], [17]

Side effects Organometals

The use of the medication can cause the appearance of some side effects, including: weight gain, nausea, as well as the appearance of spotting and heavy bleeding.

Occasionally, there is the development of depression, headaches, migraines, nervousness, pain in the sternum, dizziness and jaundice, and in addition to this change in hepatic activity. In addition, a decrease in glucose tolerance, the development of epidermal rash and itching, chloasma, acne and hirsutism were recorded. After completion of therapy, amenorrhea and edema may occur.

Overdose

When poisoning, vomiting appears with nausea.

Symptoms are performed when abnormalities occur.

[22], [23], [24], [25], [26], [27]

Interactions with other drugs

The combination of the drug with barbiturates, activated carbon, rifampicin, carbamazepine, and in addition with derivatives of hydantoin, laxatives and aminoglutetimidom leads to a significant weakening of its therapeutic effect.

At the same time, Orgametril itself can enhance the drug, drug or toxicological effects of theophylline, cyclosporine, as well as β-blockers and troleandomycin.

Introduction together with macrolides sometimes causes liver intoxication.

The drug may impair the therapeutic activity of insulin.

[28], [29], [30], [31], [32], [33]

Storage conditions

Orgametril is required to keep in a closed from children, penetration of moisture and sunlight.

[34], [35], [36]

Shelf life

Orgametril can be applied for a 5-year period from the moment a pharmaceutical product is sold.

Analogs

Analogues of the medication are Exluton drugs with Linestrenol.

[37], [38], [39], [40], [41],

Reviews

Orgametril generally receives positive reviews in medical forums. Patients note that the medication not only has a powerful therapeutic effect, but in addition does not lead to the appearance of negative symptoms. Occasionally, women who use the medication have an increase in weight, but this does not happen with the right choice of therapy.

[42], [43], [44], [45], [46], [47],